GEO DataSets

(Submitter supplied) The transcription factor c-JUN and its upstream kinase JNK1 have been implicated in BCR-ABL induced leukemogenesis. JNK1 has been shown to regulate BCL2 expression thereby altering leukemogenesis, but the impact of c-JUN remained unclear. In this study we show that JNK1 and c-JUN promote leukemogenesis via separate pathways, since lack of c-JUN impairs proliferation of p185BCR-ABL transformed cells without affecting viability. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4205

Platform:

GPL6246

8 Samples

Download data: CEL

Analysis of B lymphoid cells depleted of activating protein 1 (AP-1) transcription factor c-JUN. c-JUN is involved in BCR-ABL oncogene-induced transformation and leukemogenesis. Results provide insight into the molecular mechanisms underlying c-JUN modulation of leukemogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE27028

8 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Mus musculus

143 DataSets

2504 Series

28 Related Platforms

30419 Samples

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