Similar studies for GEO DataSets (Select 200054255) - GEO DataSets

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Items: 20

Select item 2000542551.

Gene expression data from precision cut human liver slices treated to diclofenac

(Submitter supplied) Drug-induced liver injury (DILI) is an important clinical problem. Here we used a genomics approach to establish the critical drug-induced toxicity pathways that act in synergy with the pro-inflammatory cytokine tumor necrosis factor (TNF) to cause cell death of liver HepG2 cells. Transcriptomics of the cell injury stress response pathways initiated by two hepatoxicants, diclofenac and carbamazepine, revealed the endoplasmic reticulum (ER) stress/translational initiation signaling and Nrf2 antioxidant signaling as two major affected pathways, which was similar to that observed for the majority of ~80 DILI compounds in primary human hepatocytes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
10 Samples

Download data: CEL

Series

Accession:: GSE54255

ID:: 200054255

Select item 2000542572.

Drug-induced liver injury

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL14996 GPL13158
116 Samples

Download data: CEL

Series

Accession:: GSE54257

ID:: 200054257

Select item 2000542563.

Expression data from primary mouse hepatocytes treated with Diclofenac

(Submitter supplied) Drug-induced liver injury (DILI) is an important clinical problem. Here we used a genomics approach to establish the critical drug-induced toxicity pathways that act in synergy with the pro-inflammatory cytokine tumor necrosis factor  (TNF) to cause cell death of liver HepG2 cells. Transcriptomics of the cell injury stress response pathways initiated by two hepatoxicants, diclofenac and carbamazepine, revealed the endoplasmic reticulum (ER) stress/translational initiation signaling and Nrf2 antioxidant signaling as two major affected pathways, which was similar to that observed for the majority of ~80 DILI compounds in primary human hepatocytes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL14996
10 Samples

Download data: CEL

Series

Accession:: GSE54256

ID:: 200054256

Select item 2000542544.

Expression data from human hepatocellular carcinoma cell line HepG2

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
96 Samples

Download data: CEL

Series

Accession:: GSE54254

ID:: 200054254

Select item 2001020065.

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

(Submitter supplied) To unravel the underlying mechanisms of inflammation-related idiosyncratic drug toxicity

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
252 Samples

Download data: TXT

Series

Accession:: GSE102006

ID:: 200102006

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000558836.

Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL15967 GPL17912
46 Samples

Download data: CEL, TXT

Series

Accession:: GSE55883

ID:: 200055883

Select item 2000558817.

Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control [RNA]

(Submitter supplied) The transcriptomics changes induced in Primary Mouse Hepatocytes by Cyclosporin A after treatment for 24h and 48h

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL15967
24 Samples

Download data: CEL, TXT

Series

Accession:: GSE55881

ID:: 200055881

Select item 2000558808.

Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control [miRNA]

(Submitter supplied) The microRNA changes induced in Primary Mouse Hepatocytes of C57Bl6-mice by Cyclosporin A after treatment for 24h and 48h

Organism:: Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL17912
22 Samples

Download data: TXT

Series

Accession:: GSE55880

ID:: 200055880

Select item 2000848639.

RNA sequencing of MDA-MB231 and U2OS cancer cell lines exposed to the alkylating agent methyl methanesufonate (MMS) and classical chemotherapeutics

(Submitter supplied) Understanding the mechanisms by which cells respond to chemotherapeutics is key to identifying means to improve therapy effiicacy while reducing systemic toxicity of these widely used classes of drugs. While determining the role of NRF2-GSH and ER stress in cells exposed to alkylating compounds such as methyl-methanesulfonate (MMS), we asked if these pathways could also be a general cell damage response relevant to other clinically used chemotherapeutics or if it is an alkylation specific response. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
11 Samples

Download data: TXT

Series

Accession:: GSE84863

ID:: 200084863

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20007527710.

