GSM4693828[Accession] - GEO DataSets

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Items: 4

Select item 2001550251.

H-NS-like proteins in Pseudomonas aeruginosa coordinately silence intragenic transcription

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Pseudomonas aeruginosa PAO1

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL28916 GPL18782
36 Samples

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Accession:: GSE155025

ID:: 200155025

PubMed Full text in PMC Similar studies

Select item 2001550242.

H-NS-like proteins in Pseudomonas aeruginosa coordinately silence intragenic transcription [ChIP-seq]

(Submitter supplied) The H-NS-like proteins MvaT and MvaU act coordinately as global repressors in Pseudomonas aeruginosa by binding to AT-rich regions of the chromosome. Although cells can tolerate the loss of either protein, identifying their combined regulatory effects has been challenging because the loss of both proteins is lethal due to induction of prophage Pf4 and subsequent superinfection of the cell. In other bacteria, H-NS promotes cellular fitness by inhibiting intragenic transcription from AT-rich target regions, preventing them from sequestering RNA polymerase; however, it is not known if whether MvaT and MvaU function similarly. more...