GEO DataSets

Analysis of slbo mutant border and centripetal migratory cells in the ovary. SLBO, a C/EBP family transcriptional activator, is required for the switch from stationary to migratory behavior. Results identify genes involved in cell migration and downstream targets of SLBO.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 cell type, 2 genotype/variation sets

Platform:

GPL72

Series:

GSE4235

12 Samples

Download data: CEL

(Submitter supplied) Cell migration contributes to normal development and homeostasis as well as to pathological processes such as inflammation and tumor metastasis. Previous genetic screens have revealed a few major signaling pathways that govern follicle cell migrations in the Drosophila ovary, several of which elicit transcriptional responses. However few downstream targets of the critical transcriptional regulators, such as the C/EBP homolog SLBO, have been identified. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS1877

Platform:

GPL72

12 Samples

Download data: CEL

(Submitter supplied) Epithelial tube morphogenesis requires precise orchestration of cell signaling, shape, migration, and adhesion. Follicle cells in the Drosophila ovary form epithelial tubes, the lumens of which act as molds for the eggshell respiratory filaments, or dorsal appendages (DAs). The Tramtrack69 (TTK69) transcription factor controls DA lumen volume and shape by promoting tube expansion; the tramtrack mutation twin peaks (ttk^twk) reduces TTK69 levels late in oogenesis, inhibiting DA tube expansion. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

6 Samples

Download data: CEL

(Submitter supplied) gene expression is tested for an association with GSCs by comparing expression levels in ovary tips of c587-GAL4; hs-bam UAS-dpp females at 0 hr, 20 hr and 50 hr after heat shock ; results of two independent experiments are given as expt 1 and expt 2 Keywords: time course, heat shock, bam overexpression

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS1906

Platform:

GPL72

6 Samples

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(Submitter supplied) This series compares gene expression between germ line stem cells (GSCs) purified either from bam mutant or Dpp-overexpressing ovaries, with gene expression in Kc cells Keywords: bam mutant, Dpp overexpression

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS1905

Platform:

GPL72

9 Samples

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Analysis of Dpp expanded germ line stem cells (GSCs) at various time points up to 50 hours following transient bam gene induction. GSCs differentiate into cystocytes 20 hours following bam induction. Cystocytes revert to GSCs 30 hours later. Results identify candidate GSC-specific genes.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 cell type, 2 protocol, 3 time sets

Platform:

GPL72

Series:

GSE2784

6 Samples

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Analysis of purified ovarian germ line stem cells (GSCs) expanded by overexpression of the bone morphogenetic protein Dpp or by mutating the bam gene. Kc tissue culture cells also examined. Dpp represses bam transcription. Results provide insight into the mechanisms of GSC maintenance and function.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 cell type, 3 genotype/variation sets

Platform:

GPL72

Series:

GSE2783

9 Samples

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(Submitter supplied) Although the JAK/STAT pathway regulates numerous processes in vertebrates and invertebrates through modulating transcription, its functionally-relevant transcriptional targets remain largely unknown. With one jak and one stat (stat92E), Drosophila provides a powerful system for finding new JAK/STAT target genes. Genome-wide expression profiling on eye discs in which Stat92E is hyperactivated, revealed 584 differentially-regulated genes, including known targets domeless, socs36E and wingless. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

10 Samples

Download data: CEL

(Submitter supplied) Cell migration is an instrumental process that ensures cells are properly positioned to support the specification of distinct tissue types during development. To provide insight, we used fluorescence activated cell sorting (FACS) to isolate two migrating cell types from the Drosophila embryo: caudal visceral mesoderm (CVM) cells, precursors of longitudinal muscles of the gut, and hemocytes (HCs), the Drosophila equivalent of blood cells. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17275

