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| Status |
Public on Jul 27, 2006 |
| Title |
Adult postmortem brain tissue (orbitofrontal cortex) from subjects with bipolar disorder and healthy controls |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. Orbitofrontal cortex tissue from a cohort of 30 subjects was investigated and the final analysis included 10 bipolar and 11 control subjects. Differences between disease and control groups were identified using a rigorous statistical analysis with correction for confounding variables and multiple testing.
Keywords: disease state analysis
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| Overall design |
RNA extracted from human postmortem brain tissue from adult subjects with bipolar disorder and healthy controls was hybridised to Affymetrix HG-U133A GeneChips to identify differentially expressed genes in the disease state.
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| Contributor(s) |
Bahn S, Ryan MM, Lockstone HE, Huffaker SJ, Wayland MT, Webster MJ |
| Citation(s) |
16894394 |
| |
| Submission date |
Jul 25, 2006 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Sabine Bahn |
| E-mail(s) |
[email protected]
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| Organization name |
University of Cambridge
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| Lab |
Cambridge Centre for Neuropsychiatric Research
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| Street address |
Tennis Court Road
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| City |
Cambridge |
| ZIP/Postal code |
CB2 1QT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (21)
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| This SubSeries is part of SuperSeries: |
| GSE5392 |
Expression profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls |
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| Relations |
| BioProject |
PRJNA104327 |
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