GEO DataSets

(Submitter supplied) Oral squamous cell carcinoma (OSCC) is a lethal disease and early death usually occurs as a result of local invasion and regional lymph node metastases. We used microarrays to identify down or upregulated genes in OSCCs compared with non-malignant controls.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4560

Platforms:

GPL96 GPL570

11 Samples

Download data: CEL, CHP

Analysis of oral squamous cell carcinoma (OSCC)-derived cell lines. OSCC is a lethal disease with early death typically occurring as a result of local invasion and regional lymph node metastases. Results provide insight the molecular mechanisms underlying OSCC.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 9 cell line sets

Platform:

GPL96

Series:

GSE31853

9 Samples

Download data: CEL, CHP

(Submitter supplied) There are limited studies attempting to correlate the expression changes in oral squamous cell carcinoma with clinically relevant variables. We determined the gene expression profile of 16 tumor and 4 normal tissues from 16 patients by means of Affymetrix Hu133A GeneChips. The hybridized RNA was isolated from cells obtained with laser capture microdissection, then was amplified and labeled using T7 polymerase-based in vitro transcription. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1584

Platform:

GPL96

20 Samples

Download data: CEL

Analysis of oral squamous cell carcinoma (OSCC) cells from 16 patients. OSCC cells isolated from tumors by laser capture microdissection. Results identify a strong correlation between gene expression profile and tumor invasiveness in OSCC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 9 other sets

Platform:

GPL96

Series:

GSE3524

20 Samples

Download data: CEL

(Submitter supplied) Metastasis via the lymphatics is a major risk factor in squamous cell carcinoma of the oral cavity (OSCC). We sought to determine whether the presence of metastasis in the regional lymph node could be predicted by a gene expression signature of the primary tumor. A total of 18 OSCCs were characterized for gene expression by hybridizing RNA to Affymetrix U133A gene chips. Genes with differential expression were identified using a permutation technique and verified by quantitative RT-PCR and immunohistochemistry. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1062

Platform:

GPL96

27 Samples

Download data: CEL

Expression profiling of 18 primary squamous cell carcinomas of the oral cavity with or without lymph node metastasis. Expression in lymph node metastasis also examined. Results used to identify gene expression signature in primary tumors that indicates the presence of lymph node metastasis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 tissue sets

Platform:

GPL96

Series:

GSE2280

27 Samples

Download data: CEL

(Submitter supplied) To examine the role of hepatpcyte growth factor activator inhibitor type 1 (HAI-1) in cancer, we analyzed effect of HAI-1 silencing on gene expression profiles of human oral squamous cell carcinoma cell line, SAS. We used short hairpin RNA (shRNA) directed against HAI-1 mRNA. We constructed retroviral vectors which showed stable and significant silencing effects on HAI-1 genes of SAS. Microarray data of the expression profiles of duplicated experiments of HAI-1-knockdown SAS with that from the control cell are shown.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

4 Samples

Download data: CEL, TXT

(Submitter supplied) The orthotopic transplantation of human OEC-M1 cells in immune-compromised mice was established to feasibly study tumorigenesis and lymph node metastasis of OSCC. Through in vivo selection, two sublines, designated as LN1-1 and LN1-2 were successfully isolated from cervical lymph nodes and identified to originate from OEC-M1 cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

3 Samples

Download data: TXT

(Submitter supplied) p63, a homologue of the tumor suppressor p53, is critical for the development and maintenance of squamous epithelia. p63 is specifically expressed in the basal layers of stratified epithelial tissues, and is considered to be a specific marker for cells of this type. The role of p63 in tumorigenesis remains poorly defined. Numerous studies have highlighted the oncogenic potential of the predominant p63 isoform, ΔNp63α; however, data suggests that other p63 proteins can act as tumor suppressors or alter the metastatic potential of tumors. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2086 GDS2087 GDS2088

Platforms:

