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Links from GEO DataSets

Items: 20

1.

A Microarray approach for Identification of Candidate Genes Involved in Gyration of the Pig Cerebral Cortex

(Submitter supplied) In this study we examined brain gyration using the pig brain as model. Pig cortical tissue from two time points in development representing a non-folded, lissencephalic, brain (embryonic day 60) and primary-folded, gyrencephalic, brain (embryonic day 80) were examined by whole genome expression microarray studies.
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL3533
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE18467
ID:
200018467
2.

Expression profiling of motor cortex in sporadic amyotrophic lateral sclerosis

(Submitter supplied) We used oligonucleotide microarrays to find differentially expressed genes between control subjects and those affected by sporadic amyotrophic lateral sclerosis. Keywords: disease state analysis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL1708
20 Samples
Download data
Series
Accession:
GSE4595
ID:
200004595
3.

Sharp changes in gene expression levels along germinal layers distinguish the development of gyrencephaly

(Submitter supplied) Gyrencephalic species develop folds in the cerebral cortex in a stereotypic manner, but the genetic mechanisms underlying this unique patterning process are unknown. We present a large-scale transcriptomic analysis of individual germinal layers in the developing cortex of the gyrencephalic ferret, comparing between regions prospective of fold and fissure. We find unique transcriptional signatures in each germinal compartment, indicating that thousands of genes are differentially expressed between regions, including ~80% of genes mutated in human cortical malformations. more...
Organism:
Mustela putorius furo
Type:
Expression profiling by array
Platform:
GPL19111
19 Samples
Download data: TXT
Series
Accession:
GSE60687
ID:
200060687
4.

Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures.

(Submitter supplied) Transcriptome profile of whole tissue and cultured neuronal cells from the hippocampus and cortex from pooled littermate embryos (at 17-18 days post conception) of 2 mouse genotypes C57BL/6 congenic WT and Fmr1 KO.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
42 Samples
Download data: CEL
Series
Accession:
GSE71034
ID:
200071034
5.

Gene expression of bovine embryo

(Submitter supplied) The objective of the present study was to use our own fabricated bovine embryo cDNA microarray to profile genome-wide expression patterns of genes during the implantation period. Duplicate readings were obtained by hybridization of a Cy3/Cy5 probe mixture for each sample. Data normalization was performed the local background intensity of each array spot was smoothed by the local weight regression (lowess) smoother and subtracted from spot intensity data. more...
Organism:
Bos taurus
Type:
Expression profiling by array
Dataset:
GDS1003
Platform:
GPL1221
11 Samples
Download data: TIFF
Series
Accession:
GSE1414
ID:
200001414
6.
Full record GDS1003

Embryogenesis and early fetal development: time course

Expression profiling of embryos at various days of gestation up to 21 days and fetuses and fetal membranes at 27 and 28 days of gestation. Results provide insight into the regulation of embryonic, fetal, and fetal membrane differentiation.
Organism:
Bos taurus
Type:
Expression profiling by array, count, 7 development stage, 3 tissue sets
Platform:
GPL1221
Series:
GSE1414
11 Samples
Download data: TIFF
7.

Transcriptome changes at the initiation of elongation in the bovine conceptus

(Submitter supplied) Temporal changes in the embryo transcriptome between the blastocyst stage (Day 7) and initiation of elongation (Day 13) differ between in vivo- and in vitro-derived embryos and are reflective of subsequent developmental fate. The aim of this study was to examine the temporal changes in transcriptional profile as the embryo develops from a spherical blastocyst on Day 7 to an ovoid conceptus at the initiation of elongation on Day 13 and to highlight differences in these temporal gene expression dynamics between in vivo- and in vitro-derived blastocysts which may be associated with embryonic survival/mortality using the bovine Affymetrix microarray.
Organism:
Bos taurus
Type:
Expression profiling by array
Platform:
GPL2112
12 Samples
Download data: CEL
Series
Accession:
GSE27817
ID:
200027817
8.

Coordination of neuron production in mouse and human cerebral cortex by the homolog of Drosophila Mastermind protein

(Submitter supplied) The coordination of progenitor self-renewal, neuronal production and migration is essential to the normal development and evolution of the cerebral cortex. Numerous studies have shown that the Notch, Wnt/beta-catenin and Neurogenin pathways contribute separately to progenitor expansion, neurogenesis, and neuronal migration, but it is unknown how these signals are coordinated. In vitro studies suggested that the mastermind-like 1 (MAML1) gene, homologue of the Drosophila Mastermind, plays a role in coordinating the afore-mentioned signaling pathways, yet its role during cortical development remains largely unknown. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL11154
37 Samples
Download data: RPKM
Series
Accession:
GSE76491
ID:
200076491
9.

Dynamics of the transcriptional landscape during human gonad development during fetal life

(Submitter supplied) Fetal life is a crucial period for sexual reproduction when bipotential gonads differentiate into either a testis or an ovary. Gaining insights into the complex molecular events underlying this process is central to a better understanding of disorders of sexual development. The present work therefore intends to improve the knowledge on molecular pathways at play during gonad development in humans using RNA-Sequencing.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
48 Samples
Download data: BED, GTF, TXT, XLSX
Series
Accession:
GSE116278
ID:
200116278
10.

