GEO DataSets

(Submitter supplied) We report for the first time that secretoglobin (SCGB) 3A2, a novel cytokine-like molecule, predominantly expressed in pulmonary airways epithelium, drastically reduced the severity of lung fibrosis using bleomycin-induced mouse model.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4200

16 Samples

Download data: GPR

(Submitter supplied) Secretoglobin (SCGB) 3A2 is a cytokine-like secretory protein and is predominantly expressed in airway epithelial cells. While SCGB3A2 is known to have anti-inflammatory, growth factor, and anti-fibrotic activities, its roles in lung homeostasis and diseases are still elusive. In order to obtain an insight into these roles, a transgenic mouse line over-expressing SCGB3A2 in the lung using the human surfactant protein-C promoter was established.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

8 Samples

Download data: TXT

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease characterized by enhanced fibroblast proliferation, collagen synthesis, extracellular matrix deposition. We obtained 28 IPF patient lung tissue samples from the Lung Tissue Research Consortium (LTRC). Here we determined the miRNA expression profiles in these IPF lung samples.

Organism:

Homo sapiens; Mus musculus; Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL26371

29 Samples

Download data: GPR

(Submitter supplied) Secretoglobin (SCGB) 3A2 was originally identified as a downstream target in lung for the homeodomain transcription factor NKX2-1, whose null mutation resulted in severely hypoplastic lungs. A very low level of SCGB3A2 is expressed in lungs at embryonic day (E) 11.5 during mouse development, which markedly increases by E16.5, the time when lung undergoes dramatic morphological changes. These results suggest that SCGB3A2 may be involved in lung development. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6525

4 Samples

Download data: GPR

(Submitter supplied) Genomic profiling of RNA from cultured human fibroblasts of donor samples in the 10-14th passage was carried out to determine expression changes in the fibroblasts of individual with different degrees of pulmonary fibrosis. Donors consisted of individuals with rapid progressing pulmonary fibrosis, slow progressing pulmonary fibrosis, or no fibrosis.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4580

Platform:

GPL570

14 Samples

Download data: CEL

(Submitter supplied) Genomic profiling of bleomycin- and saline-treated mice across 7 timepoints (1, 2, 7, 14, 21, 28, 35 days post treatment) was carried out in C57BL6/J mice to determine the phases of response to bleomycin treatment which correspond to onset of active pulmonary fibrosis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

111 Samples

Download data: CEL

Analysis of lung fibroblasts from individuals with rapid or slow progressing idiopathic pulmonary fibrosis (IPF). Results provide insight into molecular mechanisms underlying the different degrees of

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state sets

Platform:

GPL570

Series:

GSE44723

14 Samples

Download data: CEL

(Submitter supplied) We purposed to examine the effect of PGF receptor FP in development of bleomycin-induced pulmonary fibrosis in mice. We performed gene expression analysis in the lung of WT and FP-KO mice on Days 0, 7 and 14. We found out that fibrosis-related genes such as various isoforms of collagen, which were induced on Day 7 and continued to increase or remained unchanged on Day 14, were induced to less extent in FP-KO mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

25 Samples

Download data: CEL

(Submitter supplied) Gene expression in lung tissues were evallulated in SCGB3A2 knock-out mice.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

7 Samples

Download data: CSV

(Submitter supplied) The wild type (WT) and TLR4 -/- pulmonary fibroblasts were treated with phosphate-buffered saline (PBS), 1 µg/mL recombinant mouse (rm) CIRP, 2 ng/mL rmTGF-ß1 (R&D Systems), or rmCIRP plus rmTGF-ß1. The cell lysates collected at 24 hours were used for high throughput mRNA sequencing.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

24 Samples

Download data: TXT