Similar studies for GEO DataSets (Select 200035953) - GEO DataSets

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Items: 20

Select item 2000359531.

High-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)

(Submitter supplied) Less than 30% of children with high-risk (HR) metastatic neuroblastoma (NB) show a long survival (Pearson 2000). In order to identify novel molecular prognostic markers useful to better predict patients’ relapse risk estimation, we performed genome- and/or transcriptome-wide analyses of 129 stage 4 HR-NBs. This is the largest study for this NB subtype. Children older than 1 year of age at diagnosis were categorized as “short-survivors” (dead of disease within 5 years from diagnosis) and “long-survivors” (alive with an overall survival time > 5 years). more...

Organism:: Homo sapiens

Type:: Genome variation profiling by array

Platforms:: GPL2873 GPL5477
35 Samples

Download data: TXT

Series

Accession:: GSE35953

ID:: 200035953

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000057842.

Array-based comparative genomic hybridization analysis of primary neuroblastoma

(Submitter supplied) We conducted microarray-based comparative genomic hybridization (array-CGH) with a DNA chip carrying 2,464 BAC clones to examine genomic aberrations of 236 neuroblastomas (112 sporadic and 124 mass screening-detected). In paralell, gene-expression profiling was also performed by using in-house cDNA microarrays. Keywords: Comparative genomic hybridization

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL4242
236 Samples

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Series

Accession:: GSE5784

ID:: 200005784

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000131413.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by SNP array; SNP genotyping by SNP array

Platforms:: GPL2004 GPL570
53 Samples

Download data: CEL

Series

Accession:: GSE13141

ID:: 200013141

Select item 2000131374.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: SNP data

(Submitter supplied) Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations. Genomic copy number losses and gains had been delineated in the tumours using FISH and SNP arrays. We have identified genes significantly altered by 7 recurrent alterations: 1p, 3p, 4p, 10q and 11q loss, 2p and 17q gain, and genes co-amplified and over-expressed as a result of MYCN amplification. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:: GPL2004
23 Samples

Download data: CEL

Series

Accession:: GSE13137

ID:: 200013137

PubMed Similar studies

Select item 2000131365.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: expression data

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
30 Samples

Download data: CEL

Series

Accession:: GSE13136

ID:: 200013136

Select item 2000086346.

Array-CGH screening of medulloblastoma

(Submitter supplied) DNA copy-number profiling of 80 primary medulloblastomas of different histologies Keywords: Genetic modification

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL5685
80 Samples

Download data: GPR

Series

Accession:: GSE8634

ID:: 200008634

Select item 2000257717.

High-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)

(Submitter supplied) Neuroblastoma (NB) is an aggressive tumor that affects both infants and children. The disease outcome is greatly influenced by age of patient, stage, chromosome copy number aberrations (CNAs) and gene expression abnormalities. We analyzed, by microarray technology, genome and transcriptome of 3 groups of tumors of patients with metastatic disease: G1, stage 4S and MYCN single copy; G2, stage 4 younger than 18 months of age, MYCN single copy with no disease progression and G3, stage 4, older than 19 months, with unfavorable outcome. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by array

4 related Platforms
133 Samples

Download data: TXT

Series

Accession:: GSE25771

ID:: 200025771

Select item 2001121738.

Genomic profiles of unresectable localized peripheral neuroblastic tumours without MYCN amplificatioun of children over the age of 12 months

(Submitter supplied) Background: The prognostic impact of segmental chromosome alterations (SCAs) in children older than 1 year, diagnosed with localised unresectable neuroblastoma (NB) without MYCN amplification enrolled in the European Unresectable Neuroblastoma (EUNB) protocol is still to be clarified, while, for other group of patients, the presence of SCAs is associated with poor prognosis. Methods: To understand the role of SCAs we performed multilocus/pangenomic analysis of 98 tumour samples from patients enrolled in the EUNB protocol. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL13906 GPL24759 GPL9715
26 Samples

Download data: GPR, PAIR, TXT

Series

Accession:: GSE112173

ID:: 200112173

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Select item 2000392189.

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.

(Submitter supplied) Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is amplified in 20% of neuroblastomas, and these tumors carry a poor prognosis. However, tumors without MYCN amplification also may have a poor outcome. Here, we identified downstream targets of MYCN by shRNA-mediated silencing MYCN in neuroblastoma cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
11 Samples

Download data: CEL

Series

Accession:: GSE39218

ID:: 200039218

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010312310.

