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| Status |
Public on Jan 31, 2018 |
| Title |
Effects of fosfomycin on biofilm of a clinical Staphylococcus aureus isolated from osteoarticular infection by transcriptomal approach |
| Organism |
Staphylococcus aureus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The aim of the present study was to investigate the mechanisms by which fosfomycin restrains biofilm formation and affects a 24h-old biofilm of S. aureus. RNA sequencing (RNA-Seq) technology was used to compare the transcriptomes of S. aureus biofilms formed or treated with sublethal concentrations of fosfomycin.
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| Overall design |
Determination of the transcriptional profiling of S. aureus under 4 different experimental conditions. mRNA profiles were generated for bacteria under 4 hours-old biofilm formed with and without fosfomycin and 24 hours-old biofilm treated or not with fosfomycin for 24h, each in three biological replicates, by deep sequencing using Illumina HiSeq
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| Contributor(s) |
Marquès C, Collin V, Franceschi C, Chatellier S, Forestier C |
| Citation(s) |
31705133 |
| |
| Submission date |
Jun 13, 2016 |
| Last update date |
May 08, 2020 |
| Contact name |
Christiane Forestier |
| E-mail(s) |
[email protected]
|
| Organization name |
Laboratoire Microorganismes Génome et Enironnement
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| Department |
Université de Pharmacie
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| Street address |
28 Place Henri Dunant
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| City |
Clermont Ferrand |
| ZIP/Postal code |
63000 |
| Country |
France |
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| Platforms (1) |
| GPL19006 |
Illumina HiSeq 2500 (Staphylococcus aureus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA325459 |
| SRA |
SRP076463 |
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