Similar studies for GEO DataSets (Select 200045635) - GEO DataSets

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Items: 20

Select item 2000456351.

Expression Profiles of HepG2 cells treated with Cyclosporin A and solvent control

(Submitter supplied) The transcriptomics changes induced in the human liver cell line HepG2 by Cyclosporin A after treatment for 12h, 24h, 48h and 72h

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16311
36 Samples

Download data: CEL

Series

Accession:: GSE45635

ID:: 200045635

Select item 2000458022.

Expression Profiles of mRNAs and microRNAs in HepG2 cells treated with Cyclosporin A and solvent control

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus; Rattus norvegicus

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL16311 GPL16968
72 Samples

Download data: CEL, TXT

Series

Accession:: GSE45802

ID:: 200045802

Select item 2000458003.

Expression Profiles of microRNAs of HepG2 cells treated with Cyclosporin A and solvent control

(Submitter supplied) The microRNA changes induced in the human liver cell line HepG2 by Cyclosporin A after treatment for 12h, 24h, 48h and 72h

Organism:: Homo sapiens; Rattus norvegicus; Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL16968
36 Samples

Download data: TXT

Series

Accession:: GSE45800

ID:: 200045800

Select item 2000558834.

Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL15967 GPL17912
46 Samples

Download data: CEL, TXT

Series

Accession:: GSE55883

ID:: 200055883

Select item 2000558815.

Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control [RNA]

(Submitter supplied) The transcriptomics changes induced in Primary Mouse Hepatocytes by Cyclosporin A after treatment for 24h and 48h

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL15967
24 Samples

Download data: CEL, TXT

Series

Accession:: GSE55881

ID:: 200055881

Select item 2000558806.

Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control [miRNA]

(Submitter supplied) The microRNA changes induced in Primary Mouse Hepatocytes of C57Bl6-mice by Cyclosporin A after treatment for 24h and 48h

Organism:: Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL17912
22 Samples

Download data: TXT

Series

Accession:: GSE55880

ID:: 200055880

Select item 2000556187.

Toxicogenomic profiling in the whole zebrafish embryo after exposure to reference hepatotoxicants.

(Submitter supplied) Zebrafish embryos have been proposed as an attractive alternative model system for hepatotoxicity testing. In this study we determined gene expression responses after exposure to reference hepatotoxicants and controls to identify biomarkers for hepatotoxicity.

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL18378
188 Samples

Download data: CEL

Series

Accession:: GSE55618

ID:: 200055618

Select item 2000519698.

Gene expression profiles of acetaminophen, isoniazid, and paraquat treated C57BL/6 mice

(Submitter supplied) Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of necrosis in C57BL/6 mice treated by oral gavage using acetaminophen (APAP), isoniazid (INZ), and paraquat (PQ). Critical doses for tgx analysis were derived from a 25 day dose range finding study. For tgx analysis, livers of mice were collected 1 and 2 days after a single compound dose of 168.75, 225, and 300 mg/kg bw for APAP; 12.5, 25, and 50 mg/kg bw for PQ; and 22, 44, and 88 mg/kg bw for INZ. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17226
69 Samples

Download data: CEL

Series

Accession:: GSE51969

ID:: 200051969

Select item 2000481269.

Gene expression profiles of amiodarone, valproic acid, and tetracycline induced steatosis in C57BL/6 mice

(Submitter supplied) Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of steatosis in C57BL/6 mice treated by oral gavage using amiodarone (AMD), valproic acid (VPA), and tetracycline (TET). Critical doses for tgx analysis were derived from a 25 day dose range finding study. For tgx analysis, livers of mice were collected after 1, 4, and 11 days of repeated treatment with 6.7, 20, and 60 mg/kg bw for AMD; 125, 250, and 500 mg/kg bw for VPA; and 14.8, 44, and 133 mg/kg bw for TET.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17226
95 Samples

Download data: CEL

Series

Accession:: GSE48126

ID:: 200048126

Select item 20003154010.

Gene expression profiles for onset and progression of Cyclosporin A-induced cholestasis in C57BL/6 mice

(Submitter supplied) Mechanism-based toxicogenomics (tgx) is used as a tool to identify markers reflective of the onset and progression of cholestasis in C57BL/6 mice using Cyclosporin A (CsA) as a model compound. Critical doses for tgx analysis were derived from a dose range finding study in which increase of serum cholesterol, total bile acids, and total bilirubin as well as induction of hepatocyte vacuolization 25 days upon repeated CsA administration through oral gavage were considered as critical effects. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL14178
58 Samples

Download data: CEL

Series

Accession:: GSE31540

ID:: 200031540

Select item 20008428111.

