GEO DataSets

(Submitter supplied) Myosine heavy chain I was overexpressed in mouse skeletal muscle. The transgenic mice, as well as the wild type mice, were endurance trained on treadmill for 5 days/week over 8 weeks at 80% peak aerobic capacity in comparison with untrained mice. The gene expression profiles of the skeletal muscles from wild-type trained (WTT) and untrained (WTUT), and transgenic trained (TGT) and untrained (TGUT) were measured using Affymetrix Mouse430A 2.0 GeneChips. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

20 Samples

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(Submitter supplied) We used gene microarray analysis to compare the global expression profile of genes involved in adaptation to exercise training in skeletal muscle from chronically strength/resistance trained (ST), endurance trained (ET) and untrained control subjects (Con). Resting skeletal muscle samples (~100mg) were obtained from the vastus lateralis of 20 subjects (Con n=7, ET n=7, ST n=6; trained groups >8 years specific training). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6042

21 Samples

Download data: GPR

(Submitter supplied) To investigate microRNAs related to mitochondria biogenesis in skeletal muscle, microRNA expressions during skeletal muscle differentiation and exercise were analyzed in vivo and in vitro.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL13533

6 Samples

Download data: GPR

(Submitter supplied) Skeletal muscle mitochondrial dysfunction is secondary to T2DM and can be improved by long-term regular exercise training Mitochondrial dysfunction has long been implicated to play a causative role in development of type 2 diabetes (T2DM). However, a growing number of recent studies provide data that mitochondrial dysfunction is a consequence of T2DM development. The aim of our study is to clarify in further detail the causal role of mitochondrial dysfunction in T2DM by a comprehensive ex vivo analysis of mitochondrial function combined with global gene expression analysis in muscle of pre-diabetic newly diagnosed untreated T2DM subjects and long-standing insulin treated T2DM subjects compared with age- and BMI-matched controls. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3880

Platform:

GPL570

42 Samples

Download data: CEL

Analysis of skeletal muscle biopsies from insulin-treated type 2 diabetes (T2D) subjects before/after exercise training, pre-diabetics and healthy controls. Results provide insight into the molecular basis of T2D, the role of mitochondrial dysfunction, and the effects of prolonged exercise training.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 34 individual, 3 protocol sets

Platform:

GPL570

Series:

GSE19420

42 Samples

Download data: CEL

(Submitter supplied) Background: Muscle responses to exercise are complex, and potentially include acute responses to exercise-induced injury as well as longer-term adaptive training responses. Using Alaskan sled dogs as an experimental model, changes in muscle gene expression were analyzed to better understand the temporal changes that occur after severe exercise. Methods: Dogs were randomly assigned to undertake in a 160 km run (n=9), or to remain at rest (n=4). more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL6800

13 Samples

Download data: TXT

(Submitter supplied) Aging is associated with mitochondrial dysfunction and insulin resistance. We conducted a study to determine the role of long-term vigorous endurance exercise on age-related changes in insulin sensitivity and various indices of mitochondrial functions. Keywords: The effect of excises in young and old human subjects by transcription profiling

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3182

Platform:

GPL570

40 Samples

Download data: CEL

Analysis of skeletal muscles from young and aged individuals undergoing vigorous endurance exercise training for over 4 years. Results provide insight into the effects of endurance exercise on age-related insulin resistance and mitochondrial dysfunction.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age, 2 protocol sets

Platform:

GPL570

Series:

GSE9103

37 Samples

Download data: CEL

(Submitter supplied) Purpose: The aim of this study is to investigate the translational regulation of skeletal muscle during acute endurance exercise. Methods: We used mRNA-Seq and ribosome profiling to examine transcriptional and translational regulation, respectively. Result: There were clear distinctions between the profiles of transcription and translation even at a basal condition. TOP-motif genes were translationally suppressed immediately after the exercise. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL16331

8 Samples

Download data: TXT

(Submitter supplied) Time course of mRNA after 30 minutes of endurance exercise at simulated altitude of 4000 m in an untrained or six weeks trained state of six subjects.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1935

