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Items: 9

1.

IPSC-derived neuronal cultures expressing the Alzheimer's disease associated rare TREM2 R47H variant enables the construction of an Aβ-induced gene regulatory network

(Submitter supplied) Recently, genes associated with immune response and inflammation have been identified as genetic risk factors for late-onset Alzheimer's disease (LOAD). One of them is the rare p.Arg47His (R47H) variant within triggering receptor expressed on myeloid cells 2 (TREM2), which has been shown to increase the risk for developing AD 2-3-fold. Here, we report the generation and characterization of a model of LOAD using lymphoblast-derived iPSCs from patients harbouring the R47H mutation in TREM2 (AD TREM2 iPSCs), as well as from control individuals without dementia (CON iPSCs). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16043
7 Samples
Download data: CEL
Series
Accession:
GSE143951
ID:
200143951

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

GeneChip® PrimeView™ Human Gene Expression Array (with External spike-in RNAs)

(Submitter supplied) See details from Affymetrix. This is a commercially available chip.
Organism:
Homo sapiens
89 Series
6761 Samples
Download data: CDF, TXT
Platform
Accession:
GPL16043
ID:
100016043

3.

TREM2_Abeta_1

Organism:
Homo sapiens
Source name:
iPSC-derived neuronal cultures
Platform:
GPL16043
Series:
GSE143951
Download data: CEL
Sample
Accession:
GSM4277196
ID:
304277196

4.

TREM2_2

Organism:
Homo sapiens
Source name:
iPSC-derived neuronal cultures
Platform:
GPL16043
Series:
GSE143951
Download data: CEL
Sample
Accession:
GSM4277195
ID:
304277195

5.

TREM2_1

Organism:
Homo sapiens
Source name:
iPSC-derived neuronal cultures
Platform:
GPL16043
Series:
GSE143951
Download data: CEL
Sample
Accession:
GSM4277194
ID:
304277194

6.

healthy_Abeta_1

Organism:
Homo sapiens
Source name:
iPSC-derived neuronal cultures
Platform:
GPL16043
Series:
GSE143951
Download data: CEL
Sample
Accession:
GSM4277193
ID:
304277193

7.

healthy_2

Organism:
Homo sapiens
Source name:
iPSC-derived neuronal cultures
Platform:
GPL16043
Series:
GSE143951
Download data: CEL
Sample
Accession:
GSM4277192
ID:
304277192

8.

TREM2_Abeta_2

Organism:
Homo sapiens
Source name:
iPSC-derived neuronal cultures
Platform:
GPL16043
Series:
GSE143951
Download data: CEL
Sample
Accession:
GSM4277191
ID:
304277191

9.

healthy_1

Organism:
Homo sapiens
Source name:
iPSC-derived neuronal cultures
Platform:
GPL16043
Series:
GSE143951
Download data: CEL
Sample
Accession:
GSM4277190
ID:
304277190

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