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Links from GEO DataSets

Items: 20

1.

Time-course expression data during assurance of the chronological longevity by caloric restriction in budding yeast

(Submitter supplied) Caloric restriction (CR) is the only non-genetic intervention to retard aging and increase longevity in a variety of species. It is important to understand the fundamental mechanism by which CR extends lifespan that remains elusive. Owing to well-established genomic tools and convenience of culture system, we used a single cell organism, Saccharomyces cerevisiae, to clarify the mechanisms of CR. In order to identify genes responsible for CR-mediated longevity, we performed microarray experiments across the longevity assurance time-points.
Organism:
Schizosaccharomyces pombe; Saccharomyces cerevisiae BY4741; Saccharomyces cerevisiae
Type:
Expression profiling by array
Platform:
GPL2529
24 Samples
Download data: CEL, CHP
Series
Accession:
GSE41860
ID:
200041860
2.

Gene expression changes in yeast cells deleted for Nat4 and cells grown in calorie-restriction

(Submitter supplied) We report here mRNA-seq data of wild-type and Nat4-deletion mutant yeast cells. We also report mRNA-seq data of wild-type yeast cells grown under non-calorie restriction (NCR) and calorie restriction (CR) conditions.
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13821
4 Samples
Download data: TXT
Series
Accession:
GSE86242
ID:
200086242
3.

Comparative transcriptome profiling analyses during the lag phase uncover YAP1, PDR1, PDR3, RPN4 and HSF1 as key regulatory genes in genomic adaptation to the lignocellulose derived inhitibor-stress for saccharomyces cerevisiae

(Submitter supplied) The yeast Saccharomyces cerevisiae is able to adapt and in situ detoxify lignocellulose derived inhibitors such as furfural and HMF. The length of lag phase for cell growth in response to the inhibitor challenge has been used to measure tolerance of strain performance. Mechanisms of yeast tolerance at the genome level remain unknown. Using systems biology approache, this study investigated comparative transcriptome profiling, metabolic profiling, cell growth response and gene regulatory interactions of yeast strains and selective gene deletion mutations in response to HMF challenges during the lag phase of growth. more...
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array
Platform:
GPL10684
14 Samples
Download data: GPR
Series
Accession:
GSE22939
ID:
200022939
4.

BY_wild_parents

(Submitter supplied) Expression analysis of BY4716(isogenic to S288c) and a wild isolate collected by R. Mortimer. Each strain was grown in culture 6 independent times and RNA from each culture was isolated. Each of these RNA samples was subjected to a dye-swap pair of arrays (except the "RM11" sample, which only got one array). All arrays used the same pool of reference BY4716 sample. In sample titles, "BY" alone signifies the reference sample and all other strings represent independent cultures. more...
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array
Datasets:
GDS93 GDS94
Platform:
GPL118
23 Samples
Download data
Series
Accession:
GSE38
ID:
200000038
5.

BYxwild_40

(Submitter supplied) Expression analysis of F1 haploid segregants from a cross between BY4716 (isogenic to S288c) and a wild isolate collected by R. Mortimer. Each segregant sample was subjected to a dye-swap pair of arrays. All arrays used the same pool of reference BY4716 sample. In sample titles, "BY" alone signifies the reference sample and all other strings represent segregants. All sample titles are of the form S1-S2. more...
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array
Datasets:
GDS91 GDS92
Platform:
GPL118
80 Samples
Download data
Series
Accession:
GSE37
ID:
200000037
6.
Full record GDS94

Transcriptional regulation (II)(dye-swap)

Genetic linkage analysis of global expression levels in a cross between two budding yeast strains. Identification of cis-acting and trans-acting loci that modulate a total of 570 genes.
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array, log ratio, 2 strain sets
Platform:
GPL118
Series:
GSE38
11 Samples
Download data
DataSet
Accession:
GDS94
ID:
94
7.
Full record GDS93

Transcriptional regulation (II)

Genetic linkage analysis of global expression levels in a cross between two budding yeast strains. Identification of cis-acting and trans-acting loci that modulate a total of 570 genes.
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array, log ratio, 2 strain sets
Platform:
GPL118
Series:
GSE38
12 Samples
Download data
DataSet
Accession:
GDS93
ID:
93
8.
Full record GDS92

Transcriptional regulation (I)(dye-swap)

Genetic linkage analysis of global expression levels in a cross between two budding yeast strains. Identification of cis-acting and trans-acting loci that modulate a total of 570 genes.
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array, log ratio, 7 other sets
Platform:
GPL118
Series:
GSE37
40 Samples
Download data
DataSet
Accession:
GDS92
ID:
92
9.
Full record GDS91

Transcriptional regulation (I)

Genetic linkage analysis of global expression levels in a cross between two budding yeast strains. Identification of cis-acting and trans-acting loci that modulate a total of 570 genes.
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array, log ratio, 7 other sets
Platform:
GPL118
Series:
GSE37
40 Samples
Download data
DataSet
Accession:
GDS91
ID:
91
10.

