Similar studies for GEO DataSets (Select 200047473) - GEO DataSets

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Items: 20

Select item 2000474731.

Global gene expression profiling using total RNA [BMM, MPI and SPG]

(Submitter supplied) Differentiation of myeloid progenitor cells leads to distinct populations of mononuclear phagocytes.Various macrophages exhibit distinct biological properties. Here wanted to delineate and characterize gene expression patterns in bone marrow derived macrophages Here wanted to delineate and characterize gene expression patterns in two newly established, self-renewing, in vitro grown non-transformed lines (MPI cells) and in the SP37A3 immature myeloid dendritic cell line. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
12 Samples

Download data: CEL

Series

Accession:: GSE47473

ID:: 200047473

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000769992.

Capacity of yolk sac macrophages, fetal liver and adult monocytes to colonize an empty niche and develop into functional tissue resident macrophages

(Submitter supplied) Tissue-resident macrophages can derive from yolk sac macrophages, fetal liver monocytes or adult bone marrow monocytes. Whether these precursors can give rise to transcriptionally identical alveolar macrophages is unknown. Here, we transferred traceable yolk sac macrophages, fetal liver monocytes, adult bone marrow monocytes or adult alveolar macrophages as a control, into the empty alveolar macrophage niche of neonatal Csf2rb-/- mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
36 Samples

Download data: CEL

Series

Accession:: GSE76999

ID:: 200076999

Select item 2000887683.

Identification of PPARG regulated genes in human GM-CSF-primed monocyte-derived macrophages

(Submitter supplied) Identification of PPARG regulated genes in human GM-CSF polarized monocyte-derived macrophages by siRNA knock-down approaches.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21185
6 Samples

Download data: TXT

Series

Accession:: GSE88768

ID:: 200088768

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000271614.

The Cytokines IL-21 and GM-CSF have Opposing Regulatory Roles in the Apoptosis of Conventional Dendritic Cells

(Submitter supplied) Interleukin-21 (IL-21) has broad actions on T- and B-cells, but its actions in innate immunity are poorly understood. Here we show that IL-21 induced apoptosis of conventional dendritic cells (cDCs) via STAT3 and Bim, and this was inhibited by granulocyte-macrophage colony-stimulating factor (GM-CSF). ChIP-Seq analysis revealed genome-wide binding competition between GM-CSF-induced STAT5 and IL-21-induced STAT3. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9185
6 Samples

Download data: BED

Series

Accession:: GSE27161

ID:: 200027161

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000277925.

Human monocyte-derived macrophages polarized by GM-CSF or M-CSF

(Submitter supplied) Identification of genes differentially expressed between human monocyte-macrophages generated in the presence of either GM-CSF (termed M1) or M-CSF (termed M2)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL11010
6 Samples

Download data: TXT

Series

Accession:: GSE27792

ID:: 200027792

Select item 2000146726.

GM-CSF-mediated granulopoiesis is regulated by the transcription factor STAT5A/B

(Submitter supplied) GM-CSF controls the development of granulocytes but little is known about the contribution of the downstream mediating transcription factor STAT5A/B. To elucidate this pathway, we generated mice lacking the Stat5a and 5b genes in blood cells. Peripheral neutrophils were decreased and administration of 5-FU and GM-CSF failed to induce granulopoiesis in Stat5a/b-mutant mice. GMPs were isolated and cultured with GM-CSF. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE14672

ID:: 200014672

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000632457.

Gene expression data from murine M1 and M2 macrophages

(Submitter supplied) Macrophages have distinct characteristics depending on their microenvironment. We performed proteomic analysis between M1 and M2 macrophages and found that cellular metabolism is the key regulator of macrophage function. We used microarray to support proteomic data between M1 and M2 macrophages.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
4 Samples

Download data: CEL

Series

Accession:: GSE63245

ID:: 200063245

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000534268.

Gene expression and genotype data from human fibroblasts and induced Pluripotent Stem cells from Parkinson's Disease patients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; SNP genotyping by SNP array

Platforms:: GPL13829 GPL10558
14 Samples

Download data

Series

Accession:: GSE53426

ID:: 200053426

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000534259.

SNP data from human fibroblasts and induced Pluripotent Stem cells from Parkinson's Disease patients

(Submitter supplied) We have generated human induced Pluripotent Stem cells (hiPSc) from Parkinson's Disease patients, using retrovirus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotency of the hiPSc lines is provided by Pluritest assessment of transcriptome datasets, prior to differentiation to dopaminergic neuronal clutures and downstream functional assays. more...

