Similar studies for GEO DataSets (Select 200048126) - GEO DataSets

Select item 2000481261.

Gene expression profiles of amiodarone, valproic acid, and tetracycline induced steatosis in C57BL/6 mice

(Submitter supplied) Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of steatosis in C57BL/6 mice treated by oral gavage using amiodarone (AMD), valproic acid (VPA), and tetracycline (TET). Critical doses for tgx analysis were derived from a 25 day dose range finding study. For tgx analysis, livers of mice were collected after 1, 4, and 11 days of repeated treatment with 6.7, 20, and 60 mg/kg bw for AMD; 125, 250, and 500 mg/kg bw for VPA; and 14.8, 44, and 133 mg/kg bw for TET.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17226
95 Samples

Download data: CEL

Series

Accession:: GSE48126

ID:: 200048126

Select item 2000556182.

Toxicogenomic profiling in the whole zebrafish embryo after exposure to reference hepatotoxicants.

(Submitter supplied) Zebrafish embryos have been proposed as an attractive alternative model system for hepatotoxicity testing. In this study we determined gene expression responses after exposure to reference hepatotoxicants and controls to identify biomarkers for hepatotoxicity.

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL18378
188 Samples

Download data: CEL

Series

Accession:: GSE55618

ID:: 200055618

Select item 2000519693.

Gene expression profiles of acetaminophen, isoniazid, and paraquat treated C57BL/6 mice

(Submitter supplied) Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of necrosis in C57BL/6 mice treated by oral gavage using acetaminophen (APAP), isoniazid (INZ), and paraquat (PQ). Critical doses for tgx analysis were derived from a 25 day dose range finding study. For tgx analysis, livers of mice were collected 1 and 2 days after a single compound dose of 168.75, 225, and 300 mg/kg bw for APAP; 12.5, 25, and 50 mg/kg bw for PQ; and 22, 44, and 88 mg/kg bw for INZ. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17226
69 Samples

Download data: CEL

Series

Accession:: GSE51969

ID:: 200051969

Select item 2000315404.

Gene expression profiles for onset and progression of Cyclosporin A-induced cholestasis in C57BL/6 mice

(Submitter supplied) Mechanism-based toxicogenomics (tgx) is used as a tool to identify markers reflective of the onset and progression of cholestasis in C57BL/6 mice using Cyclosporin A (CsA) as a model compound. Critical doses for tgx analysis were derived from a dose range finding study in which increase of serum cholesterol, total bile acids, and total bilirubin as well as induction of hepatocyte vacuolization 25 days upon repeated CsA administration through oral gavage were considered as critical effects. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL14178
58 Samples

Download data: CEL

Series

Accession:: GSE31540

ID:: 200031540

Select item 2000515455.

Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17326
76 Samples

Download data: CEL

Series

Accession:: GSE51545

ID:: 200051545

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000515446.

Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices [Cholestatic compounds exposures]

(Submitter supplied) Although drug induced steatosis represents a mild type of hepatotoxicity, it can progress into more severe non-alcoholic steatohepatitis. Current models used for safety assessment in drug development and chemical risk assessment do not accurately predict steatosis in humans. Therefore, new models need to be developed to screen compounds for steatogenic properties. We have studied the usefulness of mouse precision-cut liver slices (PCLS) as an alternative to animal testing to gain more insight into the mechanisms involved in the steatogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17326
30 Samples

Download data: CEL

Series

Accession:: GSE51544

ID:: 200051544

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000515437.

Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices [Steatogenic compounds exposures]

(Submitter supplied) Although drug induced steatosis represents a mild type of hepatotoxicity, it can progress into more severe non-alcoholic steatohepatitis. Current models used for safety assessment in drug development and chemical risk assessment do not accurately predict steatosis in humans. Therefore, new models need to be developed to screen compounds for steatogenic properties. We have studied the usefulness of mouse precision-cut liver slices (PCLS) as an alternative to animal testing to gain more insight into the mechanisms involved in the steatogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17326
23 Samples

Download data: CEL

Series

Accession:: GSE51543

ID:: 200051543

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000515428.

Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices [Necrotic compounds exposures]

(Submitter supplied) Although drug induced steatosis represents a mild type of hepatotoxicity, it can progress into more severe non-alcoholic steatohepatitis. Current models used for safety assessment in drug development and chemical risk assessment do not accurately predict steatosis in humans. Therefore, new models need to be developed to screen compounds for steatogenic properties. We have studied the usefulness of mouse precision-cut liver slices (PCLS) as an alternative to animal testing to gain more insight into the mechanisms involved in the steatogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17326
23 Samples

Download data: CEL

Series

Accession:: GSE51542

ID:: 200051542

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000134659.

