GEO DataSets

(Submitter supplied) Spalax, an underground fossoral rodant is exposed to chronic hypoxic environments. Measurements of Spalax burrows indicated 7% oxygen and up to 15% CO2. In the laboratory Spalax can survive 3% oxygen up to 14 hours as compared to rats that survive less than 4 hours at these oxygen levels. we have proposed Spalax as a model species for the investigation of hypoxia tolerance. this research has implications for many biomedical phenomena involving ischemic disease, notably heart disease and cancer. more...

Organism:

Rattus norvegicus; Nannospalax galili

Type:

Expression profiling by array

Platforms:

GPL14746 GPL15478

28 Samples

Download data: GPR

(Submitter supplied) This study compares response to hypoxia in muscle between 2 hypoxia tolerant species of Spalax ehrenbergi, blind subterranean mole rat . The blind subterranean mole rat (Spalax ehrenbergi superspecies) is an excellent model of hypoxic tolerance, living underground and exposed to fluctuating O2 and CO2 levels. Unique structural and functional adaptations of the cardiovascular and respiratory systems allow survival at severely reduced oxygen tension. more...

Organism:

Mus musculus; Nannospalax ehrenbergi; Nannospalax galili; Nannospalax judaei

Type:

Expression profiling by array

Platform:

GPL3236

12 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Nannospalax ehrenbergi

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL17021 GPL25363

39 Samples

Download data

(Submitter supplied) Background: Spalax, the blind mole rat, developed an extraordinary cancer resistance during 40 million years of evolution in a subterranean, hypoxic, thus DNA damaging, habitat. In 50 years of Spalax research, no spontaneous cancer development has been observed. The mechanisms underlying this resistance are still not clarified. We investigated the genetic difference between Spalax and mice that might enable the Spalax relative resistance to cancer development. more...

Organism:

Mus musculus; Nannospalax ehrenbergi

Type:

Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL17021 GPL25363

14 Samples

Download data: CSV

(Submitter supplied) Background: Spalax, the blind mole rat, developed an extraordinary cancer resistance during 40 million years of evolution in a subterranean, hypoxic, thus DNA damaging, habitat. In 50 years of Spalax research, no spontaneous cancer development has been observed. The mechanisms underlying this resistance are still not clarified. We investigated the genetic difference between Spalax and mice that might enable the Spalax relative resistance to cancer development. more...

Organism:

Mus musculus; Nannospalax ehrenbergi

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17021 GPL25363

25 Samples

Download data: CSV

(Submitter supplied) Placenta transcriptome from two species of Spalax. Associated with the article "Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax."

Organism:

Nannospalax galili; Spalax carmeli

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17526 GPL20184

2 Samples

Download data: FASTA, TXT

(Submitter supplied) Deep sequencing of mRNA from Spalax galili and Rattus norvegicus

Organism:

Rattus norvegicus; Nannospalax galili

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17526 GPL14844

12 Samples

Download data: BEDGRAPH

(Submitter supplied) High altitude environments are characterized by the unique and unavoidable stress of chronic hypoxia. While much is known about gene expression responses to acute or in vitro hypoxia, less is known about the gene expression profiles of animals exposed to systemic chronic hypoxia, such as that experienced at high elevations. Here we simulated the hypoxic environment of two high altitude elevations,and a third chamber recieved ambient Reno air. more...

Organism:

Mus musculus; Mus musculus domesticus

Type:

Expression profiling by array

Dataset:

GDS4929

Platform:

GPL1261

8 Samples

Download data: CEL

Analysis of livers of C57BL/6 males housed for 32 days in chambers that simulated the hypoxic environment of an altitude of 1400, 3000, or 4500 meters. Results provide insight into the molecular mechanisms underlying acclimatization to high altitude hypoxia.

