GEO DataSets

(Submitter supplied) STAG2, a member of cohesin, is one of the most recurrently mutated genes in human cancer. Here, we investigated STAG2 function in the context of Ewing sarcoma, an aggressive bone tumor driven by EWS-FLI1 oncogene chimeric transcription factor. We transfected A673 cell line with siCT or 2 differents siSTAG2 (siSA2#6 or siSA2#8) during 72h. The cells were profiled by ChIP-seq for EWS-FLI1, CTCF, cohesin members and H3K27ac marks and highlighted a global conservation of binding for these marks upon STAG2 knock-down

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL24676

21 Samples

Download data: BED

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by array

Platforms:

GPL16791 GPL16311 GPL24676

336 Samples

Download data: BED, CEL, MATRIX, TAB