Integrative "-omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL16284 GPL17996 GPL18402
53 Samples

Download data: CEL, PAIR, TXT

Series

Accession:: GSE84281

ID:: 200084281

Select item 20008427612.

Integrative "-omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis (MeDIP)

(Submitter supplied) Cyclosporine A (CsA), is an endecapeptide with strong immunosuppressant activities and has contributed significantly towards clinical progress in organ transplantation. Furthermore, it has various toxic effects in the kidney and especially in the liver where it may induce cholestasis. The CsA drug-induced cholestasis (DIC) pathway includes important genes involved in the uptake, synthesis, conjugation and secretion of bile acids, which can be verified also in hepatic models in vitro. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
18 Samples

Download data: PAIR, TXT

Series

Accession:: GSE84276

ID:: 200084276

PubMed Similar studies

Select item 20008395813.

Integrative "-omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis (RNA)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17996
18 Samples

Download data: CEL

Series

Accession:: GSE83958

ID:: 200083958

Select item 20008395414.

Integrative "-omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis (miRNA)

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL18402
17 Samples

Download data: TXT

Series

Accession:: GSE83954

ID:: 200083954

Select item 20005425715.

Drug-induced liver injury

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL14996 GPL13158
116 Samples

Download data: CEL

Series

Accession:: GSE54257

ID:: 200054257

Select item 20005425616.

Expression data from primary mouse hepatocytes treated with Diclofenac

(Submitter supplied) Drug-induced liver injury (DILI) is an important clinical problem. Here we used a genomics approach to establish the critical drug-induced toxicity pathways that act in synergy with the pro-inflammatory cytokine tumor necrosis factor  (TNF) to cause cell death of liver HepG2 cells. Transcriptomics of the cell injury stress response pathways initiated by two hepatoxicants, diclofenac and carbamazepine, revealed the endoplasmic reticulum (ER) stress/translational initiation signaling and Nrf2 antioxidant signaling as two major affected pathways, which was similar to that observed for the majority of ~80 DILI compounds in primary human hepatocytes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL14996
10 Samples

Download data: CEL

Series

Accession:: GSE54256

ID:: 200054256

Select item 20005425517.

Gene expression data from precision cut human liver slices treated to diclofenac

(Submitter supplied) Drug-induced liver injury (DILI) is an important clinical problem. Here we used a genomics approach to establish the critical drug-induced toxicity pathways that act in synergy with the pro-inflammatory cytokine tumor necrosis factor (TNF) to cause cell death of liver HepG2 cells. Transcriptomics of the cell injury stress response pathways initiated by two hepatoxicants, diclofenac and carbamazepine, revealed the endoplasmic reticulum (ER) stress/translational initiation signaling and Nrf2 antioxidant signaling as two major affected pathways, which was similar to that observed for the majority of ~80 DILI compounds in primary human hepatocytes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
10 Samples

Download data: CEL

Series

Accession:: GSE54255

ID:: 200054255

Select item 20005425418.

Expression data from human hepatocellular carcinoma cell line HepG2

(Submitter supplied) Drug-induced liver injury (DILI) is an important clinical problem. Here we used a genomics approach to establish the critical drug-induced toxicity pathways that act in synergy with the pro-inflammatory cytokine tumor necrosis factor (TNF) to cause cell death of liver HepG2 cells. Transcriptomics of the cell injury stress response pathways initiated by two hepatoxicants, diclofenac and carbamazepine, revealed the endoplasmic reticulum (ER) stress/translational initiation signaling and Nrf2 antioxidant signaling as two major affected pathways, which was similar to that observed for the majority of ~80 DILI compounds in primary human hepatocytes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
96 Samples

Download data: CEL

Series

Accession:: GSE54254

ID:: 200054254

Select item 20005195219.

Expression Profiles of HepG2 cells treated with 22 compounds and solvent controls

(Submitter supplied) The transcriptomics changes induced in the human liver cell line HepG2 by 17 hepatotoxic compounds, 5 non-hepatotoxic compounds and solvent controls after treatment for 24h