Similar studies for GEO DataSets (Select 200025771) - GEO DataSets

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Items: 20

Select item 2000257711.

High-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)

(Submitter supplied) Neuroblastoma (NB) is an aggressive tumor that affects both infants and children. The disease outcome is greatly influenced by age of patient, stage, chromosome copy number aberrations (CNAs) and gene expression abnormalities. We analyzed, by microarray technology, genome and transcriptome of 3 groups of tumors of patients with metastatic disease: G1, stage 4S and MYCN single copy; G2, stage 4 younger than 18 months of age, MYCN single copy with no disease progression and G3, stage 4, older than 19 months, with unfavorable outcome. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by array

4 related Platforms
133 Samples

Download data: TXT

Series

Accession:: GSE25771

ID:: 200025771

Select item 2000561092.

Chromosome 17/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma

(Submitter supplied) Oligonucleotide aCGH profiles from 37 neuroblastoma tumor samples were generated using 44K or 105K microarrays.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platforms:: GPL4093 GPL2873 GPL2879
37 Samples

Download data: TXT

Series

Accession:: GSE56109

ID:: 200056109

Select item 2000454803.

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome variation profiling by array; Expression profiling by array

6 related Platforms
881 Samples

Download data: TXT

Series

Accession:: GSE45480

ID:: 200045480

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000359514.

miRNA Expression Profiling in Ovarian Cell Lines compared to pooled commercial RNA samples

(Submitter supplied) We investigated whether levels of serum microRNAs (miRNAs) could discriminate women with high-grade serous ovarian epithelial cancer (SEOC) from age matched healthy volunteers. miRNA expression profiling was performed on 4 SEOC cell lines and normal human ovarian surface epithelial cells (HOSE). miR-182, miR-200a, b and c were highly overexpressed in the SEOC cell lines. miR-103, miR-92a and miR-638 displayed relatively invariant expression and with RNU48, were assessed, as putative serum miRNA normalizers. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL15257
5 Samples

Download data: GAL, SPOT

Series

Accession:: GSE35951

ID:: 200035951

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000034725.

Sanger/Nimblegen Human array painting array_Case 1

(Submitter supplied) Breakpoint spanning oligonucleotide arrays were designed essentially as described previously (Selzer et al., 2005). Briefly, the regions of interest were repeat-masked. The array design contained both 50-mer fixed length probes and isothermal probes that ranged in length from 45 bp to 77 bp. Probes were generated from both strands, and replicated on the array 3 times. The arrays were constructed by maskless array synthesis technology (NimbleGen Systems Inc.), with up to 385,000 oligonucleotides being synthesized by photolithography. more...

Organism:: Homo sapiens

1 Series
1 Sample

Download data

Platform

Accession:: GPL3472

ID:: 100003472

PubMed Similar studies

Select item 2000359536.

High-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)

(Submitter supplied) Less than 30% of children with high-risk (HR) metastatic neuroblastoma (NB) show a long survival (Pearson 2000). In order to identify novel molecular prognostic markers useful to better predict patients’ relapse risk estimation, we performed genome- and/or transcriptome-wide analyses of 129 stage 4 HR-NBs. This is the largest study for this NB subtype. Children older than 1 year of age at diagnosis were categorized as “short-survivors” (dead of disease within 5 years from diagnosis) and “long-survivors” (alive with an overall survival time > 5 years). more...

Organism:: Homo sapiens

Type:: Genome variation profiling by array

Platforms:: GPL2873 GPL5477
35 Samples

Download data: TXT

Series

Accession:: GSE35953

ID:: 200035953

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000131417.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by SNP array; SNP genotyping by SNP array

Platforms:: GPL2004 GPL570
53 Samples

Download data: CEL

Series

Accession:: GSE13141

ID:: 200013141

Select item 2000131378.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: SNP data

(Submitter supplied) Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations. Genomic copy number losses and gains had been delineated in the tumours using FISH and SNP arrays. We have identified genes significantly altered by 7 recurrent alterations: 1p, 3p, 4p, 10q and 11q loss, 2p and 17q gain, and genes co-amplified and over-expressed as a result of MYCN amplification. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:: GPL2004
23 Samples

Download data: CEL

Series

Accession:: GSE13137

ID:: 200013137

PubMed Similar studies

Select item 2000131369.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: expression data

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
30 Samples

Download data: CEL

Series

Accession:: GSE13136

ID:: 200013136

Select item 20000578410.

Array-based comparative genomic hybridization analysis of primary neuroblastoma

(Submitter supplied) We conducted microarray-based comparative genomic hybridization (array-CGH) with a DNA chip carrying 2,464 BAC clones to examine genomic aberrations of 236 neuroblastomas (112 sporadic and 124 mass screening-detected). In paralell, gene-expression profiling was also performed by using in-house cDNA microarrays. Keywords: Comparative genomic hybridization

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL4242
236 Samples

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Series

Accession:: GSE5784

ID:: 200005784

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001814411.

Array-based gene expression, CGH and tissue data define a 12q24 gain in neuroblastic tumors with prognostic implication

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL570 GPL9202
5 Samples

Download data: CEL, TXT

Series

Accession:: GSE18144

ID:: 200018144

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001814312.

aCGH of neuroblastic tumors

(Submitter supplied) Title: Array-based gene expression, CGH and tissue data define a 12q24 gain in neuroblastic tumors with prognostic implication. Background: Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a few clinically useful prognostic markers have been found. Here, we present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for neuroblastoma. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL9202
2 Samples

Download data: TXT

Series

Accession:: GSE18143

ID:: 200018143

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001813913.

Array-based gene expression in neuroblastic tumors

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
3 Samples

Download data: CEL

Series

Accession:: GSE18139

ID:: 200018139

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007353714.

TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors

(Submitter supplied) Whole genome sequencing detected structural rearrangements of TERT in 17/75 high stage neuroblastoma with 5 cases resulting from chromothripsis. Rearrangements were associated with increased TERT expression and targeted immediate up- and down-stream regions of TERT, placing in 7 cases a super-enhancer close to the breakpoints. TERT rearrangements (23%), ATRX deletions (11%) and MYCN amplifications (37%) identify three almost non-overlapping groups of high stage neuroblastoma, each associated with very poor prognosis

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
34 Samples

Download data: CEL

Series

Accession:: GSE73537

ID:: 200073537

Select item 20015609215.

FOXR2 stabilizes MYCN protein and identifies non-MYCN-amplified neuroblastoma patients with unfavorable outcome

(Submitter supplied) The stabilization of MYCN by FOXR2 represents an alternative mechanism to MYCN amplification to increase MYCN protein levels. As such, FOXR2 expression identifies another subset of neuroblastoma patients with unfavorable clinical outcome. Background: Clinical outcomes of neuroblastoma patients range from spontaneous tumor regression to fatality. Hence, understanding the mechanisms that cause tumor progression are crucial for the treatment of patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE156092

ID:: 200156092

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001771416.

11 Neuroblastoma cell lines under normoxic and hypoxic conditions

(Submitter supplied) Hypoxia is a low oxygen condition that occurs in the developing tumor mass and that is associated with poor prognosis and resistance to chemo- and radio-therapy. The definition of the hypoxia gene signature is fundamental for the understanding of tumor biology, as in the case of neuroblastoma, the most common pediatric solid tumor. The issue of identifying a significant group of variables in microarray gene expression experiments is particularly difficult due to the typical high dimensional nature of the data and great effort has been spent in the development of feature selection techniques. more...