GSM2862247[Accession] - GEO DataSets

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Items: 3

Select item 2001071781.

Effects of oxidative stress on mitotic recombination and genomic stability in yeast after 20 passages

(Submitter supplied) Oxidative stress is a common factor threatening genomic stability in almost all aerobic organisms. Using a yeast screening system, we measured the frequency of mitotic recombination was greatly elevated after H2O2 treatment. H2O2 was able to break chromatid directly in G1 synchronized cells and homologous recombination was induced to repair DNA double stand breaks at S/G2 phase. By whole genome SNP microarray and sequencing, the patterns of H2O2 induced loss of heterozygosity (LOH; gene conversion and crossover), chromosomal rearrangement, and aneuploidy changes were revealed. more...

Organism:: Saccharomyces cerevisiae

Type:: Genome variation profiling by SNP array

Platform:: GPL20144
30 Samples

Download data: GPR

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Accession:: GSE107178

ID:: 200107178

PubMed Full text in PMC Similar studies

Select item 1000201442.

Agilent-027438 Yeast S-Y SNP v1 [Probe Name Version]

(Submitter supplied) Whole genome SNPs between S288c and YJM789. Both Watson and Crick strands represented as well as both probes specific to both strains. In the labels of the oligonucleotides 'SF', 'SR', 'YF' and 'YR' refer to the orientation and origin of the sequences used for the oligonucleotides on the microarrays. 'S' and 'Y' indicate whether the oligonucleotide contains sequences identical to the reference S288c genome (closely related to W303-1A) or the YJM789 genome, respectively. more...