4 Samples

Download data: TXT

(Submitter supplied) In Drosophila, the glial cells missing (gcm) gene encodes a transcription factor that controls the determination of glial versus neuronal fate. In gcm mutants, presumptive glial cells are transformed into neurons and, conversely, when gcm is ectopically misexpressed, presumptive neurons become glia. Although gcm is thought to initiate glial cell development through its action on downstream genes that execute the glial differentiation program, little is known about the identity of these genes. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL70

16 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL5919 GPL72

35 Samples

Download data: CEL, SGR

(Submitter supplied) Myb-MuvB (MMB)/dREAM is a nine subunit complex first described in Drosophila as a repressor of transcription, dependent upon E2F2 and the RBFs. Myb, an integral member of MMB, curiously plays no role in the silencing of the test genes previously analyzed. Moreover, Myb plays an activating role in DNA replication in Drosophila egg chamber follicle cells. The essential functions for Myb are executed as part of MMB. more...

Organism:

Drosophila melanogaster

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL5919

5 Samples

Download data: CEL, SGR

(Submitter supplied) Myb-MuvB (MMB)/dREAM is a nine subunit complex first described in Drosophila as a repressor of transcription, dependent upon E2F2 and the RBFs. Myb, an integral member of MMB, curiously plays no role in the silencing of the test genes previously analyzed. Moreover, Myb plays an activating role in DNA replication in Drosophila egg chamber follicle cells. The essential functions for Myb are executed as part of MMB. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL72

30 Samples

Download data: CEL

(Submitter supplied) The homeobox genes of the orthodenticle (otd)/Otx family play conserved roles in embryogenesis of the head and brain. Gene replacement experiments show that the Drosophila otd gene and orthologous mammalian Otx genes are functionally equivalent, in that overexpression of either gene in null mutants of Drosophila or mouse can restore defects in cephalic and brain development. This suggests that otd and Otx genes can control a comparable subset of downstream target genes in either organism. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS23

Platform:

GPL70

16 Samples

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Analysis of the effects of overexpression of orthodenticle homeobox genes otd (Drosophila) and Otx2 (human) reveals evolutionary conservation. The otd/Otx2 homeobox genes play a role in embryogenesis of the head and brain.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 shock, 3 strain sets

Platform:

GPL70

Series:

GSE32

16 Samples

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(Submitter supplied) The discovery of direct downstream targets of transcription factors (TFs) is necessary for understanding the genetic mechanisms underlying complex, highly regulated processes such as development. In this report, we have used a combinatorial strategy to conduct a genome-wide search for novel direct targets of Eyeless (Ey), a key transcription factor controlling early eye development in Drosophila. Like many other TFs, little is known for Ey direct downstream targets. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS1977

Platform:

GPL1322

25 Samples

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Analysis of leg, wing, and antenna imaginal discs ectopically expressing the retinal determination protein (RD) Eyeless (Ey) in the atonal wild-type or mutant background. Genes that depend on atonal for expression are involved in processes occurring after RD. Results identify targets of Ey.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, transformed count, 3 genotype/variation, 4 tissue sets

Platform:

GPL1322

Series:

GSE4008

25 Samples

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(Submitter supplied) Here we used laser cutting microdissection and RNA amplification to profile the gene expression in wildtype female germaria and male apex of the testes. These tissue contain germline stem cells and early dividing germ cells. Our goal was to identify genes expressed in these cell types.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL3880

4 Samples

Download data: GPR

(Submitter supplied) We performed genome-wide profiling experiments on tissues from Drosophila melanogaster adult females with a mutation in the p24 gene logjam (loj) to test the hypothesis that loss of loj function causes a transcriptional response characteristic of ER stress activation. Keywords: logjam mutant compared to control

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS3633

Platform:

GPL1322

12 Samples

Download data: CEL

Analysis of abdominal and head/thorax segments of mutants lacking p24. Members of the p24 protein family are transmembrane constituents of the ER and Golgi-derived transport vesicles that function in trafficking secretory proteins. Results provide insight into the effect of the loss of p24 function.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL1322

Series:

GSE10940

12 Samples

Download data: CEL