GSM99621[Accession] - GEO DataSets

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Items: 4

Select item 2000044271.

Methylation induced by the RAS oncogene

(Submitter supplied) Silencing of gene expression by methylation of CpG islands in regulatory elements is frequently observed in cancer. However, an influence of the most common oncogenic signalling pathways onto DNA methylation has not yet been investigated thoroughly. To address this issue, we identified genes suppressed in HRAS-transformed rat fibroblasts but up-regulated after treatment with the demethylating agent 5-Aza-CdR and with the MEK1,2 inhibitor U0126. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS1801
Platform:: GPL85
6 Samples

Download data: DAT, EXP

Series

Accession:: GSE4427

ID:: 200004427

Select item 18012.

DNA methyltransferase inhibitor 5-aza-2-deoxycytidine effect on RAS-transformed fibroblasts

Expression profiling of HRAS oncogene transformed fibroblasts after treatment with the DNA methyltransferase inhibitor 5-aza-2-deoxycytidine for 96 hours. Results provide insight into the role of DNA methylation in oncogenic signaling pathways.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 2 cell line sets

Platform:: GPL85
Series:: GSE4427
6 Samples

Download data: DAT, EXP

DataSet

Accession:: GDS1801

ID:: 1801

Select item 1000000853.

[RG_U34A] Affymetrix Rat Genome U34 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The RG-U34 set includes 3 arrays with a total of 26379 entries and was indexed 29-Jan-2002. more...