GEO DataSets

(Submitter supplied) In this study our aim was to document recurrent DNA copy number aberration associated breakpoints in primary tumors of colorectal cancer patients that ultimately received systemic treatment in the context of metastatic disease. Such data can be used to catalogue copy number aberration associated breakpoints and thereby affected genes. To this end, high quality arrayCGH data set of clinically well annotated colorectal cancer specimens was generated using FFPE tumor samples from patients from two phase III clinical trials, namely CAIRO and CAIRO2.

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platforms:

GPL8687 GPL16694

352 Samples

Download data: TXT

(Submitter supplied) Response to drug therapy in individual colorectal cancer (CRC) patients is associated with tumor biology. Here we describe the genomic landscape of tumor samples of a homogeneous well-annotated series of patients with metastatic CRC of two phase III clinical trials, CAIRO and CAIRO2. DNA copy number aberrations of 349 patients are determined. Within three treatment arms, 194 chromosomal sub-regions are associated with progression free survival PFS (uncorrected single-test p-values < 0.005). more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL8687

349 Samples

Download data: TXT

(Submitter supplied) 170k BaBo UMCG plus Cancer Census. Arrays of this design have barcodes that begin with 16022522 or 2522522. Protocol: see manufacturer's web site at http://www.agilent.com/

Organism:

Homo sapiens

20 Series

846 Samples

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