GSM838032[Accession] - GEO DataSets

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Items: 4

Select item 2000565041.

Loss of nuclear TDP-43 in ALS causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6193 GPL5188
42 Samples

Download data: CEL

Series

Accession:: GSE56504

ID:: 200056504

Select item 2000338552.

Loss of nuclear TDP-43 in ALS causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons [fibroblasts]

(Submitter supplied) Aims: Loss of nuclear TDP-43 characterises sporadic and most familial forms of amyotrophic lateral sclerosis (ALS). TDP-43 (encoded by TARDBP) has multiple roles in RNA processing. We aimed to determine whether 1) RNA splicing dysregulation is present in lower motor neurons in ALS and in a motor neuron-like cell model, and 2) TARDBP mutations (mtTARDBP) are associated with aberrant RNA splicing using patient-derived fibroblasts. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5188
19 Samples

Download data: CEL

Series

Accession:: GSE33855

ID:: 200033855

Select item 1000051883.

[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html #%create_date=Wed Mar 11 17:51:22 2009 PDT #%chip_type=HuEx-1_0-st-v2 #%lib_set_name=HuEx-1_0-st #%lib_set_version=v2 #%genome-species=Homo sapiens #%genome-version=hg18 #%genome-version-ucsc=hg18 #%genome-version-ncbi=36 #%genome-version-create_date=2006-03 #%netaffx-annotation-date=2009-03-16 #%netaffx-annotation-netaffx-build=28 Protocol: See manufacturer's web site