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Items: 10

1.

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback compensation in PTEN-mutant prostate cancer progression

(Submitter supplied) Hyper-activation of the PI 3-Kinase/ AKT pathway is a driving force of many cancers. Here we identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor suppressor. We show that Phlpp1-loss causes neoplasia and, upon partial Pten-loss, carcinoma in mouse prostate. This genetic setting initially triggers a growth suppressive response via p53 and the Phlpp2 ortholog, and reveals spontaneous Trp53 inactivation as a condition for full-blown disease. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE30987
ID:
200030987

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site
Organism:
Mus musculus
143 DataSets
2504 Series
28 Related Platforms
30419 Samples
Download data
Platform
Accession:
GPL6246
ID:
100006246

3.

Pten/Phlpp double mutant, 6 month timepoint, replicate 1

Organism:
Mus musculus
Source name:
Pten/Phlpp
Platform:
GPL6246
Series:
GSE30987
Download data: CEL
Sample
Accession:
GSM780872
ID:
300780872

4.

Pten/Phlpp double mutant, 4 month timepoint, replicate 1

Organism:
Mus musculus
Source name:
Pten/Phlpp
Platform:
GPL6246
Series:
GSE30987
Download data: CEL
Sample
Accession:
GSM780871
ID:
300780871

5.

Wild type, 6 month timepoint, replicate 3

Organism:
Mus musculus
Source name:
WT
Platform:
GPL6246
Series:
GSE30987
Download data: CEL
Sample
Accession:
GSM780870
ID:
300780870

6.

Wild type, 6 month timepoint, replicate 2

Organism:
Mus musculus
Source name:
WT
Platform:
GPL6246
Series:
GSE30987
Download data: CEL
Sample
Accession:
GSM780869
ID:
300780869

7.

Wild type, 6 month timepoint, replicate 1

Organism:
Mus musculus
Source name:
WT
Platform:
GPL6246
Series:
GSE30987
Download data: CEL
Sample
Accession:
GSM780868
ID:
300780868

8.

Wild type, 4 month timepoint, replicate 3

Organism:
Mus musculus
Source name:
WT
Platform:
GPL6246
Series:
GSE30987
Download data: CEL
Sample
Accession:
GSM780867
ID:
300780867

9.

Wild type, 4 month timepoint, replicate 2

Organism:
Mus musculus
Source name:
WT
Platform:
GPL6246
Series:
GSE30987
Download data: CEL
Sample
Accession:
GSM780866
ID:
300780866

10.

Wild type, 4 month timepoint, replicate 1

Organism:
Mus musculus
Source name:
WT
Platform:
GPL6246
Series:
GSE30987
Download data: CEL
Sample
Accession:
GSM780865
ID:
300780865

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db=gds|term=GSE30987[Accession]|query=1|qty=2|blobid=MCID_6748cab843705129cf48d2fc|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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