The genomic responses of mouse liver to diclofenac treatment reveals an immune mediated mechanism of liver injury

(Submitter supplied) Diclofenac (DCL) is a non-steroidal anti-inflammatory drug. Its use can be associated with serious adverse drug reactions most notable myocardial infarction and drug-induced liver injury (DILI). The molecular causes leading to DILI remains unclear and it seems to be multifactorial. The aims of this study is to identify the molecular mechanisms involving immune mediated inflammatory reactions and its link to DILI through whole genome gene expression profiling. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
22 Samples

Download data: CEL, CHP

Series

Accession:: GSE75277

ID:: 200075277

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012266011.

Treatment of human hepatoma and primary human hepatocyte cultures (PHH) with fatty acids and/or fatty acids and TNFa

(Submitter supplied) Treatment of the human hepatoma cell lines HepG2, HUH7 and PHH with a mixture of fatty acids caused heaptic steatosis. The combined lipid and TNFa treatment mimics inflammation. Cells were harvested and processed for microarray analysis

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
33 Samples

Download data: CEL, CHP

Series

Accession:: GSE122660

ID:: 200122660

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20015285212.

Gene expression data from Collaborative Cross mice treated with TAK-857

(Submitter supplied) Eight (8) male mice (4 matched pairs) from each of 45 Collaborative Cross lines were treated with a single oral (gavage) dose of either vehicle (methylcellulose) or TAK-875 (600 mg/kg) to facilitate the evaluation of very early liver events in the pathogenesis of IDILI and the identification of genetic risk factors that influence toxicity susceptibility at the hepatocyte level Microarray profiling in the liver identified treatment-induced changes differing by strain and correlating with serum liver chemistries that were enriched in mitochondrial dysfunction, oxidative stress, bile acid homeostasis and immune response pathways suggesting multiple mechanisms contribute to TAK-875 toxicity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
342 Samples

Download data: CEL

Series

Accession:: GSE152852

ID:: 200152852

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012308213.

Transcriptomic analysis of endoplasmic reticulum stress (ERS) regulated genes in mouse gastrocnemius muscle

(Submitter supplied) One gastrocnemius muscle was injected with the ERS-drug tunicamycin, the other with control saline solution and muscles were used to prepare RNA.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
18 Samples

Download data: CEL

Series

Accession:: GSE123082

ID:: 200123082

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012261314.

ChIP-seq analysis of changes in H3K27ac by endoplasmic reticulum stress (ERS) in mouse primary hepatocytes.

(Submitter supplied) Mouse primary hepatocytes (MPH) prepared from C57Bl6 male adult mice were treated with the ERS-drug thapsigargin and ChIP-seq was performed using an H3K27ac antibody (Active Motif ref 39685).

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
8 Samples

Download data: BED

Series

Accession:: GSE122613

ID:: 200122613

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012250815.

Transcriptomic and epigenomic analysis of endoplasmic reticulum stress signaling in mouse primary hepatocytes and liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21103 GPL16570
52 Samples

Download data: CEL

Series

Accession:: GSE122508

ID:: 200122508

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012250716.

Transcriptomic analysis of endoplasmic reticulum stress (ERS) regulated genes in mouse primary hepatocytes.

(Submitter supplied) Mouse primary hepatocytes (MPH) prepared from C57Bl6 male adult mice were treated with the ERS-drug thapsigargin and used to prepare RNA.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
6 Samples

Download data: CEL

Series

Accession:: GSE122507

ID:: 200122507

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012250617.

Transcriptomic analysis of endoplasmic reticulum stress (ERS) regulated genes in the liver of NFIL3 KO mice.

(Submitter supplied) Livers from wild-type (WT) or NFIL3 knock-out (NFIL3 KO) C57Bl6 mal adult mice treated with the ERS-drug tunicamycin were used to prepare RNA.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
20 Samples

Download data: CEL

Series

Accession:: GSE122506

ID:: 200122506

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011214018.

Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice

(Submitter supplied) Fasiglifam (TAK-875), a G protein-coupled receptor 40 (GPR40) agonist, was a drug candidate for type 2 diabetes. However, its development was terminated in phase 3 trials due to liver safety concerns. Although TAK-875 was reported to inhibit hepatobiliary transporters and disturb bile acid disposition, pathogenic mechanisms of TAK-875-induced liver injury are not fully understood. In this study, we sought to identify the mechanisms with a hepatic genome-wide transcriptomic analysis in a murine model. more...