GEO DataSets

(Submitter supplied) Acute effects of different dietary fatty acids on the gene expression profiles of peripheral blood mononuclear cells in healthy young men. A randomized cross-over study. Gene expression profiles of peripheral blood mononuclear cells (PBMCs) have been used to reflect pathological and physiological states of humans. We theorized that these cells could also be used to show fatty acid specific gene expression profiles. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3704

Platform:

GPL7144

84 Samples

Download data: CEL

Analysis of peripheral blood mononuclear cells of individuals before and 6 hours after the consumption of shakes containing either mainly polyunsanturated (PUFA) or saturated fatty acids (SFA). Results provide insight into the molecular basis of the beneficial effect of PUFA on health.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent, 42 individual, 2 protocol sets

Platform:

GPL7144

Series:

GSE13466

84 Samples

Download data: CEL

(Submitter supplied) Early perturbations in vascular health can be detected by imposing subjects to a high fat (HF) challenge and measure response capacity. Subtle responses can be determined by assessment of whole-genome transcriptional changes. We aimed to magnify differences in health by comparing gene-expression changes in peripheral blood mononuclear cells (PBMCs) towards a high MUFA or SFA challenge between subjects with different cardiovascular disease risk profiles and to identify fatty-acid specific gene-expression pathways. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

128 Samples

Download data: CEL

(Submitter supplied) Fish oil supplementation is generally seen as beneficial for human health, due to the presence of n-3 polyunsaturated fatty acids (n-3 PUFAs). These fatty acids can elicit their effect through changes in gene expression. Effects of n-3 PUFAs on gene expression of inflammatory and atherogenic markers have been shown in several in vitro and animal studies. However, little evidence is available on human in vivo studies on n-3 PUFA related gene expression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL7144

96 Samples

Download data: CEL

(Submitter supplied) Dietary fat quality may influence skeletal muscle lipid handling and fat accumulation, thereby modulating insulin sensitivity. Objective: To examine acute effects of meals with various fatty acid (FA) compositions on skeletal muscle FA handling and postprandial insulin sensitivity in obese insulin resistant men. Design: In a single-blinded randomized crossover study, 10 insulin resistant men consumed three high-fat mixed-meals (2.6MJ). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4412

Platform:

GPL6244

56 Samples

Download data: CEL

Analysis of skeletal muscle (SM) from insulin resistant men 4 hrs after consumption of meals high in saturated FA (SFA), monounsaturated FA (MUFA), or polyunsaturated FA (PUFA). Results provide insight into mechanisms underlying effects of FA composition on SM FA handling and insulin sensitivity.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 10 individual, 3 protocol, 2 time sets

Platform:

GPL6244

Series:

GSE31901

56 Samples

Download data: CEL

(Submitter supplied) We investigated the effect of a saturated (SFA) and a monounsaturated (MUFA) rich diet on insulin sensitivity and adipose tissue gene expression profiles of subjects at risk for metabolic syndrome. A controlled-feeding trial was performed with 20 moderately overweight subjects. Subjects received a SFA-rich or a MUFA-rich diet for 8 weeks. Subcutaneous adipose tissue samples were obtained and insulin sensitivity was measured. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3678

Platform:

GPL7020

40 Samples

Download data: CEL

Analysis of adipose tissue from moderately overweight subjects who consumed a saturated fat (SFA)-rich diet for 2 weeks, followed by SFA or monounsaturated (MUFA)-rich intervention diets for 8 weeks. Results provide insight into role of dietary fat on the risk of developing metabolic syndrome.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 gender, 20 individual, 2 protocol, 2 time sets

Platform:

GPL7020

Series:

GSE14954

40 Samples

Download data: CEL

(Submitter supplied) Intake of high-fat foods raises postprandial plasma triglycerides and inflammatory markers, which may depend on the type of fat ingested. Dairy products are commonly consumed, but not much is known about the impact of milk fat and the milk fat globule membrane on postprandial inflammation. Here, we aimed to study the effect of milk fat with and without milk fat globule membrane and vegetable blend fat on post-prandial inflammation, with a focus on blood monocyte gene expression. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23227

107 Samples

Download data: RDATA, TXT