Chronological Aging of Yeast in SD medium

(Submitter supplied) Yeast grown in synthetic complete medium (SD) until glucose depletion is aged chronologically. Cells are stressed by lacking of nutrients and accumulating toxic substances, and thus undergo gene expression changes in response to those. We performed microarray experiments to capture gene expression profiles of yeast cultured at 4 different time points.
Organism:
Schizosaccharomyces pombe; Saccharomyces cerevisiae
Type:
Expression profiling by array
Platform:
GPL2529
12 Samples
Download data: CEL
Series
Accession:
GSE55508
ID:
200055508
11.

Calorie Restricted and Non-Restricted Yeast

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Saccharomyces cerevisiae
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL13821
10 Samples
Download data: BW
Series
Accession:
GSE53721
ID:
200053721
12.

RNA-seq Experiments from Saccharomyces cerevisiae

(Submitter supplied) RNA-seq Experiments from Calorie Restricted and Non-Restricted WT Yeast
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13821
4 Samples
Download data: TXT
Series
Accession:
GSE53720
ID:
200053720
13.

MNase-seq Experiments from Saccharomyces cerevisiae

(Submitter supplied) MNase-seq Experiments from Calorie Restricted and Non-Restricted Yeast from WT, ISW2DEL and ISW2K215R strains
Organism:
Saccharomyces cerevisiae
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13821
6 Samples
Download data: BW
Series
Accession:
GSE53718
ID:
200053718
14.

Time-course gene expression profiles of a Saccharomyces cerevisiae wild type and long-lived sch9-delta mutant

(Submitter supplied) The SCH9 null strain has smaller cell size, grows at a slower rate and survives three times longer than wide-type yeast. This study aims to dissect the mechanisms that lead to the yeast life span extension of sch9-delta.
Organism:
Schizosaccharomyces pombe; Saccharomyces cerevisiae
Type:
Expression profiling by array
Platform:
GPL2529
19 Samples
Download data: CEL
Series
Accession:
GSE14227
ID:
200014227
15.

Ssd1 and Gcn2 suppress global translational efficiency in replicatively aged yeast, while their activation in young cells extends lifespan

(Submitter supplied) Using ribosome profiling, we find globally reduced translation efficiency during mitotic / replicative aging in budding yeast. Two mechanisms contribute to this: Firstly, the mRNA binding protein Ssd1 is induced during aging, sequestering mRNAs to P-bodies and stress granules that are abundant in old cells. Indeed, overexpression of Ssd1 reduced protein synthesis in young cells and extended lifespan, while loss of Ssd1 reduced the translational deficit of old cells and shortened lifespan. more...
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL13821
18 Samples
Download data: WIG, XLS
Series
Accession:
GSE104506
ID:
200104506
16.

Gene expression profile from short-term caloric restriction in mouse adipose tissue

(Submitter supplied) To provide a robust understanding of a transcriptomic change by short-term CR at body fat of mice, we applied three serial strengths of CR to mice including 15%, 30%, and 45% reduction of carbon source. Using Affymetrix mouse 1.0 ST array platform, we obtained and analyzed the transcriptome data for significantly changed genes in expression. Here, we identified 446 genes and categorized the genes based on their biological roles. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE60596
ID:
200060596
17.

Diauxic shift

(Submitter supplied) Exploring the metabolic and genetic control of gene expression on a genomic scale in yeast. This study is described in more detail in DeRisi JL et al. 1997. Science 278:680-6 Keywords: time-course
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array
Dataset:
GDS37
Platform:
GPL57
7 Samples
Download data
Series
Accession:
GSE28
ID:
200000028
18.
Full record GDS37

Diauxic shift time course

Gene expression patterns accompanying the metabolic shift from anaerobic fermentation to aerobic respiration. Samples taken at several time points up to 20.5 h.
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array, log ratio, 7 time sets
Platform:
GPL57
Series:
GSE28
7 Samples
Download data
DataSet
Accession:
GDS37
ID:
37
19.

RNAseq and ribosome profiling of yeast cells grown under methionine restriction condition.

(Submitter supplied) We characterize the translational and transcriptional programs induced by MetR and investigate the potential mechanisms through which methionine regulates gene expression, using the budding yeast S. cerevisiae as the model organism. Using ribosomal profiling and RNA-seq, we systematically compared the translational and transcriptional profiles of cells growing in the normal and methionine restricted media. more...
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13821
4 Samples
Download data: WIG
Series
Accession:
GSE91068
ID:
200091068
20.

Calorie Restriction Feminizes Liver Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

(Submitter supplied) Background: Calorie restriction (CR) is the only intervention known to extend lifespan in a wide range of organisms, including mammals. However, the mechanisms by which it regulates mammalian aging remain largely unknown and the involvement of the TOR and Sirtuin pathways (which regulate aging in lower organisms) remain controversial. Femaleness is a second phenotype generally associated with longevity but the relationship between sex-biased and CR-induced gene expression remains undetermined. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6761
23 Samples
Download data: GPR
Series
Accession:
GSE11244
ID:
200011244
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