GEO DataSets

(Submitter supplied) A/J mice are genetically predisposed to spontaneous and/or chemically-induced lung tumors while C57BL/6J (B6) mice are resistant. This genetic disparity provides a unique scenario to identify molecular mechanisms associated with the lung response to welding fume at the transcriptome level.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6103

48 Samples

Download data: TXT

(Submitter supplied) This study utilized microarray technology as an exploratory search for mechanisms of systemic effects after welding fume inhalation. In addition, the applicability of this methodological approach for determining specific exposure-induced responses was examined.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

47 Samples

Download data: TXT

(Submitter supplied) Exposure to welding fume consists of a mixed exposure of metal-rich particulate matter with gases (ozone, carbon monoxide) and/or vapors (VOCs). Data suggests that welders are immune compromised. Given the inability of pulmonary leukocytes to properly respond to a secondary infection, the question arose concerning how far upstream the dysfunction persisted. Our aim was to evaluate circulating leukocyte functionality after welding fume exposure. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

48 Samples

Download data: TXT

(Submitter supplied) Previous studies have reported sex differences in the incidence, prognosis and control of respiratory diseases and lung immunity. However, the role of sex hormones in the inflammatory response, and the mechanisms involved are unknown. Here, we explored whether variations in circulating hormone levels in the mouse estrous cycle could alter the inflammatory response to air pollutants such as ozone. To test this, female mice of the C57BL/6 background were exposed to 2ppm of ozone or filtered air (control) for 3 hours at different stages of the estrous cycle. more...

Organism:

Mus musculus

Type:

Expression profiling by RT-PCR

Platform:

GPL25881

34 Samples

Download data: TXT

(Submitter supplied) Patients with inflammatory lung diseases are often additionally exposed to polycyclic aromatic hydrocarbons like B[a]P and B[a]P-induced alterations in gene expression in these patients may contribute to the development of lung cancer. Mice were intra-nasally treated with lipopolysaccharide (LPS, 20 μg/mouse) to induce pulmonary inflammation and subsequently exposed to B[a]P (0.5 mg/mouse) by intratracheal instillation We used RNA microarrays to detail the global gene expression change after each treatment. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20837

15 Samples

Download data: CEL

(Submitter supplied) Exposure to high levels of arsenic in drinking water is associated with several types of cancers including lung, bladder and skin, as well as vascular disease and diabetes. Drinking water standards are based primarily on epidemiology and extrapolation from higher dose experiments, rather than measurements of phenotypic changes associated with chronic exposure to levels of arsenic similar to the current standard of 10ppb, and little is known about the difference between arsenic in food as opposed to arsenic in water. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3801

Platform:

GPL1261

55 Samples

Download data: CEL, CHP

Analysis of lungs of C57BL/6 males, on defined diets, chronically exposed to environmentally relevant concentrations of arsenic (As) in food or drinking water. Acute exposure to As through intraperitoneal injection also examined. Results provide insight into the basis of As toxicity from ingestion.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 5 agent, 4 dose, 2 growth protocol, 4 protocol sets

Platform:

GPL1261

Series:

GSE11056

55 Samples

Download data: CEL, CHP

(Submitter supplied) The adult human lung has a very limited capacity to regenerate functional alveoli. In contrast, adult mice have a remarkable capacity for neoalveolarization following either lung resection or injury. The molecular basis for this unique capability to regenerate lung tissue in mice is largely unknown. We examined the transcriptomic responses to single lung pneumonectomy in adult mice in order to elucidate prospective molecular signaling used in this species during lung regeneration. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

8 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling in C57BL/6J and A/J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background Comparison of whole genome expression data of amygdala and hippocampus of both C57BL/6J and A/J mouse inbred strains using a network approach

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6103

35 Samples

Download data: TXT

(Submitter supplied) We have reported previously that when chromosome Y (chrY) from the mouse strain C57BL/6J (abbreviated as B) was substituted for that of A/J mice (ChrY<A>), cardiomyocytes from the resulting 'chromosome substitution' C57BL/6J-chrY<A> strain (abbreviated as B.Y) were smaller than that of their C57BL/6J counterparts. In reverse, when chrY<A> from A/J mice was substituted for that of chrY<B>, cardiomyocytes from the resulting A/J-chrY<C57> strain were larger than in their A/J counterparts. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

16 Samples

Download data: TXT

(Submitter supplied) In this study, time dependent genome wide lung mRNA profiling changes were assessed using C57BL/6J and A/J mice. Through comprehensive bioinformatics and functional genomics analyses, we identified both temporal and strain dependent gene expression patterns, systemically mapped key regulators, bioprocesses, and transcriptional networks controlling lung maturation, providing the basis for new therapeutic strategies to enhance lung function in preterm infants. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

37 Samples

Download data: CEL

(Submitter supplied) Background: Lung cancer is a multistage process with poor prognosis and high morbidity. Importantly, the genetics of dysplasia, a facultative cancer, at the edge of malignant transformation is unknown. Results: We employed laser microdissection to harvest dysplastic as opposed to transgenic but otherwise morphologically unaltered epithelium and compared findings to non-transgenic lung. We then employed microarrays to search genome wide for gene regulatory networks. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3825

Platform:

GPL1261

15 Samples

Download data: CEL, CHP

Analysis of dysplastic lung cells and transgenic but morphologically unaltered lung cells, both harvested from SP-C/c-raf transgenics. Normal lung from non-transgenic littermates also examined. Results provide insight into molecular mechanisms underlying an early stage of lung cancer development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 3 disease state, 2 gender, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE13963

15 Samples

Download data: CEL, CHP

(Submitter supplied) To better understand the temporal dynamics of gene expression during normal murine lung development we characterized global gene expression at 26 time points in three common inbred strains of mice (A/J, C57BL/6J, and C3H/HeJ). The data set provides a unique resource for identifying patterns of gene expression changes during normal lung development and for investigating the developmental origins of respiratory disease. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20894

216 Samples

Download data: CEL, TSV, TXT