GEO DataSets

(Submitter supplied) Comparison of gene expression between T regulatory and T effector cells isolated from the pancreatic lesion of 3-4 wk old BDC2.5 tg NOD mice Keywords: cell type comparison

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS684

Platform:

GPL81

30 Samples

Download data: CEL

Comparison of T regulatory (CD4+CD25+CD69-) and T effector (CD4+CD25lo/-CD69+/-) cells isolated from the pancreatic lesion of 3-4 week old BDC2.5 transgenic NOD mice before type 1 diabetes onset.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell type sets

Platform:

GPL81

Series:

GSE1419

8 Samples

Download data: CEL

(Submitter supplied) The objective of the present study was to characterize the phenotype of CD4+CD25+Foxp3+ regulatory T cells (Tregs) in the course of parasitic Plasmodium yoelii (P .yoelii) infection of BALB/c mice. Therefore we performed microarray expression analysis of CD4+CD25+Foxp3+ Tregs isolated by FACS from spleens of non-infected mice and from spleens of mice infected with P. yoelii 3 days and 5 days post infection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

6 Samples

Download data: TXT

(Submitter supplied) Following Treg ablation in the BDC/NOD.Foxp3-DTR strain, NK cells produce IFNg and accumulate to higher percentage and number. We explored the signature pathways responsible for this phenomenon using microarray prolifing and comparison to other activation signatures.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4946 GDS4948

Platform:

GPL6246

41 Samples

Download data: CEL

Analysis of NOD-derived, splenic natural killer (NK) cells cultured with or without cytokines interleukin (IL)-12 + IL-18 in the absence of TGF-β, or with both cytokines in the presence of TGF-β. Results provide insight into the impact of TGF-β on NK cells independent of general activation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol, 2 time sets

Platform:

GPL6246

Series:

GSE39197

9 Samples

Download data: CEL

Analysis of natural killer (NK) cells isolated from the pancreas or spleen of BDC2.5/NOD.Foxp3DTR animals up to 24 hours after diphtheria toxin (DT) injection to ablate regulatory T (Treg) cells. Results provide insight into molecular mechanisms underlying Treg/NK cross-talk in controlling diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 3 time, 2 tissue sets

Platform:

GPL6246

Series:

GSE39197

32 Samples

Download data: CEL

(Submitter supplied) MBP TCR Tg mouse (1B3) generates only iTregs when crossed onto RAGKO background. Tregs from 1B3.RAG mouse were used for gene expression analsysis to determine genes selectively expressed in peripherally generated iTregs

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

42 Samples

Download data: TXT

(Submitter supplied) Treatment with anti-CD3 is a promising therapeutic approach for autoimmune diabetes, but its mechanism of action remains unclear. Foxp3+ regulatory T (Treg) cells may be involved, but the evidence has been conflicting, and there is great uncertainty as to possible mechanistic connections. We investigated this issue in mice derived from the NOD model, which were engineered mice in which Treg populations were perturbed, or could be manipulated by acute ablation or transfer. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4018

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of sorted spleen T cells of BDC2.5 RAGo/o Foxp3 NOD mice after anti-CD3 treatment. Anti-CD3 treatment prevented diabetes development in BDC2.5.RAGo/o mice. Results provide insight into the mechanism of action of anti-CD3.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE22527

6 Samples

Download data: CEL

(Submitter supplied) A microarray study performed in the pancreatic lymph nodes of Deaf1 knock-out and BALB/c control mice to identify genes that are regulated by the transcriptional regulator Deaf1. These experiments constitute a portion of the study described below: Abstract: Type 1diabetes (T1D) can result from a breakdown in peripheral tolerance which is controlled by peripheral tissue antigen (PTA) expression in lymph nodes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

2 Samples

Download data

(Submitter supplied) Immune-related adverse events (irAEs) are a notable complication of PD-1 cancer immunotherapy. A better understanding of how these iatrogenic diseases compare to naturally arising autoimmune diseases is needed for treatment and monitoring of irAEs. We identified differences in anti-PD-1-induced Type 1 Diabetes (T1D) and spontaneous T1D in non-obese diabetic (NOD) mice by performing single-cell RNA-seq and TCR-seq on T cells from the pancreas, pancreas-draining lymph node (pLN), and blood of mice with PD-1-induced T1D or spontaneous T1D. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL24247

27 Samples

Download data: CSV, MTX, RDS, TSV