GEO DataSets

(Submitter supplied) Colorectal cancer (CRC) is a genetically heterogeneous disease with several distinct morphological growth patterns. This study was aimed to investigate genes differentially expressed between ulcerative and polypoid colorectal CRC. cDNA microarray was first employed to compare the gene expression profiling of ulcerative and polypoid CRC with paired normal mucosa. Potential candidates identified by data filtering were further validated using quantitative real-time polymerase chain reaction, western blot and immunohistochemistry. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17157

16 Samples

Download data: GPR

(Submitter supplied) To identify new markers for colorectal cancer we scrutinized the methylation status by methyl-CpG immunoprecipitation followed by global methylation profiling on a CpG island microarray, as altered expression could drive genomic and chromosomal instability observed in these tumors. We show for the first time hypermethylation of MMP9, DNMT3A, and LIG4 in CRC which was confirmed in two independent ethnic CRC patients groups. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL9767

16 Samples

Download data: TXT

(Submitter supplied) We had previously demonstrated an increased proapoptotic effect of Imatinib (STI571) in combination with Amifostine (AMI) in K562 cell line. In this study we used genomic scale gene expression profiling to monitor changes at transcriptional level in K562 cells during the treatment with AMI+STI571. We identified a transcriptional repressor of survival genes, known as BTF, which triggers a pro-apoptotic signal, potentially helpful to overcome the resistance to STI571. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2829

4 Samples

Download data

(Submitter supplied) The purpose of our study was to better understand the genetic mechanism of oncogenesis for human colorectal cancer and to identify potential new tumour markers of use in clinical practice. Results: Comparing cancerous tissues with normal colonic mucosa we identified 584 known genes (3%) differentially expressed to a significant degree (p<0.001). Many of the transcripts that were more abundant in tumours than in non-neoplastic tissues appear to reflect important events for colon carcinogenesis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2829

24 Samples

Download data

(Submitter supplied) Unearthing of silenced genes in colorectal cancer (CRC) is of great importance. We employed oligonucleotide microarray to find changes in global gene expression of five CRC cell lines. These were analyzed before and after treatment with the 5-aza-2'-Deoxycitidine. Expression of the responding genes was integrated with gene expression profiling generated by microarray analysis of matched colorectal tissue samples. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4382 GDS4397

Platform:

GPL570

44 Samples

Download data: CEL

Analysis of colorectal cancer (CRC) cell lines treated with 5-aza-2’-deoxycytidine (5-aza-dC). 5-aza-dC, a DNA methylation inhibitor, was used to reactivate silenced genes in the CRC cell lines. Results provide insight into the molecular mechanisms underlying epigenetic alterations in CRC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 5 cell line sets

Platform:

GPL570

Series:

GSE32323

10 Samples

Download data: CEL

Analysis of paired colorectal cancer (CRC) tumors and adjacent non-cancerous tissues. Colorectal cancer is a worldwide public health problem. Results provide insight into the molecular mechanisms underlying CRC carcinogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 17 individual, 2 tissue sets

Platform:

GPL570

Series:

GSE32323

34 Samples

Download data: CEL

(Submitter supplied) Purpose: This study aimed to identify a novel biomarker or a target of treatment for colorectal cancer (CRC). Experimental Design: The expression profiles of cancer cells in 104 patients with CRC were examined using laser microdissection and oligonucleotide microarray analysis. Overexpression in CRC cells especially in patients with distant metastasis was a prerequisite to select candidate genes. The mRNA expression of candidate gene was investigated by quantitative reversetranscription polymerase chain reaction (RT-PCR) in 77 patients as a validation study. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4516 GDS4718

Platform:

GPL570

148 Samples

Download data: CEL

Analysis of homogenized colorectal cancer (CRC) tumors representing various stages and metastases. Results provide insight into predictive biomarkers of metastasis and treatment targets in CRC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 7 other sets

Platform:

GPL570

Series:

GSE21510

44 Samples

Download data: CEL

Analysis of LCM-isolated colorectal cancer (CRC) tumors representing various stages and metastases. Results provide insight into predictive biomarkers of metastasis and treatment targets in CRC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 7 other sets

Platform:

GPL570

Series:

GSE21510

104 Samples

Download data: CEL

(Submitter supplied) We found GAP43 was significantly downregulated in colorectal cancer. So we reintroduced GAP43 to colorectal cancer cell line, and investigated the influence to cancer cells. In order to get the transcriptome-wide impact of GAP43 overexpression in colorectal cancer, we made stable transfected GAP43 in SW620 cancer cells, and mRNA-seq were performed (Sequenced with PE150, and 20M reads were generated.) This study provides the DEGs of GAP43 overexpressed and control colorectal cancer cells.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20795

4 Samples

Download data: XLSX

(Submitter supplied) We have used a combination of RNAi based functional and molecular genomic approaches to investigate in detail two proteins required for the survival of CRC cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

89 Samples

Download data: TXT

(Submitter supplied) The naphthalene diimide compound QN-302, designed to bind to G-quadruplex DNA sequences within the promoter regions of cancer-related genes, has high anti-proliferative activity in pancreatic cancer cell lines and anti-tumor activity in several experimental models for the disease. We show here that QN-302 also causes down-regulation of the expression of the S100P gene and the S100P protein in cells and in vivo. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

7 Samples

Download data: XLSX

(Submitter supplied) Colorectal cancer (CRC) incidence increases with age and early onset of the disease is an indication of genetic predisposition, estimated to cause up to 30 % of all CRC cases. To identify genes associated with an increased risk for CRC, genome-wide gene expression levels of CRCs from patients diagnosed at an early age and CRCs from patients diagnosed at higher age were investigated. Patients with known hereditary predisposition syndromes were excluded from the study.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5232

Platform:

GPL2986

50 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5175 GPL11028

333 Samples

Download data: CEL, CHP

(Submitter supplied) Colorectal cancer is a heterogeneous disease molecularly characterized by inherent genomic instabilities, chromosome instability and microsatellite instability. In the present study we propose transcriptome instability as an analogue to genomic instability on the transcriptome level. Exon microarray data from two independent series of altoghether 160 colorectal cancer tissue samples was used for global alternative splicing detection using the FIRMA algorithm (aroma.affymetrix). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL11028 GPL5175

167 Samples

Download data: CEL, CHP

Analysis of primary colorectal cancer (CRC) tumors from patients diagnosed with CRC at an early age (28 to 53 years of age) and patients diagnosed at a later age (69 to 87 years). Results identify genes associated with early onset CRC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 age, 2 gender, 2 tissue sets

Platform:

GPL2986

Series:

GSE25071

50 Samples

Download data: TXT

(Submitter supplied) The aim was to investigate the effect of postoperative intra-abdominal infection on the gene expression patterns of peripheral blood leukocytes (PBL) after surgery for colorectal cancer

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

62 Samples

Download data: CEL

(Submitter supplied) The aim was to analyze the transcriptome of different types of preneoplastic colorectal lesions in comparison with that of the corresponding normal mucosa.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

92 Samples

Download data: CEL

(Submitter supplied) To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC) we generated mice deficient for cyclin A2 in colonic epithelial cells (CEC). Colons of those mice displayed architectural changes in the mucosa, and signs of inflammation as well as an increased proliferation of CEC associated with the appearance of low- and high-grade dysplasia. The main initial events triggering those alterations in cyclin A2 deficient CEC appear to be abnormal mitoses and DNA damage. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

8 Samples

Download data: TXT