GEO DataSets

(Submitter supplied) We sought to determine how CovRS mutations varying CovR phosphorylation levels affect the gene expression profile of group A streptococcus

Organism:

Streptococcus sp. 'group A'

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19691

32 Samples

Download data: TXT

(Submitter supplied) We sought to determine how deletion of ccpA affects the gene expression profile in three M serotype strains of group A streptococcus

Organism:

Streptococcus sp. 'group A'

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19691

24 Samples

Download data: TXT

(Submitter supplied) We sought to determine how single amino acid changes in the active site of CovS autophosphorylation and subsequent phosphorylation of the response regulator CovR affect the gene expression profile of group A streptococcus

Organism:

Streptococcus sp. 'group A'

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19691

24 Samples

Download data: TXT

(Submitter supplied) Group A Streptococcus (GAS) has a rich evolutionary history of horizontal transfer among its core genes. Yet, despite extensive genetic mixing, GAS strains have discrete ecological phenotypes. To further our understanding of the molecular basis for ecological phenotypes, comparative genomic hybridization of a set of 97 diverse strains to a GAS pan-genome microarray was undertaken, and the association of accessory genes with emm genotypes that define tissue tropisms for infection was determined. more...

Organism:

Streptococcus sp. 'group A'

Type:

Genome variation profiling by array

Platform:

GPL14371

97 Samples

Download data: MEV

(Submitter supplied) The goal of this study were to compare the transcriptoms of CcpA and CovR in group A Streptococcus. Isogenic mutant strains were created in which CcpA and CovR were inactivated alone and in combination. The transcriptomes of the four strains (wild-type, CcpA mutant, CovR mutant, and ccpA-covR double mutant) were then compared.

Organism:

Streptococcus sp. 'group A'; Streptococcus pyogenes

Type:

Expression profiling by array

Platform:

GPL9080

32 Samples

Download data: CEL

(Submitter supplied) The molecular genetic mechanisms used by bacteria to persist in humans are poorly understood. Group A Streptococcus (GAS) causes the majority of bacterial pharyngitis cases in humans and is prone to persistently inhabit the upper respiratory tract. To gain information about how GAS survives in and infects the oropharynx, we analyzed the transcriptome of a serotype M1 strain grown in saliva. The dynamic pattern of changes in transcripts of genes [spy0874/0875, herein named sptR and sptS (sptR/S), for saliva persistence] encoding a two-component gene regulatory system of unknown function suggested that SptR/S contributed to persistence of GAS in saliva. more...

Organism:

Coxiella burnetii; Streptococcus pyogenes; Yersinia pestis; Streptococcus sp. 'group A'; Borreliella burgdorferi; Chlamydia trachomatis; Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL2129

16 Samples

Download data: CEL

(Submitter supplied) This study evaluate how catabolite control protein A (CcpA) inactivation affected gene transcript levels in the group A Streptococcus serotype M1 strain MGAS5005 during growth in standard laboratory medium. Keywords: transcriptome analysis

Organism:

Streptococcus pyogenes; Streptococcus sp. 'group A'

Type:

Expression profiling by array

Platform:

GPL6186

16 Samples

Download data: CEL

(Submitter supplied) Epidemiological data indicate that strains MGAS315 and MGAS9887 differ significantly in their capacity to cause necrotizing fasciitis infections. To probe the hypothesis that this difference was associated with differences in gene expression, an expression MA comparison of the strains in exponential phase growth in rich media was conducted. Keywords: strain comparison

Organism:

Borreliella burgdorferi; Chlamydia trachomatis; Staphylococcus aureus; Yersinia pestis; Streptococcus sp. 'group A'; Coxiella burnetii; Streptococcus pyogenes

Type:

Expression profiling by array

Dataset:

GDS2353

Platform:

GPL2129

12 Samples

Download data: CEL, EXP

Analysis of group A Streptococcus M3 strains MGAS315 and MGAS9887. MGAS9887 is underrepresented among necrotizing fasciitis cases and has a truncated MtsR transcriptional regulator. Results provide insight into the molecular basis of the differences in virulence between the strains.

Organism:

Borreliella burgdorferi; Yersinia pestis; Coxiella burnetii; Chlamydia trachomatis; Staphylococcus aureus; Streptococcus pyogenes; Streptococcus sp. 'group A'

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL2129

Series:

GSE3966

12 Samples

Download data: CEL, EXP

(Submitter supplied) Pan-genome microarray was constructed using Alab49 as the reference. PCR primers were designed for predicted genes in Alab49 using Primer3, followed by 11 subsequent strains not already represented by Alab49 and were tested for uniqueness using in-house scripts. The resulting 3388 amplicons ranged in size from 51 to 1170 bp; all of these were amplified using 10X PCR Buffer, MgCl2, 100mM dNTP mix, Taq Polymerase, and water (all Applied Biosystems). more...

Organism:

Streptococcus sp. 'group A'

1 Series

97 Samples

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