GEO DataSets

(Submitter supplied) Staphylococcus aureus is a highly adaptable human pathogen; therefore a constant search for new effective antibiotic compounds is being preformed. Gene expression profiling can be used to determine potential targets and mechanisms of action (MOA) of known or potential drugs. The goal of our study was a development of a focused transcriptome platform to be used for confirming the MOA of new chemical entities which are designed as inhibitors of Mur ligases. more...

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL1339

37 Samples

Download data: CEL, CHP

(Submitter supplied) The aim of the present study was to investigate the mechanisms by which fosfomycin restrains biofilm formation and affects a 24h-old biofilm of S. aureus. RNA sequencing (RNA-Seq) technology was used to compare the transcriptomes of S. aureus biofilms formed or treated with sublethal concentrations of fosfomycin.

Organism:

Staphylococcus aureus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19006

12 Samples

Download data: XLS

(Submitter supplied) Transcriptomic analysis of S. maltophilia D457 after one-hour induction with the antibiotic fosfomycin, the intermediate metabolites phosphoenolpyruvate or glyceraldehyde-3-phosphate

Organism:

Stenotrophomonas maltophilia

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30504

13 Samples

Download data: TXT

(Submitter supplied) Fosfomycin is a bactericidal antibiotic, analogous to phosphoenolpyruvate (PEP) that exerts its activity by inhibiting the activity of MurA. This enzyme catalyzes the first step of peptidoglycan biosynthesis, the transfer of enolpyruvate from PEP to uridine- diphosphate-N-acetylglucosamine. Fosfomycin is increasingly used in the last years, mainly for treating infections caused by Gram-negative multidrug resistant bacteria as Stenotrophomonas maltophilia, an opportunistic pathogen characterized by its low susceptibility to antibiotics of common use. more...

Organism:

Stenotrophomonas maltophilia

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25680

5 Samples

Download data: XLS

(Submitter supplied) In the present study, we employed Affymetrix Staphylococcus aureus GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Staphylococcus aureus to Ortho-Phenylphenol, which involved initial growth inhibition and metabolism. Keywords: Time course

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL1339

15 Samples

Download data: CEL

(Submitter supplied) Genome-wide transcriptional profiling studies of the growth of bacteria with antimicrobial agents often reveals aspects of the drug-specific protective bacterial response. Fusidic acid is a steroid antimicrobial that inhibits protein synthesis by interfering with the release of elongation factor G (EF-G) after it has functioned in the translocation step. Two hundred and seventy two genes were both up- and down-regulated in a fusidic acid-susceptible strain of Staphylococcus aureus following challenge with 2 mg/L-1 fusidic acid for 15 min. more...

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Platform:

GPL7072

4 Samples

Download data: TAV

(Submitter supplied) The lantibiotic mersacidin is an antimicrobial peptide of 20 amino acids that is ribosomally produced by Bacillus sp. strain HIL Y-85,54728. Mersacidin acts by complexing the sugar phosphate head group of the peptidoglycan precursor lipid II, thereby inhibiting the transglycosylation reaction of peptidoglycan biosynthesis. Here, we studied the transcriptomic response of S. aureus to subinhibitory concentrations of mersacidin using microarray and qRT-PCR techniques. more...

Organism:

Staphylococcus aureus; Staphylococcus aureus subsp. aureus N315

Type:

Expression profiling by array

Platforms:

GPL5429 GPL5421

14 Samples

Download data: GPR