Acetaminophen-induced gene expression profiles in sandwich-cultured primary rat hepatoctyes

(Submitter supplied) The frequent use of rodent hepatic in vitro systems in pharmacological and toxicological investigations challenges extrapolation of in vitro results to the situation in vivo and interspecies extrapolation from rodents to humans. The toxicogenomics approach may aid in evaluating relevance of these model systems for human risk assessment by direct comparison of toxicant-induced gene expression profiles and infers mechanisms between several systems. more...

Organism:: Homo sapiens; Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL887 GPL890
33 Samples

Download data: TXT

Series

Accession:: GSE13465

ID:: 200013465

Select item 20001343010.

Acetaminophen-induced gene expression profiles in sandwich-cultured primary human hepatocytes

(Submitter supplied) The frequent use of rodent hepatic in vitro systems in pharmacological and toxicological investigations challenges extrapolation of in vitro results to the situation in vivo and interspecies extrapolation from rodents to humans. The toxicogenomics approach may aid in evaluating relevance of these model systems for human risk assessment by direct comparison of toxicant-induced gene expression profiles and infers mechanisms between several systems. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL887
15 Samples

Download data: TXT

Series

Accession:: GSE13430

ID:: 200013430

Select item 20006254711.

In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells.

(Submitter supplied) Human skin-derived precursor cells (hSKP) are a post natal stem cell population isolated from the dermis. These cells acquire hepatic characteristics upon differentiation with hepatogenic factors. Differentiated hSKP show characteristics of hepatocyte precursor cells and respond to hepatotoxic compounds in a comparable way as human hepatocyte cultures. We used microarray analyses to evaluate the modulation of gene expression due to exposure to a steatosis-inducing compound.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE62547

ID:: 200062547

Select item 20008425012.

Induction of changes in primary human hepatocytes by valproic acid

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by genome tiling array; Non-coding RNA profiling by array

Platforms:: GPL16284 GPL16770 GPL16356
35 Samples

Download data: CEL, PAIR, TXT

Series

Accession:: GSE84250

ID:: 200084250

Select item 20008423913.

Induction of miRNA changes in primary human hepatocytes by valproic acid

(Submitter supplied) Valproic acid (VPA) is a very potent anti-cancer and neuro-protective drug. However, exposure to VPA may cause accumulation of lipids in the liver which could result in the development of steatosis. As VPA is a fatty acid analogue, most of the performed studies focus on inhibition of the mitochondrial b-oxidation pathway as the possible mode of action. However, investigations exploring the contribution of other processes in particular by using whole genome studies in a relevant human liver model are limited. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL16770
11 Samples

Download data: TXT

Series

Accession:: GSE84239

ID:: 200084239

Select item 20008418914.

Induction of DNA methylation changes in primary human hepatocytes by valproic acid

(Submitter supplied) Valproic acid (VPA) is a very potent anti-cancer and neuro-protective drug. However, exposure to VPA may cause accumulation of lipids in the liver which could result in the development of steatosis. As VPA is a fatty acid analogue, most of the performed studies focus on inhibition of the mitochondrial b-oxidation pathway as the possible mode of action. However, investigations exploring the contribution of other processes in particular by using whole genome studies in a relevant human liver model are limited. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
12 Samples

Download data: PAIR, TXT

Series

Accession:: GSE84189

ID:: 200084189

PubMed Similar studies

Select item 20008415015.

Induction of gene expression changes in primary human hepatocytes by valproic acid

(Submitter supplied) Valproic acid (VPA) is a very potent anti-cancer and neuro-protective drug. However, exposure to VPA may cause accumulation of lipids in the liver which could result in the development of steatosis. As VPA is a fatty acid analogue, most of the performed studies focus on inhibition of the mitochondrial b-oxidation pathway as the possible mode of action. However, investigations exploring the contribution of other processes in particular by using whole genome studies in a relevant human liver model are limited. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16356
12 Samples

Download data: CEL

Series

Accession:: GSE84150

ID:: 200084150

Select item 20013881016.

Role of Farnesoid X Receptor (FXR) in Valproic acid-induced Hepatotoxicity

(Submitter supplied) Drug-induced steatosis and steatohepatitis manifest clinically as nonalcoholic fatty liver disease (NAFLD). Drugs associated with steatosis include valproic acid (VPA). VPA has been one of the most widely used antiepileptic drugs over the past 40 years. However, clinical follow-up studies have reported that more than 40% of patients who received VPA also developed fatty liver disease. Steatosis is a typical clinical effect of VPA treatment and is characterized by an abnormal accumulation of lipids in liver cells. more...