Similar studies for GEO DataSets (Select 1544) - GEO DataSets

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Items: 20

Select item 15441.

Ionizing radiation effect on lymphoid tissue of ATM protein kinase deficient mutants

Analysis of lymph nodes from ATM-deficient males exposed to ionizing radiation (IR). ATM regulates the cellular network induced by DNA double-strand breaks and is often mutated in lymphoid tumors. Results identify parallel induction of ATM-dependent pro- and antiapoptotic signals in response to IR.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation, 2 stress, 3 time sets

Platform:: GPL81
Series:: GSE2118
14 Samples

Download data: CEL

DataSet

Accession:: GDS1544

ID:: 1544

Select item 2000021182.

IR-response in Atm-/- and control lymph nodes

(Submitter supplied) The DNA damage response network modulates a wide array of signaling pathways, including DNA repair, cell cycle checkpoints, apoptotic pathways and numerous stress signals. The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia (A-T), is a master regulator of this network when the inducing DNA lesions are double strand breaks. The ATM gene is also frequently mutated in sporadic cancers of lymphoid origin. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1544
Platform:: GPL81
14 Samples

Download data: CEL

Series

Accession:: GSE2118

ID:: 200002118

Select item 2000231163.

Microarray analysis of gene expression in ATM-deficient MEFs

(Submitter supplied) The expression of interferon-related genes was more enhanced in irradiated ATM-deficient mouse embryonic fibroblasts (MEFs) than in irradiated ATM wild-type MEFs.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
12 Samples

Download data: TXT

Series

Accession:: GSE23116

ID:: 200023116

Select item 2000135974.

Expression data from biopsies of Nasopharyngeal carcinoma (NPC) and non-malignant controls

(Submitter supplied) Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and South East Asia where more than 50,000 new cases are diagnosed each year. We used microarrays to identify down or upregulated genes in NPC compared with non-malignant controls. Keywords: Diseased versus control

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3610
Platform:: GPL96
28 Samples

Download data: CEL, CHP

Series

Accession:: GSE13597

ID:: 200013597

Select item 36105.

Nasopharyngeal carcinoma

Analysis of biopsies from patients with Epstein-Barr virus (EBV)-positive undifferentiated nasopharyngeal carcinoma (NPC). NPC is a common cancer in China and Southeast Asia. Results provide insight into the molecular pathogenesis of NPC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL96
Series:: GSE13597
28 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3610

ID:: 3610

Select item 2000016766.

DNA damage response (NCS treatment) in several siRNA-manipulated cellular systems

(Submitter supplied) Response to treatment with the radiomimetic drug NCS in cells knocked-down for ATM, p53, and the Rel_A subunit of NFkB; and in control un-infected cells and cells infected with siRNA against LacZ Keywords = DNA damage Keywords = ATM Keywords = p53 Keywords = RelA Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1852
Platform:: GPL201
30 Samples

Download data: CEL

Series

Accession:: GSE1676

ID:: 200001676

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 18527.

siRNA knockdown and transcriptional response to DNA damage

Analysis of HEK293 cells following siRNA knockdown of p53, RelA, or ATM, and subsequent treatment with neocarzinostatin, a radiomimetic drug that induces DNA double-strand breaks. Results indicate RNAi combined with expression profiling is a powerful method for dissecting transcriptional networks.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 5 protocol sets

Platform:: GPL201
Series:: GSE1676
30 Samples

Download data: CEL

DataSet

Accession:: GDS1852

ID:: 1852

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000062378.

Fine temporal analysis of DHT transcriptional modulation of the ATM/Gadd45g signaling pathways in the mouse uterus.

(Submitter supplied) In rodents, the uterus of a mature female undergoes changes during the uterine cycle, under the control of steroid hormones. 5a-Dihydrotestosterone (DHT) is recognized to play an important role in the regulation of androgen action in normal endometrium. Using microarray technology, a screening analysis of genes responding to DHT in the uterus of ovariectomized mice, has allowed us to highlight multiple genes of the ATM/Gadd45g pathway that are modulated following exposure to DHT. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL81
7 Samples

Download data: CEL

Series

Accession:: GSE6237

ID:: 200006237

Select item 2000031749.

ATM Requirement in Gene Expression Responses to Ionizing Radiation in Human Lymphoblasts and Fibroblasts

(Submitter supplied) Investigation of ATM-dependent and dose-dependent, or -independent, responses were examined in human lymphoblast cells 6 hr following exposure to either 1 or 5 Gy ionizing radiation. Keywords: cDNA, dual-channel

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL2768 GPL2710
56 Samples

Download data

Series

Accession:: GSE3174

ID:: 200003174

Select item 20000095310.

