GSM6568649[Accession] - GEO DataSets

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Items: 4

Select item 2002130181.

Lung endothelial cells regulate pulmonary fibrosis through FOXF1/R-Ras signaling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL17021 GPL24676
7 Samples

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Series

Accession:: GSE213018

ID:: 200213018

PubMed Full text in PMC Similar studies

Select item 2002130162.

Lung endothelial cells regulate pulmonary fibrosis through FOXF1/R-Ras signaling (Mouse I).

(Submitter supplied) Pulmonary fibrosis results from dysregulated repair of damaged tissue caused by persistent injury of lung epithelium. Multiple cell types in the lung are involved in the process of repair. During lung fibrogenesis, normal endothelial cells (EC) are re-programmed into fibrosis-associated EC. Transcriptional factors that control re-programming are poorly understood. Using single cell RNA-sequencing of EC from donor and idiopathic pulmonary fibrosis (IPF) lungs, and lungs from bleomycin-treated mice, we identified endothelial transcription factors (TF) that were differentially expressed during fibrosis. more...