GSE124754[Accession] - GEO DataSets

Select item 2001247541.

mTORC1 feedback to AKT modulates MiT/TFE-driven lysosomal biogenesis and EGFR degradation

(Submitter supplied) MiT/TFE transcriptional activity controls lysosomal biogenesis and is negatively regulated by the nutrient sensor mTORC1. Some tumors bypass this regulatory circuit via genetic alterations that drive MiT/TFE expression and activity; however, the mechanisms by which cells with intact or constitutive mTORC1 signaling maintain lysosomal catabolism remain to be elucidated. Using the murine epidermis as a model system, we find that epidermal Tsc1 deletion results in a wavy hair phenotype due to increased EGFR degradation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL20775
6 Samples

Download data: CEL

Series

Accession:: GSE124754

ID:: 200124754

Analyze with GEO2R

Select item 1000207752.

[MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CSV version]

(Submitter supplied) Annotation was derived from the Affymetrix annotation file MTA-1_0.na35.mm10.transcript.csv: #%create_date=Wed Apr 1 16:56:09 2015 PDT #%chip_type=MTA-1_0 #%lib_set_name=MTA-1_0 #%lib_set_version=r1 #%genome-species=Mus musculus #%genome-version=mm10 #%genome-version-ucsc=mm10 #%genome-version-ncbi=38 #%genome-version-create_date=2011-12-00 #%genome-lifted-method=psl-map.pl #%genome-lifted_from-species=Mus musculus #%genome-lifted_from-version-ucsc=mm10 #%genome-lifted_from-version-ncbi=38 #%netaffx-annotation-date=2014-10-31 #%netaffx-annotation-netaffx-build=35 Protocol: See manufacturers website