GSM4336127[Accession] - GEO DataSets

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Items: 4

Select item 2001458781.

p300 suppresses the transition of myelodysplastic syndrome to acute myeloid leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

4 related Platforms
74 Samples

Download data: BIGWIG, BW, NARROWPEAK

Series

Accession:: GSE145878

ID:: 200145878

PubMed Full text in PMC Similar studies

Select item 2001458192.

p300 suppresses the transition of myelodysplastic syndrome to acute myeloid leukemia [RNA-Seq]

(Submitter supplied) The p300 lysine acetyltransferase (KAT) can function as an oncogene or a tumor suppressor in hematologic malignancies. We have identified a tumor suppressor role for p300 in myelodysplastic syndrome (MDS) driven by Tet2 deficiency. Compared to Tet2-null hematopoietic stem and progenitor cells (HSPCs), HSPCs lacking both p300 and Tet2 (double knock out, DKO) displayed enhanced proliferation and impaired differentiation. more...