Expression profiling in cortical GABAergic neurons at neonate

(Submitter supplied) During embryonic development, GABAergic interneurons, a main inhibitory component in the cerebral cortex, migrate tangentially from the ganglionic eminence (GE) to cerebral cortex. After reaching the cerebral cortex, they start to extend their neurites for constructing local neuronal circuits around the neonatal stage. Aberrations in migration or neurite outgrowth are implicated in neurological and psychiatric disorders such as epilepsy, schizophrenia and autism. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2995
8 Samples
Download data: TXT
Series
Accession:
GSE93295
ID:
200093295
11.

Expression profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls

(Submitter supplied) Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex and orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
82 Samples
Download data: CEL
Series
Accession:
GSE5392
ID:
200005392
12.

Adult postmortem brain tissue (orbitofrontal cortex) from subjects with bipolar disorder and healthy controls

(Submitter supplied) Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. Orbitofrontal cortex tissue from a cohort of 30 subjects was investigated and the final analysis included 10 bipolar and 11 control subjects. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2191
Platform:
GPL96
21 Samples
Download data: CEL
Series
Accession:
GSE5389
ID:
200005389
13.

Adult postmortem brain tissue (dorsolateral prefrontal cortex) from subjects with bipolar disorder and healthy controls

(Submitter supplied) Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex) from patients with bipolar disorder and matched healthy controls. A cohort of 70 subjects was investigated and the final analysis included 30 bipolar and 31 control subjects. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2190
Platform:
GPL96
61 Samples
Download data: CEL
Series
Accession:
GSE5388
ID:
200005388
14.
Full record GDS2191

Bipolar disorder: orbitofrontal cortex

Analysis of postmortem orbitofrontal cortex from 10 adults with bipolar disorder. Results provide insight into the pathophysiology of the disease.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL96
Series:
GSE5389
21 Samples
Download data: CEL
DataSet
Accession:
GDS2191
ID:
2191
15.
Full record GDS2190

Bipolar disorder: dorsolateral prefrontal cortex

Analysis of postmortem dorsolateral prefrontal cortex from 30 adults with bipolar disorder. Results provide insight into the pathophysiology of the disease.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL96
Series:
GSE5388
61 Samples
Download data: CEL
DataSet
Accession:
GDS2190
ID:
2190
16.

Gene expression analysis of the developing cortex

(Submitter supplied) The mammalian neocortex develops layer organizations with regional differences represented by expression of multiple genes at embryonic stages. These genes could play important roles in the formation of areal cyto-architecture, yet, the number of genes identified so far is not sufficient to explain such intricate processes. Here we collected five regions; the medial, dorsal, lateral, rostral, and occipital, from the dissected E16.5 mouse cerebral cortex and performed extensive gene expression analysis using the Affymetrix U74Av2 array. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS615
Platform:
GPL81
12 Samples
Download data
Series
Accession:
GSE929
ID:
200000929
17.
Full record GDS615

Cerebral cortex regional expression

Analysis of medial, dorsal, lateral, rostral, and occipital regions from strain ICR embryo day 16.5 cerebral cortex provides insight into molecular mechanisms of neocortical area and layer formation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 6 tissue sets
Platform:
GPL81
Series:
GSE929
12 Samples
Download data
DataSet
Accession:
GDS615
ID:
615
18.

Identification of Candidate Genes for Alcohol Preference by Expression Profiling of Congenic Strains

(Submitter supplied) A highly significant quantitative trait locus (QTL) that influenced alcohol preference was identified in the iP/iNP rats on chromosome 4. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared to the iNP background strain. This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
60 Samples
Download data: CEL
Series
Accession:
GSE5849
ID:
200005849
19.

Expression data from non-infected and Salmonella Choleraesuis infected mesenteric lymph nodes

(Submitter supplied) To understand the host transcriptional response to S. enterica serovar Choleraesuis (S. Choleraesuis), the first generation Affymetrix porcine GeneChip® was used to identify differentially expressed genes in the mesenteric lymph nodes responding to infection at acute (8 hours (h), 24h, 48h post-inoculation (pi)) and chronic stages (21 days (d) pi) The objectives of this study were to identify and examine the stereotypical gene expression response within the host mesenteric lymph nodes to S. more...
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL3533
15 Samples
Download data: CEL, EXP
Series
Accession:
GSE7314
ID:
200007314
20.

Expression data from longissimus dorsi muscle of Shaziling pig at 25-days old and longissimus dorsi musle of Yorkshire pig at 25-days old

(Submitter supplied) To characterize the mechanism of porcine skeletal muscle development, transcriptome analysis of longissimus dorsi muscle between Shaziling and Yorkshire pig breeds
Organism:
Sus scrofa
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19176
2 Samples
Download data: FA, TXT
Series
Accession:
GSE70673
ID:
200070673
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