GEO DataSets

(Submitter supplied) Colorectal cancer cell line aCGH, in reference to normal genomic DNA

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platforms:

GPL5477 GPL2873

12 Samples

Download data: TXT

(Submitter supplied) Oligonucleotide aCGH profiles from 37 neuroblastoma tumor samples were generated using 44K or 105K microarrays.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platforms:

GPL4093 GPL2873 GPL2879

37 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Genome variation profiling by array; Expression profiling by array

6 related Platforms

881 Samples

Download data: TXT

(Submitter supplied) Oligonucleotide aCGH profiles from 209 neuroblastoma tumor samples were generated using 44K, 105K or 1M microarrays. The 209th sample is represented by Sample GSM634116.

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platforms:

GPL16865 GPL8355 GPL2873

76 Samples

Download data: TXT

(Submitter supplied) Less than 30% of children with high-risk (HR) metastatic neuroblastoma (NB) show a long survival (Pearson 2000). In order to identify novel molecular prognostic markers useful to better predict patients’ relapse risk estimation, we performed genome- and/or transcriptome-wide analyses of 129 stage 4 HR-NBs. This is the largest study for this NB subtype. Children older than 1 year of age at diagnosis were categorized as “short-survivors” (dead of disease within 5 years from diagnosis) and “long-survivors” (alive with an overall survival time > 5 years). more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platforms:

GPL2873 GPL5477

35 Samples

Download data: TXT

(Submitter supplied) Neuroblastoma (NB) is an aggressive tumor that affects both infants and children. The disease outcome is greatly influenced by age of patient, stage, chromosome copy number aberrations (CNAs) and gene expression abnormalities. We analyzed, by microarray technology, genome and transcriptome of 3 groups of tumors of patients with metastatic disease: G1, stage 4S and MYCN single copy; G2, stage 4 younger than 18 months of age, MYCN single copy with no disease progression and G3, stage 4, older than 19 months, with unfavorable outcome. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

4 related Platforms

133 Samples

Download data: TXT

(Submitter supplied) Background: Castration-resistant prostate cancer (CRPC) represents a therapeutic challenge for current medications. Methods: In order to explore the molecular mechanisms involved in CRPC progression and to identify new therapeutic targets, we analyzed a unique sample set of 11 castration-resistant prostate cancers and 7 advanced tumors by array-CGH and gene expression microarrays. The genome-wide DNA and RNA data were integrated to identify genes whose overexpression was driven by their amplification. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array

4 related Platforms

47 Samples

Download data: CEL, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:

GPL570 GPL4091 GPL2873

64 Samples

Download data: CEL, TXT

(Submitter supplied) In multiple myeloma (MM), endothelial progenitor cells (EPCs) regulate tumor angiogenesis and disease progression. EPCs from 16 newly diagnosed patients with advanced MM were examined for genomic instability by aCGH to assess chromosomal gains and losses. Data were compared to aCGH results from corresponding CD138+ tumor plasma cells from these patients.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platforms:

GPL4091 GPL2873

32 Samples

Download data: TXT, XLS

(Submitter supplied) Background: Genomic instability is a hallmark of cancer and is frequently reflected in the DNA copy number profile and the expression profile of genes. Methodology is needed to compare array-CGH data and microarray expression data in order to unveil effects of DNA copy number alterations of a gene on the expression of the gene itself (in-cis effects) and on other genes (in-trans effects). Results: We present a method for detection of gene dosage effects on gene expression that first searches for genome-wide in-cis associations between copy number and expression, and then investigates in-trans effects of these genes. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL2873

20 Samples

Download data: TXT

(Submitter supplied) We performed array CGH in high-risk neuroblastoma tumors in order to compare genome aberrations with expression of small non-coding RNAs.

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platforms:

GPL2873 GPL5477

33 Samples

Download data: TXT

(Submitter supplied) Tumors often harbor several genetic aberrations at both RNA and DNA level. Integration of expression data with copy number changes represents a powerful strategy to investigate genes involved in tumorigenesis. Here we describe a fluorescent array-based Comparative Genomic Hybridization protocol to be used on a commercial microarray platform optimized to detect cancer-related gene expression. This method will be valuable to use a single low-density array platform monitoring gene expression and copy number assessment in parallel. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array; Genome variation profiling by genome tiling array

Platforms:

GPL6745 GPL2873

4 Samples

Download data: TXT

(Submitter supplied) Background There is much discussion in the cancer drug development community about how to incorporate molecular tools into early-stage clinical trials to assess target modulation, measure anti-tumor activity, and enrich the clinical trial population for patients who are more likely to benefit. Small, molecularly focused clinical studies offer the promise of the early definition of optimal biologic dose and patient population. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL2873

16 Samples

Download data: TIFF, TXT

(Submitter supplied) Isolated deletions of the long arm of chromosome 5 (del(5q)) are observed in 10% of myelodysplastic syndromes (MDS) and are associated with a more favorable prognosis, although the clinical course varies considerably. If one or more additional chromosomal aberration/s are present this correlates with a significant shorter overall survival. To assess the frequency of hidden abnormalities in cases with an isolated cytogenetic del(5q), we have performed a genome wide high resolution 44K 60mer oligonucleotide array CGH study using DNA from bone marrow cells of 12 MDS and one AML patient. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platforms:

GPL2873 GPL2879

13 Samples

Download data: TXT

(Submitter supplied) CGH analysis was conducted for AML blasts with Agilent HG44A arrays. Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL2873

32 Samples

Download data: TXT