GEO DataSets

(Submitter supplied) Dendritic cells (DCs) are crucial for sensing pathogens and triggering immune response. GM-CSF myeloid dendritic cells (GM-DCs) secrete several cytokines including IL-2 upon activation by pathogen associated molecular pattern (PAMP) ligands. DC IL-2 has been shown to be important for innate and adaptive immune responses, however its importance in DC physiology has never been demonstrated. This is due to ambiguity in expression of the CD122 subunit of the IL-2 trimeric receptor complex crucial for signaling. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5665

Platform:

GPL6246

12 Samples

Download data: CEL

Analysis of GM-CSF myeloid dendritic cells (GM-DCs) isolated from interleukin-2 (IL-2) knockouts and activated with curdlan, a pathogen-associated molecular pattern (PAMP). GM-DCs secrete cytokines such as IL-2, upon PAMP activation. Results provide insight into role of IL-2 signaling in DCs.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE58120

12 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Mus musculus

143 DataSets

2504 Series

28 Related Platforms

30419 Samples

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