GSM739149[Accession] - GEO DataSets

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Items: 4

Select item 2000298281.

Expression Profiling of Mixed Lineage Leukemia Cells Treated with a Potent Small-Molecule DOT1L Inhibitor

(Submitter supplied) Cell lines bearing MLL translocations (MV4-11 and MOLM-13) were treated with a potent, selective inhibitor of the DOT1L histone methyl transferase. Treatment of MLL-rearranged cell lines with the DOT1L inhibitor selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Here we provide expression profiling data of cells treated with DOT1L inhibitor or vehicle control.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4290
Platform:: GPL570
24 Samples

Download data: CEL

Series

Accession:: GSE29828

ID:: 200029828

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 42902.

Small-molecule DOT1L inhibitor EPZ004777 effect on mixed lineage leukemia cells: time course

Temporal analysis of mixed lineage leukemia (MLL)-rearranged cell lines MV4-11 and MOLM-13 treated with EPZ004777, a potent inhibitor of DOT1L histone methyl transferase. EPZ004777 induces differentiation and apoptosis in MLL-rearranged cells. Results provide insight into role of DOT1L in MLL cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 2 cell line, 3 time sets

Platform:: GPL570
Series:: GSE29828
24 Samples

Download data: CEL

DataSet

Accession:: GDS4290

ID:: 4290

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...