GSM8193562[Accession] - GEO DataSets

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Items: 3

Select item 2002634961.

Deciphering Mycobacterium tuberculosis glycan epitopes through clustering of human polyclonal and isolating novel monoclonal antibodies I

(Submitter supplied) The immunomodulatory mycobacterial surface antigen lipoarabinomannan (LAM) with its immunogenic glycan component arabinomannan (AM) facilitates Mycobacterium tuberculosis’ (Mtb) escape from the host’s immune response. Some but not all antibodies against AM can protect against TB. To better understand which of AM’s structures to target, we must first identify the spectrum of its epitopes. We here used synthetic AM oligosaccharide motifs to deplete sera from subjects along the spectrum of Mtb infection. more...

Organism:: synthetic construct; Homo sapiens

Type:: Protein profiling by protein array

Platform:: GPL34369
107 Samples

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Accession:: GSE263496

ID:: 200263496

Analyze with GEO2R

Select item 1000343692.

LAM Subarray 30 - Antigens

(Submitter supplied) Microarray slides were printed at Engineering Arts LLC (Phoenix, AZ). BSA conjugates were noncontact printed on Schott type E slides (Schott North America, Inc., Elmsford, NY) using an Engineering Arts au301 Rainmaker microarray printer and dispensed at 100 μg/mL in buffer (1:10 phosphate-buffered saline plus 0.005% vol/vol Triton X-100). Antigens were dispensed at 360 pL per spot to produce 140- to 160-m diameter spots in triplicate. more...