Similar studies for GEO DataSets (Select 1906) - GEO DataSets

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Items: 20

Select item 19061.

Ovarian germ line stem cell differentiation and reversion: time course

Analysis of Dpp expanded germ line stem cells (GSCs) at various time points up to 50 hours following transient bam gene induction. GSCs differentiate into cystocytes 20 hours following bam induction. Cystocytes revert to GSCs 30 hours later. Results identify candidate GSC-specific genes.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 2 cell type, 2 protocol, 3 time sets

Platform:: GPL72
Series:: GSE2784
6 Samples

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DataSet

Accession:: GDS1906

ID:: 1906

Select item 2000027842.

GSC differentiation-reversion test

(Submitter supplied) gene expression is tested for an association with GSCs by comparing expression levels in ovary tips of c587-GAL4; hs-bam UAS-dpp females at 0 hr, 20 hr and 50 hr after heat shock ; results of two independent experiments are given as expt 1 and expt 2 Keywords: time course, heat shock, bam overexpression

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS1906
Platform:: GPL72
6 Samples

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Series

Accession:: GSE2784

ID:: 200002784

Select item 2000027833.

GSC vs Kc

(Submitter supplied) This series compares gene expression between germ line stem cells (GSCs) purified either from bam mutant or Dpp-overexpressing ovaries, with gene expression in Kc cells Keywords: bam mutant, Dpp overexpression

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS1905
Platform:: GPL72
9 Samples

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Series

Accession:: GSE2783

ID:: 200002783

Select item 19054.

Ovarian germ line stem cells expanded by Dpp overexpression and bam mutation

Analysis of purified ovarian germ line stem cells (GSCs) expanded by overexpression of the bone morphogenetic protein Dpp or by mutating the bam gene. Kc tissue culture cells also examined. Dpp represses bam transcription. Results provide insight into the mechanisms of GSC maintenance and function.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 2 cell type, 3 genotype/variation sets

Platform:: GPL72
Series:: GSE2783
9 Samples

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DataSet

Accession:: GDS1905

ID:: 1905

Select item 2000226865.

Expression analysis of laser cut germaria vs laser cut apex of testes

(Submitter supplied) Here we used laser cutting microdissection and RNA amplification to profile the gene expression in wildtype female germaria and male apex of the testes. These tissue contain germline stem cells and early dividing germ cells. Our goal was to identify genes expressed in these cell types.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL3880
4 Samples

Download data: GPR

Series

Accession:: GSE22686

ID:: 200022686

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000069286.

Stonewalling Drosophila stem cell differentiation by epigenetic controls

(Submitter supplied) Abstract: During Drosophila oogenesis, germline stem cell (GSC) identity is maintained largely by preventing the expression of factors that promote differentiation. This is accomplished via the activity of several genes acting either in the GSC or its niche. The translational repressors, Nanos and Pumilio, act in GSCs to prevent differentiation, likely by inhibiting translation of early differentiation factors, while niche signals prevent differentiation by silencing transcription of the differentiation factor Bam. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS2734
Platform:: GPL1322
6 Samples

Download data: CEL

Series

Accession:: GSE6928

ID:: 200006928

Select item 27347.

DNA-associated protein Stonewall deficiency effect on ovaries

Comparison of ovaries from bag of marbles (bam) mutants and stonewall (stwl) bam double mutants. Stwl is a DNA-associated protein required for germline stem cell (GSC) maintenance; Bam is a key differentiation factor. Results provide insight into the role of Stwl in maintaining germ cell identity.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL1322
Series:: GSE6928
6 Samples

Download data: CEL

DataSet

Accession:: GDS2734

ID:: 2734

Select item 2001428308.

microRNA expression analysis in fly ovaries from wuho and mei-p26 mutants

(Submitter supplied) Purpose: The goal of this study is to analyze microRNA affected by wuho and mei-p26 mutations in Drosophila ovary Ovarian microRNA prolife of 7 day old control flies and flies bearing wuho and mei-p26 mutations, in duplicate.Sample libraries were prepared using the QIAseq miRNA Library Kit (QIAGEN) according to the manufacturer's protocols. Adaptors are ligated sequentially to the 3' and 5' ends of miRNAs. more...

Organism:: Drosophila melanogaster

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL19132
6 Samples

Download data: XLSX

Series

Accession:: GSE142830

ID:: 200142830

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001428299.

Gene expression analysis in fly ovaries from wuho mutant

(Submitter supplied) Purpose: The goal of this study is to analyze genes affected by wuho mutation in Drosophila ovary Ovarian mRNA prolife of 7 day old control flies and flies bearing wuho mutation, in duplicate, using Illumina NextSeq 500. The sequence reads that passed quality filters were analyzed at the transcript isoform level with two methods: Burrows–Wheeler Aligner (BWA) followed by ANOVA (ANOVA) and TopHat followed by Cufflinks.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19132
4 Samples

Download data: XLSX

Series

Accession:: GSE142829

ID:: 200142829

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20001696010.

Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq

(Submitter supplied) Both transcription and post-transcriptional processes, such as alternative splicing, play crucial roles in controlling developmental programs in metazoans. Recently emerged RNA-seq method has brought our understanding of eukaryotic transcriptomes to a new level, because it can resolve both gene expression level and alternative splicing events simultaneously. To gain a better understanding of cellular differentiation in gonads, we analyzed mRNA profiles from Drosophila testes and ovaries using RNA-seq. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9061
4 Samples

Download data: GRAPH, TXT

Series

Accession:: GSE16960

ID:: 200016960

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011986211.

Defining the Expression of piRNAs and Transposable Elements in Drosophila Ovarian Germline Stem Cells and Niche Cells

(Submitter supplied) Summary: Piwi-interacting RNAs (piRNAs) are important for repressing transposable elements (TEs) and modulating gene expression in germ cells, thereby maintaining genome stability and germ cell function. Here, we show that the canonical piRNA clusters are more active in GSCs (germline stem cells) and their early progeny than late germ cells, and identify new piRNA clusters using deep RNA sequencing. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17275
57 Samples

Download data: BED, XLS

Series

Accession:: GSE119862

ID:: 200119862

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013982812.

Drosophila YBX1 homolog YPS promotes ovarian germline stem cell development by preferentially recognizing 5-methylcytosine RNAs

(Submitter supplied) 5-Methylcytosine (m5C) is one of the most abundant RNA modifications, but its function in adult stem cell development remains poorly defined. This study shows that Ypsilon schachtel (YPS) promotes germ line stem cell (GSC) maintenance, proliferation, and differentiation in the adult Drosophila ovary by preferentially binding to m5C-containing RNAs. Highly conserved cold-shock domains (CSDs) of YPS and its human homolog Y box binding protein 1 (YBX1) exhibit preferential binding to m5C-containing RNAs through hydrophobic interactions. more...

Organism:: Drosophila melanogaster

Type:: Other

Platform:: GPL19132
6 Samples

Download data: BW

Series

Accession:: GSE139828

ID:: 200139828

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009675113.

Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms

(Submitter supplied) Purpose: Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through piRNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear if it plays any roles in early GSC lineage development. Results: The study reveals a novel function of Aub in GSCs and their progeny, which promotes translation of self-renewal and differentiation factors by directly binding to its target mRNAs and interacting with translational initiation factors.

Organism:: Drosophila melanogaster

Type:: Other

Platform:: GPL17275
3 Samples

Download data: BED

Series

Accession:: GSE96751

ID:: 200096751

PubMed Similar studies SRA Run Selector

Select item 20000423514.

Whole genome gene expression profiles of migratory cells in the Drosophila ovary

(Submitter supplied) Cell migration contributes to normal development and homeostasis as well as to pathological processes such as inflammation and tumor metastasis. Previous genetic screens have revealed a few major signaling pathways that govern follicle cell migrations in the Drosophila ovary, several of which elicit transcriptional responses. However few downstream targets of the critical transcriptional regulators, such as the C/EBP homolog SLBO, have been identified. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS1877
Platform:: GPL72
12 Samples

Download data: CEL

Series

Accession:: GSE4235

ID:: 200004235

Select item 187715.

slbo mutant migratory cells of the ovary

Analysis of slbo mutant border and centripetal migratory cells in the ovary. SLBO, a C/EBP family transcriptional activator, is required for the switch from stationary to migratory behavior. Results identify genes involved in cell migration and downstream targets of SLBO.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 2 cell type, 2 genotype/variation sets

Platform:: GPL72
Series:: GSE4235
12 Samples

Download data: CEL

DataSet

Accession:: GDS1877

ID:: 1877

Select item 20013197116.

A single cell atlas of the developing Drosophila ovary identifies follicle stem cell progenitors

(Submitter supplied) We use single cell RNA sequencing approach to identify and characterize all cell types in developing Drosophila ovaries at late third instar larval stage (LL3).

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21306
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE131971

ID:: 200131971

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20019589317.

Oo-site: A dashboard to visualize gene expression during Drosophila oogenesis reveals meiotic entry is regulated post-transcriptionally

(Submitter supplied) Determining how stem cell differentiation is controlled has important implications for understanding the etiology of degenerative disease and designing regenerative therapies. In vivo analyses of stem cell model systems have revealed regulatory paradigms for stem cell self-renewal and differentiation. The germarium of the female Drosophila gonad, which houses both germline and somatic stem cells, is one such model system. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19132
4 Samples

Download data: TAB

Series

Accession:: GSE195893

ID:: 200195893

PubMed Full text in PMC Similar studies

Select item 20019097018.

A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [bam-aramis double mRNAseq]

(Submitter supplied) Ribosomal defects perturb stem cell differentiation, causing diseases called ribosomopathies. How ribosome levels control stem cell differentiation is not fully known. Here, we discovered three RNA helicases are required for ribosome biogenesis and for Drosophila oogenesis. Loss of these helicases, which we named Aramis, Athos and Porthos, lead to aberrant stabilization of p53, cell cycle arrest and stalled GSC differentiation. more...