Effect of TERT and ATM on Gene Expression Profiles in Human Fibroblasts

(Submitter supplied) Gene expression profiling was performed by use of serial analysis of gene expression (SAGE) on BJ normal human skin fibroblasts, A-T cells, and BJ and A-T cells transduced with hTERT cDNA and expressing telomerase activity. Keywords = telomere Keywords = telomerase Keywords = TERT Keywords = ataxia telangiectasia mutated Keywords = ATM Keywords = serial analysis of gene expression Keywords = SAGE Keywords = fibroblast Keywords: parallel sample

Organism:: Homo sapiens

Type:: Expression profiling by SAGE

Platform:: GPL4
4 Samples

Download data

Series

Accession:: GSE953

ID:: 200000953

PubMed Similar studies

Select item 20004585011.

Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals and AT patients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL7260 GPL887 GPL7264
88 Samples

Download data: TXT

Series

Accession:: GSE45850

ID:: 200045850

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004584912.

Gene expressioin signatures in human lymphoblastoid cell lines with different ataxia telangiectasia-mutated (ATM) genotypes post sham- or IR-treatment

(Submitter supplied) Transcriptional profiling of human lymphoblastoid cell lines with different ATM genotypes 6h post sham- or 1.5 Gy IR-treatmentl was compared to extract IR-related gene expression signatures that can identify ataxia telangiectasia (AT) carries from non AT carries and AT patients.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL7264 GPL7260
64 Samples

Download data: TXT

Series

Accession:: GSE45849

ID:: 200045849

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004584813.

Gene expressioin signatures at basal level in human lymphoblastoid cell lines with different ataxia telangiectasia-mutated (ATM) genotypes

(Submitter supplied) Transcriptional profiling of human lymphoblastoid cell lines with different ATM genotypes at basal level was compared to extract gene expression signatures that can identify ataxia telangiectasia (AT) carries from non AT carries and AT patients.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL887
24 Samples

Download data: TXT

Series

Accession:: GSE45848

ID:: 200045848

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000798114.

sade-catma-A functional study of genes that might play a role in DNA repair/recombination and in the response ...

(Submitter supplied) af51_atm - sade-catma - which Arabidopsis thaliana genes are induced by ionising radiations? Comparison of SADE transcriptome data (Af1999083) and micro-arrays transcriptome data. - gamma rays irradiated vs non irradiated 4 days old seedlings Keywords: treated vs untreated comparison

Organism:: Arabidopsis thaliana

Type:: Expression profiling by array

Platform:: GPL5337
6 Samples

Download data: GPR

Series

Accession:: GSE7981

ID:: 200007981

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000798015.

atm-root-A functional study of genes that might play a role in DNA repair/recombination and in the response to...

(Submitter supplied) af51_atm - atm-root - which Arabidopsis thaliana genes are induced by ionising radiations? Comparison of SADE transcriptome data (Af1999083) and micro-arrays transcriptome data. - Gamma rays irradiated vs non irradiated 3 or 4-days old seedlings Keywords: treated vs untreated comparison

Organism:: Arabidopsis thaliana

Type:: Expression profiling by array

Platform:: GPL5337
12 Samples

Download data: GPR

Series

Accession:: GSE7980

ID:: 200007980

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000797916.

atm time course-A functional study of genes that might play a role in DNA repair/recombination and in the resp...

(Submitter supplied) af51_atm - atm time course - which Arabidopsis thaliana genes are induced by ionising radiations? Comparison of SADE transcriptome data (Af1999083) and micro-arrays transcriptome data. - which Arabidopsis thaliana genes are induced by ionising radiations ? time course: 0.75h, 1.5h, 3h, 5h dose: Gamma rays irradiated vs non irradiated 4-days old seedlings Keywords: time course

Organism:: Arabidopsis thaliana

Type:: Expression profiling by array

Platform:: GPL5337
20 Samples

Download data: GPR

Series

Accession:: GSE7979

ID:: 200007979

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003024017.

Expression data from 5 human cell lines exposed to IR (5 Gy)

(Submitter supplied) The cellular response to DNA damage is vital for maintaining genomic stability and preventing undue cell death or cancer formation. The DNA damage response (DDR), most robustly mobilized by double-strand breaks (DSBs), rapidly activates an extensive signaling network that affects numerous cellular systems, leading to cell survival or programmed cell death. A major component of the DDR is the widespread modulation of gene expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
75 Samples

Download data: CEL, CHP

Series

Accession:: GSE30240

ID:: 200030240

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000902418.

Gene activation by Rag-mediated DNA double strand breaks

(Submitter supplied) The objective is to identify genes that are differentially expressed following the introduction of DNA double strand breaks (DSBs) by the Rag proteins in murine pre-B cells. Cells lacking Artemis are used since the Rag-induced DSBs will not be repaired and, thus, will provide a continuous stimulus to the cell. Cells lacking Artemis and Atm are used to determine which gene expression changes depend on Atm and cells lacking Artemis that express an I kappa B alpha dominant negative are used to determine which gene expression changes depend on NFkB.