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platform:: GPL13829
9 Samples

Download data: TXT

Series

Accession:: GSE53425

ID:: 200053425

PubMed Full text in PMC Similar studies

Select item 20005342410.

Gene expression data from human fibroblasts and induced Pluripotent Stem cells from Parkinson's Disease patients

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
5 Samples

Download data: TXT

Series

Accession:: GSE53424

ID:: 200053424

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20026584011.

BHLHE40 regulates myeloid cell polarization through IL-10-dependent and independent mechanisms

(Submitter supplied) Better understanding of the host responses to Mycobacterium tuberculosis (Mtb) infections is required to prevent tuberculosis and develop new therapeutic interventions. The host transcription factor BHLHE40 is essential for controlling Mtb infection, in part by repressing Il10 expression, where excess IL-10 contributes to the early susceptibility of Bhlhe40-/- mice to Mtb infection. Deletion of Bhlhe40 in lung macrophages and dendritic cells is sufficient to increase the susceptibility of mice to Mtb infection, but how BHLHE40 impacts macrophage and dendritic cell responses to Mtb is unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
27 Samples

Download data: TXT

Series

Accession:: GSE265840

ID:: 200265840

PubMed

Select item 20006024912.

PPARγ controls alveolar macrophage identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
12 Samples

Download data: CEL

Series

Accession:: GSE60249

ID:: 200060249

Select item 20006024813.

PPARγ controls alveolar macrophage identity [part2]

(Submitter supplied) Tissue-resident macrophages comprise heterogeneous populations with unique functions and distinct gene expression signatures. While it has been established that they mostly originate from embryonic progenitors, the signals inducing a characteristic tissue-specific differentiation program remain unknown. Here we identify PPARγ as the crucial transcription factor determining perinatal alveolar macrophage (AM) development and identity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
4 Samples

Download data: CEL

Series

Accession:: GSE60248

ID:: 200060248

Select item 20006024714.

PPARγ controls alveolar macrophage identity [part1]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
8 Samples

Download data: CEL

Series

Accession:: GSE60247

ID:: 200060247

Select item 20004514515.

The impact of breed genotype and tissue compartment on the response of pig macrophages to lipopolysaccharide

(Submitter supplied) The domestic pig (Sus scrofa) provides a large animal model for human innate immune responses and inflammation that is also economically important in its own right. Results: We demonstrate that macrophages can be harvested from 3 different compartments of the pig (lungs, blood and bone-marrow), cryopreserved and subsequently recovered and differentiated in CSF-1. We have performed surface marker analysis and gene expression profiling on macrophages from these compartments, comparing 25 animals from 5 different breeds and their response to lipopolysaccharide. more...

Organism:: Sus scrofa

Type:: Expression profiling by array

Platform:: GPL16569
140 Samples

Download data: CEL

Series

Accession:: GSE45145

ID:: 200045145

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20019025916.

Expression data from human alveolar macrophages (AMs)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24539
17 Samples

Download data: CEL, CHP

Series

Accession:: GSE190259

ID:: 200190259

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Select item 20019025717.

Expression data from human alveolar macrophages (AMs) of fetal versus adult origin

(Submitter supplied) The impact of cell origin on human lung macrophage identity and function remains unknown. In this study we characterized human alveolar macrophages of fetal versus adult origin. We used microarray to define the gene signatures of human alveolar macrophages derived from CD116+CD64+ fetal monocytes, CD116+CD64- fetal precursors, and CD34+ HSPCs in MISTRG humanized mice.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24539
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE190257

ID:: 200190257

PubMed Full text in PMC Similar studies

Select item 20019025618.

Expression data from different types of human alveolar macrophage (AM) precursors

(Submitter supplied) Despite their importance in lung health and disease, it remains unknown how human alveolar macrophages develop early in life. In this study we identified the fetal progenitor of human alveolar macrophages. We used microarray to define the gene signatures of human CD14+ blood monocytes (adult AM precursors), CD116+CD64+ fetal liver monocytes, and CD116+CD64- fetal AM precursors.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24539
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE190256

ID:: 200190256

PubMed Full text in PMC Similar studies

Select item 20003658519.

IL-4 stimulation of Dicer deficient bone-marrow derived macrophages in vitro

(Submitter supplied) Macrophages were derived from the bone-marrow of 3 x fl/+ Dicer LysCre +/- (wild-type) and 3 x fl/fl Dicer LysCre +/- mice and stimulated with IL-4 (50ng/mL) for 72h. Total RNA was isolated and analyzed by gene array.