GEO DataSets

(Submitter supplied) Background and aims: The intrahepatic processes associated with chronic hepatitis B (CHB), especially in the context of HDV and HIV co-infection, require a better understanding. Spatial transcriptomics can provide new insights into the complex intrahepatic biological processes, guiding new personalized treatments. Our aim is to evaluate this method to characterize the hepatic transcriptional landscape, cellular composition and biological pathways in liver biopsy samples from patients infected with HBV and HDV or HIV co-infection. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL30991

37 Samples

Download data: DCC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL24676 GPL30991 GPL24247

103 Samples

Download data: DCC, H5, TAR

(Submitter supplied) The olfactory epithelium relies on active neuron regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare, aggressive tumor of unclear origins. Here, we establish a new, highly-penetrant, genetically-engineered mouse model of ONB with alterations in Rb1/Trp53/Myc that exhibit a NEUROD1+ immature neuronal state. ASCL1 loss leads to emergence of non-neuronal histopathologies, including a POU2F3+ microvillar-like state. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL30991

96 Samples

Download data: DCC

(Submitter supplied) Idiopathic Pulmonary Arterial Hypertension (IPAH) is a severe human disease, characterized by extensive pulmonary vascular remodeling due to plexiform and obliterative lesions, media hypertrophy, and alterations of adventitia. The objective of the study was to test the hypothesis that microscopic IPAH vascular lesions express unique molecular profiles, which collectively are different from control pulmonary arteries. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL30991

220 Samples

Download data: DCC, TXT

(Submitter supplied) Genomic and epigenomic studies support that adenocarcinomas of the gallbladder develop according to a metaplasia-biliary intraepithelial neoplasia (BilIN)-adenocarcinoma histogenic sequence, in which metaplasia and BilIN are non-cancerous lesions of the epithelium. Moreover, recent genomic data suggest that adenocarcinoma can develop in a BilIN-dependent or -independent way, pointing toward patient-specific tumourigenic processes. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL30991

56 Samples

Download data: XLSX

(Submitter supplied) Human RNA for Illumina Systems. RNA Probe set that targets 18,000+ transcripts for human protein-coding genes plus ERCC negative controls to profile the whole transcriptome. Excludes uninformative high expressing targets such as ribosomal subunits. Includes RNA probes designed for Illumina NGS readout with the Seq Code library prep. *** IMPORTANT NOTE ***: For NanoString GeoMx Digital Spatial Profiling studies with raw data in FASTQ format, please submit your study using GEO's high throughput sequence data submission instructions at: https://www.ncbi.nlm.nih.gov/geo/info/seq.html Protocol: See NanoString web site.

Organism:

Homo sapiens

5 Series

409 Samples

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