GPL96 GPL97 GPL570

14 Samples

Download data

Analysis of squamous cell lines following siRNA knockdown of the transcription factor p63, a homolog of the tumor suppressor p53. p63 encodes multiple isoforms that activate or repress transcription, and is critical for the development and maintenance of squamous epithelia.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 cell line, 2 cell type, 2 protocol sets

Platform:

GPL570

Series:

GSE4975

6 Samples

Download data

Analysis of squamous cells following siRNA knockdown of the transcription factor p63, a homolog of the tumor suppressor p53. p63 encodes multiple isoforms that activate or repress transcription, and is critical for the development and maintenance of squamous epithelia.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell line, 2 cell type, 2 protocol sets

Platform:

GPL97

Series:

GSE4975

4 Samples

Download data

Analysis of squamous cells following siRNA knockdown of the transcription factor p63, a homolog of the tumor suppressor p53. p63 encodes multiple isoforms that activate or repress transcription, and is critical for the development and maintenance of squamous epithelia.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell line, 2 cell type, 2 protocol sets

Platform:

GPL96

Series:

GSE4975

4 Samples

Download data

(Submitter supplied) To uncover the oncogenic pathways of nasopharyngeal carcinoma, gene expression profiles of primary NPC cell strains and NPC-derived cell lines were conducted and analyzed in depth. Keywords: Oncogenesis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8018

14 Samples

Download data: TXT

(Submitter supplied) To genome-wide screening for the genes whose expression are responsible for the promoter DNA methylation, we performed the cDNA microarray with oral cancer cells before and after a DNA methyltransferase inhibitor, 5-aza-2’-deoxycytidine (AzC), treatment.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5625

Platform:

GPL6883

16 Samples

Download data: TXT

(Submitter supplied) According to epidemiological studies, a vast majority, approximately 80%~90% of male OSCC patients in Taiwan habitually drink alcohol (A), and chew betel quid (B), and use cigarette (C). To assess the impact of these dietary factors on the transcriptom, we conduct a high-throughput screen survey in an oral cancer cohort with exposure of A, B, and C. Results indicate several potential oncogenes and tumor suppressor genes are dysregulated in OSCC patients with ABC risk factors.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6883

80 Samples

Download data: TXT

Analysis of oral squamous cell carcinoma (OSCC) cell lines: OC3, SAS, SCC-15, and HSC3, treated with 5-aza-2’-deoxycytidine (AzC), an inhibitor of DNA methyltransferase. Results provide insight into potential tumor suppressor genes silenced by DNA hypermethylation in OSCC.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 4 cell line sets

Platform:

GPL6883

Series:

GSE38823

16 Samples

Download data

(Submitter supplied) The human nm23-H1 was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low versus high metastatic potential. It encodes for one of two subunits of the nucleoside-diphosphate kinase. Besides its role in the maintenance of the cells NTP pool, nm23 plays a key role in different cellular processes. The role of nm23-H1 in these processes still has to be elucidated. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

3 Samples

Download data: CEL

(Submitter supplied) Identification of genes that are differentially regulated in fibroblasts derived from dysplastic oral mucosa and oral squamous cell carcinoma compared to fibroblasts derived from normal oral mucosa. Affymetrix microarrays were used to define differential gene expression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

20 Samples

Download data: CEL

(Submitter supplied) In an attempt to further elucidate the pathomechanisms in oral squamous cell carcinoma (OSCC), gene expression profiling to a set of 35 primary OSCCs compared to 6 oral mucosa from healthy non-tumor patients was performed. Keywords: expression profiling

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6353

41 Samples

Download data: GPR

(Submitter supplied) The elevation of guanine nucleotide binding protein alpha 12 (Gα12) expression is highly associated with tumor invasiveness in several human cancers. We used an siRNA strategy to deplete Gα12 in oral squamous cell carcinoma (OSCC) cells and analyze the transcriptome profile by the Affymetrix Human Exon 1.0 ST platform.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

4 Samples

Download data: CEL, CHP