Copy number profiling of 556 high-risk neuroblastoma patients using aCGH or SNP arrays

(Submitter supplied) Purpose: Neuroblastoma is characterized by substantial clinical heterogeneity. Despite intensive treatment, the survival rates of high-risk neuroblastoma patients are still disappointingly low. Somatic chromosomal copy number aberrations have been shown to be associated with patient outcome, particularly in low- and intermediate-risk neuroblastoma patients. To improve outcome prediction in high-risk neuroblastoma, we aimed to design a prognostic classification method based on copy number aberrations. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array; Genome variation profiling by SNP array; Third-party reanalysis

Download data: TXT, XLSX

Series

Accession:: GSE103123

ID:: 200103123

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Select item 20021852711.

Impact of Genomic and Clinical Factors on Outcome of Children ≥18 Months of Age with INSS Stage 3 Neuroblastoma with Unfavorable Histology without MYCN Amplification

(Submitter supplied) Patients with INSS stage 3, MYCN–non-amplified, unfavorable histology neuroblastoma represent a rare subset of children with outcomes that are inferior to those of most patients with advanced locoregional disease, and superior to those of most high-risk patients. We evaluated the impact of clinical variables on outcome and used available tumor samples from subjects within this subgroup to correlate whole exome sequencing (WES) and RNA sequencing (RNASeq) profiles with outcome. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
47 Samples

Download data: TXT

Series

Accession:: GSE218527

ID:: 200218527

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Select item 20000344612.

Gene expression profiles of primary tumors from patients with metastatic neuroblastoma lacking MYCN amplification

(Submitter supplied) Metastatic neuroblastomas lacking amplification of the MYCN proto-oncogene vary in their clinical behavior. Those diagnosed before one year of age are least aggressive and those diagnosed after two years are most aggressive. To improve current risk stratification and gain insight into the biological processes that account for this phenomenon, we analyzed expression profiles from 102 primary untreated neuroblastomas. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL96 GPL97
234 Samples

Download data

Series

Accession:: GSE3446

ID:: 200003446

Select item 20002649413.

array-CGH profiling of human neuroblastoma samples obtained from infants included in the INES99.1, INES99.2 and INES99.3 trials

(Submitter supplied) In neuroblastoma (NB), the presence of segmental chromosome alterations (SCA) is associated with a higher risk of relapse, even when occurring together with numerical chromosome alterations (NCA). Furthermore, recent evidence shows that SCAs play a role in tumor progression. In order to analyze the role of SCAs in infants with NB, we have performed an extensive retrospective array-CGH analysis of tumours from infants enrolled in the European INES 99.1, 99.2 and 99.3 trials. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array; Genome variation profiling by array

5 related Platforms
218 Samples

Download data: GFF, GPR, PAIR, PDF, TXT

Series

Accession:: GSE26494

ID:: 200026494

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Select item 20006241914.

FOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma

(Submitter supplied) Single-color gene expression profiles from 3 neuroblastoma cell lines were generated using 44K oligonucleotide microarrays. To gain insights into the molecular processes occurring upon FOXP1 re-expression, we performed series of time-resolved gene expression measurements in FOXP1 and GFP transgenic neuroblastoma cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16876
24 Samples

Download data: TXT

Series

Accession:: GSE62419

ID:: 200062419

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20020972815.

Affymetrix CytoScan HD data on neuroblastoma cell lines

(Submitter supplied) Neuroblastomas are characterized by recurrent segmental and/or numerical chromosomal abberations such as MYCN-amplification or 11q-deletion. To further elucidate recurrent chromosomal alterations, 16 neuroblastoma cell lines were investigated.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platform:: GPL16131
16 Samples

Download data: CEL, CYCHP

Series

Accession:: GSE209728

ID:: 200209728

PubMed Full text in PMC Similar studies

Select item 20026211116.

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations [Parse scRNA-seq]

(Submitter supplied) Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs contribute to embryonic tumourigenesis due to a lack of suitable models. Here we employ female human embryonic stem cell (hESC) differentiation and single-cell transcriptome and epigenome analysis to assess the effects of chromosome 17q/1q gains, which are prevalent in the embryonal tumour neuroblastoma (NB). more...