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Items: 4

1.

DNA methylation patterns separate senescence from malignant transformation potential in human cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Methylation profiling by array
Platforms:
GPL10332 GPL13534
39 Samples
Download data: IDAT, TXT
Series
Accession:
GSE91071
ID:
200091071
2.

DNA methylation patterns separate senescence from malignant transformation potential in human cells [methylation]

(Submitter supplied) Replicative senescent cells reportedly share similar DNA methylation changes with cancer cells, which are purported to facilitate tumorigenesis in cells bypassing senescence. However, we now report biologically critical and distinct patterns of DNA methylation evolution between replicative and oncogene-induced senescence and transformation in a classic human cell transformation model. While overall DNA methylation losses and gains occur in both replicative senescent and transformed cells, the patterns evolve more programmatically for the former and stochastically for the latter. more...
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL13534
31 Samples
Download data: IDAT, TXT
Series
Accession:
GSE91069
ID:
200091069
3.

Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

(Submitter supplied) 1 difference between HumanMethylation450_15017482_v.1.1.bpm and HumanMethylation450_15017482_v.1.2.bpm: 1.1: 41636384,NEGATIVE,-99,Negative 604 1.2: 41636384,RESTORATION,Green,Restore Protocol: See manufacturer's website
Organism:
Homo sapiens
1686 Series
1 Related Platform
119315 Samples
Download data: BPM, CSV, TXT, XLSX
Platform
Accession:
GPL13534
ID:
100013534
4.

genomic DNA from Near_Sen_HRAS

Organism:
Homo sapiens
Source name:
hTERT, SV40 and H-rasV12 Infected Near Senescent Cells
Platform:
GPL13534
Series:
GSE91069 GSE91071
Download data: IDAT
Sample
Accession:
GSM2420517
ID:
302420517
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