GSM4133822[Accession] - GEO DataSets

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Items: 4

Select item 2001391991.

Shape of promoter antisense RNAs regulates ligand-induced transcription activation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; synthetic construct

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL16791 GPL17769
101 Samples

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Series

Accession:: GSE139199

ID:: 200139199

PubMed Full text in PMC Similar studies

Select item 2001391962.

ChIRC-seq Reveals Promoter Antisense RNAs and HP1α as Key Regulators of Promoter Pause Release and of Enhancer : Architectural RNA Interactions [ChIP-Seq]

(Submitter supplied) Demonstration of a massive lncRNA RNA transcriptional program in the mammalian genome has engendered lively discussions about their biological roles, particularly the promoter antisense (PAS) transcripts of coding gene transcription units and abundant species localized to specific subnuclear structures with phase separation properties. Here, we report development of an alternative assay to quantitatively detect RNA distribution in the genome, referred to as ChIRC-seq (Chromatin Isolation by RNA-Cas13a Complex Capture by Cas13a), which has revealed that promoter antisense RNAs (PAS-RNAs) serve as a key gatekeeper of a broad transcriptional pause release program, based on decommissioning the 7SK snRNA-dependent inhibitory P-TEFb complex. more...