Similar studies for GEO DataSets (Select 200055227) - GEO DataSets

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Items: 20

Select item 2000552271.

Gene expression analysis of Cbfb-deficient LSK and GMP

(Submitter supplied) Runx/Cbfb heterodimers play important roles in the development of hematopoietic cells in mouse embryos and adults. In order to identify genes that are regulated by Runx/Cbfb, we purified Lin– c-kit+ Sca1+ (LSK) cells and Lin– c-kit+ Sca1– CD16/32+ (GMP) cells from Vav1-iCre x Cbfb(F/F) and Vav1-iCre x Cbfb(F/+) mice and profiled gene expression using microarray.

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS5413 GDS5414
Platform:: GPL6246
8 Samples

Download data: CEL

Series

Accession:: GSE55227

ID:: 200055227

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 54142.

Core binding factor β deficiency effect on bone marrow derived-granulocyte macrophage progenitor cells

Analysis of purified Lin-c-kit+Sca1-CD16/32+ GMP cells from Cbfβ-conditional knockout mice. Runx/Cbfb heterodimers play important roles in hematopoietic cell development. Results provide insight into molecular mechanisms by which Cbfβ regulates cell fate decisions in bone marrow progenitors.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE55227
4 Samples

Download data: CEL

DataSet

Accession:: GDS5414

ID:: 5414

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 54133.

Core binding factor β deficiency effect on bone marrow derived-LSK hematopoietic stem cells

Analysis of purified Lin-c-kit+Sca1+ LSK cells from Cbfβ- conditional knockout mice. Runx/Cbfb heterodimers play important roles in hematopoietic cell development. Results provide insight into molecular mechanisms by which Cbfβ regulates cell fate decisions in bone marrow progenitors.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE55227
4 Samples

Download data: CEL

DataSet

Accession:: GDS5413

ID:: 5413

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001303804.

RNA-seq analyses of two intestinal dendritic cell subsets, CD103+CD11b- and CD103-CD11b+, from wild type and CbfbF/F:CD11c-Cre mice.

(Submitter supplied) We report phenotypes in gut dendritic cell development by loss of Runx/Cbfb transcription factor complexes. To further examine function of residual CD103+CD11b- and CD103-CD11b+ DCs, we performed RNA-seq analyses and compared gene expression signatures between control and Cbfb-deficient cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TXT

Series

Accession:: GSE130380

ID:: 200130380

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001525735.

RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemogenesis

(Submitter supplied) Inversion of chromosome 16 is a consistent finding in patients with acute myeloid leukemia subtype M4 with eosinophilia (AML M4Eo), which generates a CBFB-MYH11 fusion gene. It is generally considered that CBFβ-SMMHC, the fusion protein encoded by CBFB-MYH11, is a dominant negative repressor of RUNX1. However, recent findings challenge the RUNX1-repression model for CBFβ-SMMHC mediated leukemogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL21626 GPL24247 GPL21493
33 Samples

Download data: BEDPE, DIFF, H5, TXT

Series

Accession:: GSE152573

ID:: 200152573

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000191946.

Cbfb/Runx1-repression independent blockage of differentiation and accumulation of Csf2rb expressing cells by Cbfb-MYH11

(Submitter supplied) It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in human acute myeloid leukemia, is causative for oncogenic transformation. However, the mechanism by which CBFB-MYH11 initiates leukemogenesis is not clear. Previously published reports showed that CBFB-MYH11 dominantly inhibits RUNX1 and CBFB, and such inhibition has been suggested as the mechanism for leukemogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4040
Platform:: GPL1261
14 Samples

Download data: CEL, CHP

Series

Accession:: GSE19194

ID:: 200019194

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 40407.

Leukemia in Cbfb+/MYH11 embryos: peripheral blood

Analysis of peripheral blood from Cbfb+/MYH11 and Cbfb-/- E12.5 embryos with that of their wildtype littermates. Cbfb+/MYH11 embryos had defects in both primitive and definitive hematopoiesis. Results provide insight into the mechanisms by which CBFB-MYH11 may contribute to leukemogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 3 genotype/variation, 2 specimen sets

Platform:: GPL1261
Series:: GSE19194
14 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4040

ID:: 4040

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000811538.

Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.

(Submitter supplied) Gene expression in control and Flt3-ITD, Stat5 and Runx1 mutant HSCs and HPCs from different developmental stages.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL10787 GPL21163
117 Samples

Download data: TXT

Series

Accession:: GSE81153

ID:: 200081153

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000349179.

IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL1261 GPL15097
13 Samples

Download data: CEL

Series

Accession:: GSE34917

ID:: 200034917

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003491510.

IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors (Illumina).

(Submitter supplied) While most blood lineages are assumed to mature through a single cellular and developmental route downstream of hematopoietic stem cells (HSCs), dendritic cells (DCs) can be derived from both myeloid and lymphoid progenitors in vivo. To determine how distinct progenitors can generate similar downstream lineages, we examined the transcriptional changes that accompany loss of in vivo myeloid potential as common myeloid progenitors (CMPs) differentiate into common dendritic cell progenitors (CDPs), and as lymphoid-primed multipotent progenitors (LMPPs) differentiate into all lymphoid progenitors (ALPs). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL15097
8 Samples

Download data: TXT

Series

Accession:: GSE34915

ID:: 200034915

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003489211.

IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors (Affymetrix).

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
5 Samples

Download data: CEL

Series

Accession:: GSE34892

ID:: 200034892

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000070212.

Antigen Presenting Dendritic Cells

(Submitter supplied) Assessing the gene expression repertoire of antigen presenting dendritic cells Keywords: other

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL81
7 Samples

Download data

Series

Accession:: GSE702

ID:: 200000702

Select item 20000069313.

Lin-c-kit+Sca1+ hematopoetic stem cells

(Submitter supplied) sorted hematopoetic stem cells from bone marrow; with two rounds of amplification Keywords: repeat sample

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL81
2 Samples

Download data

Series

Accession:: GSE693

ID:: 200000693

Select item 20000069214.

FLT3+/CD11b+ Dendritic cell (DC) progenitor

(Submitter supplied) FLT3+/CD11b+ Dendritic cell (DC) progenitor was amplified in vitro from mouse bone marrow. Keywords: repeat sample

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL81
5 Samples

Download data

Series

Accession:: GSE692

ID:: 200000692

Select item 20000057515.

DC differentiation from DC progenitor in vitro

(Submitter supplied) FLT3+CD11b+ DC progenitor was amplified in vitro from mouse bone marrow. DC were differentiated using GM-CSF and analyzed at day 7 and day 10 of differentiation and after 16h TNFalpha stimulation at day 10 Keywords: time-course

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2440
Platform:: GPL32
4 Samples

Download data

Series

Accession:: GSE575

ID:: 200000575

Select item 244016.

Dendritic cell development in vitro

Analysis of dendritic cell (DC) development from Flt3(+)CD11b(+) DC progenitors. DC progenitors treated with GM-CSF for 7 and 10 days to induce differentiation. DCs differentiated for 10 days were subsequently treated with TNFalpha to induce maturation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 protocol sets

Platform:: GPL32
Series:: GSE575
4 Samples

Download data

DataSet

Accession:: GDS2440

ID:: 2440

Select item 20001814817.

Microarray analysis of Cbfb-deficient regulatory T cells

(Submitter supplied) Gene expression profiles of Cbfb-deficient and control Treg cells were compared. Abstract: Naturally arising regulatory T (Treg) cells express the transcription factor FoxP3, which critically controls the development and function of Treg cells. FoxP3 interacts with another transcription factor Runx1 (also known as AML1). Here we showed that Treg cell-specific deficiency of Cbfβ, a cofactor for all Runx proteins, or that of Runx1, but not Runx3, induced lymphoproliferation, autoimmune disease, and hyper-production of IgE. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3577
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE18148

ID:: 200018148

Select item 357718.

Cbfbeta deficiency effect on regulatory T cells

Analysis of regulatory T cells lacking Cbfbeta. Cbfbeta is a cofactor for the Runx family of transcription factors. Results provide insight into the role of the Runx1-Cbfbeta transcription complex in regulatory T cell function.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE18148
6 Samples

Download data: CEL

DataSet

Accession:: GDS3577

ID:: 3577

Select item 20006689919.

Batf3 maintains Irf8 autoactivation for commitment of a novel clonogenic progenitor of CD8+DCs

(Submitter supplied) The transcription factors Batf3 and IRF8 are required for development of CD8α+ conventional dendritic cells (cDCs), but the basis for their actions was unclear. Here, we identify two novel Zbtb46+ progenitors that separately generate CD8α+ and CD4+ cDCs and arise directly from the common DC progenitor (CDP). Irf8 expression in the CDP depends on prior PU.1-dependent autoactivation, and specification of pre-CD8 DC progenitors requires IRF8 but not Batf3. more...