GEO DataSets

(Submitter supplied) Rationale: Maternal immune responses can promote allergy development in offspring. Pilot data show that neonates of mother mice exposed during pregnancy to air pollution particles have increased allergic susceptibility. Objective: We investigated whether inflammatory response to titanium dioxide (TiO2) particles earlier considered immunologically ‘inert’ is enhanced during pregnancy. Methods: Pregnant BALB/c mice (or non-pregnant controls) received particle suspensions intranasally at day 14 of pregnancy. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2878

Platform:

GPL1261

16 Samples

Download data: CEL, CHP

Analysis of lungs from pregnant and non-pregnant BALB/c females following insufflation with inert titanium dioxide particles. Results provide insight into the mechanisms underlying the differences in response between pregnant and non-pregnant females to inhaled inert particles.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 development stage sets

Platform:

GPL1261

Series:

GSE7475

16 Samples

Download data: CEL, CHP

(Submitter supplied) Diesel exhaust (DE) has been shown to enhance allergic sensitization in animals following high dose instillation or chronic inhalation exposure scenarios. The purpose of this study was to determine if short term exposures to diluted DE enhance allergic immune responses to antigen, and identify possible mechanisms using microarray technology. BALB/c mice were exposed to filtered air or diluted DE to yield particle concentrations of 500 or 2000 µg/m3 4 hr/day on days 0-4. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

24 Samples

Download data: CEL, CHP, RPT

(Submitter supplied) Mouse BAL alveolar macrophages from pregnant E14 and control dams are compared to RAW cells cultured with estradiol to determine shared gene expression change patterns induced by pregnancy and estrogen

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

12 Samples

Download data: CEL

(Submitter supplied) The potential of diesel exhaust particles (DEP) to transform human bronchial epithelial cells (HBEC3) was investigated and a stably transformed cell line (T2-HBEC3) was established. Short-term DEP exposure experiments adds information of immunomodulatory effect markers and differences in susceptibility between normal and sensitized bronhial epithelial cells of the human lung.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

42 Samples

Download data: TXT

(Submitter supplied) Transcriptome of whole lung of rat from 3 genetic strains, 3 postnatal time points and 2 exposures (saline versus ovalbumin) in (mainly) 4 replicate measurements per condition.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

71 Samples

Download data: TXT

(Submitter supplied) Identify genes involved in regulation of inflammatory responses and gene-environemnt interactions, in macrophages from a set of mouse inbred strains termed the HMDP. The HMDP is a genetically diverse mapping panel comprised of classical inbred and recombinant inbred wild type mice. The RMA values of genes were used for genome wide association as described in Bennett et al Genome Research 2010.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8759

511 Samples

Download data: CEL

(Submitter supplied) Second-hand smoke (SHS) exposure during pregnancy has adverse effects on offspring. We used microarrays to characterize the gene expression changes caused by in-utero exposure and adult exposure to SHS in adult mouse lungs.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4609

Platform:

GPL1261

16 Samples

Download data: CEL

Analysis of lung from 15-wk-old males exposed in utero and then as adults to second hand smoke (SHS). These animals exhibit increased airway hyperresponsiveness. Results provide insight into the role of in utero SHS exposure in potentiating subsequent adult physiological responses to SHS exposure.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 4 protocol sets

Platform:

GPL1261

Series:

GSE36810

16 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:

GPL17021

16 Samples

Download data: COV

(Submitter supplied) Developmental exposure to particulate matter air pollution is harmful to cardiovascular health, but the mechanisms by which this exposure mediates susceptibility to heart disease is poorly understood. We have previously shown, in a mouse model, that gestational exposure to diesel exhaust results in increased cardiac hypertrophy, fibrosis and susceptibility to heart failure in the adult offspring following transverse aortic constriction. more...

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL17021

8 Samples

Download data: COV

(Submitter supplied) Developmental exposure to particulate matter air pollution is harmful to cardiovascular health, but the mechanisms by which this exposure mediates susceptibility to heart disease is poorly understood. We have previously shown, in a mouse model, that gestational exposure to diesel exhaust results in increased cardiac hypertrophy, fibrosis and susceptibility to heart failure in the adult offspring following transverse aortic constriction. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

8 Samples

Download data: TXT

(Submitter supplied) In utero exposure to diesel exhaust particulates has been associated with increased adult susceptibility to heart failure in mice but the mechanisms by which this exposure promotes susceptibility are poorly understood. To identify potential transcriptional effects that mediate this susceptibility, we have performed RNA-seq analysis on adult hearts from mice exposed to diesel exhaust in utero and that have subsequently undergone transverse aortic constriction. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18635

12 Samples

Download data: TXT

(Submitter supplied) Exposure to air particulate matter is associated with increased cardiovascular morbidity and mortality. One of the possible mechanisms is by promotion of atherosclerosis mediated by synergy of particulate matter chemicals and oxidized phospholipids on vascular endothelial cells. We treated human microvascular endothelial cells (HMEC) in triplicate wells with diesel exhaust particles (DEP) extract at a concentration of 5 and 25 mcg/ml, oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (ox-PAPC) at concentrations of 10, 20 and 40 mcg/ml or combination of DEP at 5 mcg/ml plus ox-PAPC at 10, 20 and 40 mcg/ml. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2889

Platform:

GPL2700

27 Samples

Download data: TXT

Analysis of microvascular endothelial cells treated at various concentrations of the model air pollutant diesel exhaust particles (DEP), an oxidized phospholipid (ox-PAPC), or both. Results provide insight into the synergistic effect of DEP and ox-PAPC in promoting vascular inflammation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent, 9 dose sets

Platform:

GPL2700

Series:

GSE6584

27 Samples

Download data: TXT

(Submitter supplied) Epidemiological studies have linked exposure to ambient particulate matter (PM) with increased asthmatic symptoms. Diesel exhaust particles (DEP) are a predominant source of vehicle derived ambient PM, and experimental studies have demonstrated that they may have adjuvant potential when given with an antigen. We previously compared 3 DEP samples: N-DEP, A-DEP, and C-DEP in a murine ovalbumin (OVA) mucosal sensitization model and reported the adjuvant activity to be: C-DEP ≈ A-DEP > N-DEP. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

24 Samples

Download data: CEL

(Submitter supplied) Genome-wide gene expression profiles in 5- and 10-days KDP20 exposure (n=8) compared to control (n=4) were performed for nasal inflammatory dysfunction induced by diesel particles, one of the notorious ambient pollutants.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30215

12 Samples

Download data: TXT