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Items: 4

1.

PALI1 Promotes Tumor Growth through Competitive Recruitment of PRC2 to G9A-target Chromatin for Dual Epigenetic Silencing [ChIP-seq]

(Submitter supplied) PALI1 is a newly identified accessory protein of the Polycomb Repressive Complex 2 (PRC2) that catalyzes H3K27 methylation. However, the roles of PALI1 in cancer are yet to be defined. Here we report that PALI1 is upregulated in advanced prostate cancer (PCa) and competes with JARID2 for binding to PRC2 core subunit SUZ12. PALI1 further interacts with the H3K9 methyltransferase G9A, bridging the formation of a unique G9A-PALI1-PRC2 super-complex that occupies a subset of G9A-target genes to mediate dual H3K9/K27 methylation and gene repression. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL15456
27 Samples
Download data: BW
Series
Accession:
GSE212625
ID:
200212625

PubMed Full text in PMC Similar studies

2.

PALI1 Promotes Tumor Growth through Competitive Recruitment of PRC2 to G9A-target Chromatin for Dual Epigenetic Silencing

(Submitter supplied) PALI1 is a newly identified accessory protein of the Polycomb Repressive Complex 2 (PRC2) that catalyzes H3K27 methylation. However, the roles of PALI1 in cancer are yet to be defined. Here we report that PALI1 is upregulated in advanced prostate cancer (PCa) and competes with JARID2 for binding to PRC2 core subunit SUZ12. PALI1 further interacts with the H3K9 methyltransferase G9A, bridging the formation of a unique G9A-PALI1-PRC2 super-complex that occupies a subset of G9A-target genes to mediate dual H3K9/K27 methylation and gene repression. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL15456 GPL20301
54 Samples
Download data: BW
Series
Accession:
GSE175697
ID:
200175697

PubMed Full text in PMC Similar studies

3.

Illumina HiScanSQ (Homo sapiens)

Organism:
Homo sapiens
122 Series
2006 Samples
Download data
Platform
Accession:
GPL15456
ID:
100015456

4.

siG9a_G9a ChIP-seq_Rep2

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541894
ID:
306541894

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db=gds|term=GSM6541894[Accession]|query=1|qty=2|blobid=MCID_674fa03e68e51b28f584e8ad|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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