44 Samples

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(Submitter supplied) Time course of mRNA after 30 minutes of endurance exercise in an untrained (1) or six weeks trained state (2) of six subjects (Hoxxx) Ho980: (1) GSM47111, GSM47112, GSM47113, GSM47114, (2) GSM47115, GSM47116, GSM47125, GSM47126 Ho983: (1) GSM47129, GSM47131, GSM47135, GSM47136, (2) GSM47139, GSM47142, GSM47144, GSM47145 Ho985: (1) GSM47146, GSM47147, GSM47148, GSM47149, (2) GSM47155, GSM47159, GSM47160, GSM47161 Ho995: (1) GSM47162, GSM47163, GSM47164, GSM47165, (2) GSM47166, GSM47167, GSM47168, GSM47169 Ho997: (1) GSM47170, GSM47171, GSM47172, GSM47173, (2) GSM47174, GSM47175, GSM47176, GSM47177 Ho999: (1) GSM47178, GSM47179, GSM47180, GSM47181, (2) GSM47182, GSM47185, GSM47195, GSM47196 Keywords: time-course

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1935

48 Samples

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(Submitter supplied) Gene expression profiles generated from skeletal muscle biopsies taken from participants of the HERITAGE family study. Participants completed an endurance training regime in which a skeletal muscle biopsy was taken prior to the start and after the final session of the program. Biopsies were used to generate Affymetrix gene expression microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

82 Samples

Download data: CEL

(Submitter supplied) Gastrocnemius muscle from Eif6 heterozygous mice and wild-type mice was used in a polysome profiling experiment. Total RNA was extracted from the whole muscle and from monosome/polysome fractions and profiled using Agilent gene expression arrays.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

16 Samples

Download data: TXT

(Submitter supplied) Soleus muscle from Eif6 heterozygous mice and wild-type mice profiled using Agilent gene expression arrays

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

8 Samples

Download data: TXT

(Submitter supplied) Tibialis anterior and gastrocnemius muscle from Eif6 heterozygous mice and wild-type mice profiled using Agilent gene expression arrays

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL25298

8 Samples

Download data: TXT

(Submitter supplied) Epidemiological studies reveal a strong link between low aerobic capacity and metabolic and cardiovascular diseases. Two-way artificial selection of rats based on low and high intrinsic exercise capacity has produced two strains that also differ in risk for metabolic syndrome (Koch LG, Britton SL. Artificial selection for intrinsic aerobic endurance running capacity in rats. Physiol Genomics 5:45-52, 2001). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3723

Platform:

GPL6101

24 Samples

Download data: TXT

Analysis of gastrocnemius muscle from strains of low and high inherited aerobic exercise capacity; these strains also differ in their risk for metabolic syndrome. Results provide insight into the link between oxygen metabolism and metabolic disease risk factors.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL6101

Series:

GSE17190

24 Samples

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(Submitter supplied) Evolutionary considerations suggest that the body has been optimized to perform at a high level in the fasted state when fatty acids and their ketone metabolites are a major fuel source for muscle cells. Because fasting is the most potent physiological stimulus for ketosis, we designed a study to determine the impact of intermittent fasting during endurance training on performance, and to elucidate the underlying cellular and molecular mechanisms. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

58 Samples

Download data: TXT

(Submitter supplied) Digital gene expression profiling was used to characterize the assembly of genes expressed in equine skeletal muscle and to identify the subset of genes that were differentially expressed following a ten month period of exercise training. The study cohort comprised 7 thoroughbred racehorses from a single training yard. Skeletal muscle biopsies were collected at rest from the gluteus medius at two time points: T1 (unconditioned), (9 +/- 0.5 months old) and T2 (conditioned) (20 +/- 0.7 months old). more...

Organism:

Equus caballus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL10300

13 Samples

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(Submitter supplied) Experiment designed to identify differences in gene expression patterns in previously sedentary individuals before an endurance exercise training program. This series compares 2 groups of individuals that display high and low insulin sensitivity (SI) response (HSIR and LSIR) after 20 weeks of exercise (a 4-fold difference in SI response). There were no differences before training for SI, sex, age, BMI or body fat in the individuals integrating the LSIR and HSIR groups. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2234

Platform:

GPL1412

6 Samples

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