Organism:

Mus musculus; Mus musculus domesticus

Type:

Expression profiling by array, transformed count, 3 stress sets

Platform:

GPL1261

Series:

GSE15891

8 Samples

Download data: CEL

(Submitter supplied) In this study, we determined the effect of chronic consistent hypoxia (CCH) and chronic intermittent hypoxia (CIH) on global gene expression in cortical and hippocampal region of developing mouse brain using long-oligo beadschip arrays. Keywords: Gene expression profile

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3114

Platform:

GPL5402

18 Samples

Download data: TXT

Analysis of brain cortices and hypothalami of developing animals subjected to chronic consistent hypoxia (CCH) or chronic intermittent hypoxia (CIH). Results provide insight into the molecular mechanisms underlying the long-lasting pathological effects of hypoxia on postnatal brain development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 stress, 2 tissue sets

Platform:

GPL5402

Series:

GSE8262

18 Samples

Download data

(Submitter supplied) Adaptation to hypoxia, a hallmark feature of many tumors, is an important driver of cancer cell survival, proliferation and the development of resistance to chemotherapy. Hypoxia-induced stabilization of hypoxia-inducible factors (HIFs) leads to transcriptional activation of a network of hypoxia target genes involved in angiogenesis, cell growth, glycolysis, DNA damage repair and apoptosis. Although the transcriptional targets of hypoxia have been characterized, the alternative splicing of transcripts that occurs during hypoxia and the roles they play in oncogenesis are much less understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

3 Samples

Download data: BW

(Submitter supplied) Hypoxia, which characterizes most tumor tissues, can alter the function of different immune cell types, favoring tumor escape mechanisms. In this study, we show that hypoxia profoundly acts on NK cells by influencing their transcriptome, affecting their immunoregulatory functions, and changing the chemiotactic responses of different NK cell subsets.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

12 Samples

Download data: CEL

(Submitter supplied) The molecular response to hypoxia is a critical cellular process implicated in cancer, and a target for drug development. The activity of the major player, HIF1α, is regulated at different levels, including the transcriptional level by the Ets factor ELK3. The molecular mechanisms of this intimate transcriptional connection remain largely unknown. Whilst investigating global ELK3-chromatin interactions, we uncovered an unexpected connection that involves the microRNA hsa-miR-155-5p, a hypoxia-inducible oncomir that targets HIF1α. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL16791

2 Samples

Download data: XLSX

(Submitter supplied) Background: Constant hypoxia (CH) and intermittent hypoxia (IH) occur during several pathological conditions such as asthma and obstructive sleep apnea. Our research is focused on understanding the molecular mechanisms that lead to injury or adaptation to hypoxic stress using Drosophila as a model system. Our current genome-wide study is designed to investigate gene expression changes and identify protective mechanism(s) in D. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

9 Samples

Download data: CEL

(Submitter supplied) 6-8 week old BL6, FVB/N and SV129 mouse strains were kept in normoxia or hypobaric hypoxia for 4 weeks and then phenotyped by echocardiogram and right ventricular heart catheterization, followed by tissue collection. In addition, Affymetrix expression analysis was conducted in a paired fashion. Keywords: Differential response to hypoxia by strain

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

9 Samples

Download data: CEL, CHP

(Submitter supplied) Analysis of gene expression profile of B16-F10 murine melanoma cells exposed to hypoxic conditions (1% oxygen) or hypoxia mimicry (cobalt chloride) for 24 hours. Gene expression profiles were analyzed using MG-U74Av2 oligonucleotide microarrays. Data analysis revealed 2541 probesets (FDR<5%) for 1% oxygen experiment and 364 probesets (FDR<5%) for cobalt chloride, that showed differences in expression levels. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

21 Samples

Download data: CEL

(Submitter supplied) In order to study the gene expression profile in C57Bl/10 mouse blood, we exposed three different groups of animals. First was exposed to PO2 21% or normoxia. The second was exposed to chronic hypoxia (from PO2 21% to PO2 8%) and the third was also exposed to the same chronic hypoxia (CH) protocol but followed by two weeks under normoxia, and called as recovery group. The blood was extracted from inferior vena cava, the RNA was extracted, amplified and hybridized to Affimetrix MOE 430 V2.o chip. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

12 Samples

Download data: CEL, CHP