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Series GSE3446 Query DataSets for GSE3446
Status Public on Sep 06, 2006
Title Gene expression profiles of primary tumors from patients with metastatic neuroblastoma lacking MYCN amplification
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Metastatic neuroblastomas lacking amplification of the MYCN proto-oncogene vary in their clinical behavior. Those diagnosed before one year of age are least aggressive and those diagnosed after two years are most aggressive. To improve current risk stratification and gain insight into the biological processes that account for this phenomenon, we analyzed expression profiles from 102 primary untreated neuroblastomas. A 55 gene model classified patients diagnosed after 12 months of age based on molecular risk with an error rate of 17.5%. The progression-free survival for this group was 16% and 79% if their tumors had molecular high or low risk profiles (p<0.001). Expression profiles of tumors with molecular high-risk features included genes relating to regulation of growth and programmed cell death. This series also includes 15 samples obtained at disease relapse. Fourteen out of the fifteen samples had molecular high risk features.
Keywords: repeat
 
Overall design 102 samples obtained at diagnosis were analyzed for model generation and compared to 15 obtained at relapse, using Affymetrix HG-U133A (GPL96) and HG-U133B (GPL97) platforms.
 
Contributor(s) Asgharzadeh S, Seeger RC
Citation(s) 16954472
Submission date Oct 13, 2005
Last update date Aug 10, 2018
Contact name Shahab Asgharzadeh
E-mail(s) [email protected]
Phone 310-669-2121
Fax 310-664-9455
Organization name Childrens Hospital Los Angeles
Department Hematology-Oncology
Lab Neural Tumors Laboratory
Street address 4650 Sunset Boulevard, Mail Stop #57
City Los Angeles
State/province CA
ZIP/Postal code 90027
Country USA
 
Platforms (2)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL97 [HG-U133B] Affymetrix Human Genome U133B Array
Samples (234)
GSM77819 Neuroblastoma tumor 86057 (GPL96)
GSM77820 Neuroblastoma tumor 86114 (GPL96)
GSM77821 Neuroblastoma tumor 86120 (GPL96)
Relations
BioProject PRJNA93373

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