GEO DataSets

(Submitter supplied) A major mechanism of azole resistance in Candida albicans is the over-expression of the genes encoding the ABC transporters Cdr1p and Cdr2p. Constitutive over-expression of these efflux pumps is due to mutations in the gene encoding Tac1p, resulting in hyperactivity of this zinc cluster transcription factor. In order to identify the transcriptional targets of Tac1p, we examined four matched sets of clinical isolates representing the development of CDR1- and CDR2-mediated azole resistance, using gene expression profiling analysis. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL5723

27 Samples

Download data: CEL, CHP

(Submitter supplied) The nucleotide sequences corresponding to 6165 open reading frames (ORFs) for C. albicans were downloaded from the Galar Fungail European Consortium (Assembly 19, http://www.pasteur.fr/Galar_Fungail/CandidaDB/). Following the Affymetrix Design Guide, we set out to design two separate probe sets for each ORF, each consisting of 13 perfect matches and 13 mismatches overlapping 25 bp oligonucleotides, to the 3’ 600 bp region. more...

Organism:

Candida albicans

3 Series

43 Samples

Download data: CDF