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Items: 3

1.

Effects of the novel PI3K δ/γ inhibitor RP6530 on global gene expression in Hodgkin Lymphoma cell lines.

(Submitter supplied) Tumor-associated macrophages (TAMs) are involved in the pathogenesis of Hodgkin lymphoma (HL) and correlate with negative prognosis. The phosphatidylinositol 3-kinase (PI3K) mediates tumor and endothelial cell survival, and macrophage activation. As PI3Kδ and PI3Kγ are constitutively activated in HL, we describe RP6530, a novel PI3Kδ/γ inhibitor, in clinical development for HL and NHL. RP6530 exhibits anti-proliferative and cytotoxic activity both in vitro in HL cell lines and in vivo in HL xenograft mouse models. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
24 Samples
Download data: BW
Series
Accession:
GSE105439
ID:
200105439

PubMed Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12926 Series
348519 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

3.

L540_C2_100nM_6h

Organism:
Homo sapiens
Source name:
L-540 cell line
Platform:
GPL18573
Series:
GSE105439
Download data: BW
Sample
Accession:
GSM3307266
ID:
303307266

SRA Run Selector

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db=gds|term=GSM3307266[Accession]|query=1|qty=2|blobid=MCID_679eaafd55a6950b4d7df228|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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