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| Status |
Public on Apr 30, 2011 |
| Title |
SCGB3A2 suppresses bleomycin-induced pulmonary fibrosis through activation of STAT1 and up-regulation of SMAD7　 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We report for the first time that secretoglobin (SCGB) 3A2, a novel cytokine-like molecule, predominantly expressed in pulmonary airways epithelium, drastically reduced the severity of lung fibrosis using bleomycin-induced mouse model.
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| Overall design |
DNA microarrays were performed using RNAs isolated from mouse lungs in two experiments. In the first experiments, mice were adminitered intravenously SCGB3A2 or PBS once daily for a week, starting on day 14 after BLM administration, and in the second experiments, SCGB3A2 or PBS was administered intravenously for 12 hrs.
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| Contributor(s) |
Kimura S, Kurotani R |
| Citation(s) |
21478551 |
| |
| Submission date |
Apr 28, 2010 |
| Last update date |
May 25, 2012 |
| Contact name |
Reiko Kurotani |
| E-mail(s) |
[email protected]
|
| Phone |
+81-45-787-2575
|
| Fax |
+81-45-788-1470
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| URL |
http://www.yokohama-cu.ac.jp/
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| Organization name |
Yokohama City University School of Medicine
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| Lab |
Cardiovascular　Research Institute
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| Street address |
3-9,fukuura,kanazawa-ku
|
| City |
Yokohama |
| State/province |
Kanagawa |
| ZIP/Postal code |
236-0004 |
| Country |
Japan |
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| Platforms (1) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA126181 |
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