GEO DataSets

(Submitter supplied) The project examined age-related change in hippocampal gene expression in Fisher 344 x Brown Norway F1 rats from the NIA aging colony (Adult = 12M, Aged = 24M). CA1, CA3, and DG specific dissections were examined from one cohort of animals and from a second cohort whole hippocampus was used.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

60 Samples

Download data: TXT

(Submitter supplied) Previous studies of age-related transcriptional changes indicate that cognitive impairments are associated with differentially expressed genes DEGs linked to defined neural systems; however, studies that examine multiple regions of the hippocampus fail to find major links between behavior and transcription in the dentate gyrus DG. The DG is implicated in pattern separation PS and exhibits multiple age-related changes that may affect PS performance. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL19482 GPL27757

84 Samples

Download data: CSV

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

71 Samples

Download data: CEL

(Submitter supplied) Functional alterations in medial temporal lobe structures, particularly the hippocampus, are central to age-related deficits in episodic memory. Research in aging laboratory animals has characterized physiological and cellular alterations in the hippocampus that occur in association with the presence and severity of such cognitive impairment. The current study compares alterations across hippocampal subregions by gene expression profiling in a rat model that closely mirrors individual differences in neurocognitive features of aging humans across a spectrum of outcomes, including both impaired memory and preserved function. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

24 Samples

Download data: CEL

(Submitter supplied) Functional alterations in medial temporal lobe structures, particularly the hippocampus, are central to age-related deficits in episodic memory. Research in aging laboratory animals has characterized physiological and cellular alterations in the hippocampus that occur in association with the presence and severity of such cognitive impairment. The current study compares alterations across hippocampal subregions by gene expression profiling in a rat model that closely mirrors individual differences in neurocognitive features of aging humans across a spectrum of outcomes, including both impaired memory and preserved function. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

23 Samples

Download data: CEL

(Submitter supplied) Functional alterations in medial temporal lobe structures, particularly the hippocampus, are central to age-related deficits in episodic memory. Research in aging laboratory animals has characterized physiological and cellular alterations in the hippocampus that occur in association with the presence and severity of such cognitive impairment. The current study compares alterations across hippocampal subregions by gene expression profiling in a rat model that closely mirrors individual differences in neurocognitive features of aging humans across a spectrum of outcomes, including both impaired memory and preserved function. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

24 Samples

Download data: CEL

(Submitter supplied) Male Fischer 344 rats aged 4 months (young, n=10), 14 months (mid-aged, n=10), and 24 months (aged, n=10) were trained sequentially on two tasks: Morris Spatial Water Maze (SWM) and Object Memory Task (OMT). The training/testing sequence lasted 7 d, and hippocampal tissue was collected 24 hr later. Training and testing occured on each day except for days 2 and 3 of the 7 d sequence. (01/10/05: Series was updated to correct mislabeling of all sample signal values within the Young Treatment Group) Keywords = bioinformatics Keywords = gene expression Keywords = memory Keywords = synaptic plasticity Keywords = myelin Keywords = inflamation Keywords = aging Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS520

Platform:

GPL85

29 Samples

Download data: CEL, TXT

Identification of aging-dependent cognitive decline gene expression. Hippocampal CA1 tissue collected from 4, 14, and 24 month old male Fischer 344 rats after 7 days training on water maze and object memory task.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL85

Series:

GSE854

29 Samples

Download data: CEL, TXT

(Submitter supplied) Aging is often associated with cognitive decline, but many elderly individuals maintain a high level of function throughout life. Here we studied outbred rats, which also exhibit individual differences across a spectrum of outcomes that includes both preserved and impaired spatial memory. Previous work in this model identified the CA3 subfield of the hippocampus as a region critically affected by age and integral to differing cognitive outcomes. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

31 Samples

Download data: CEL

(Submitter supplied) The aim of this study was to investigate whether the differences in memory decline associated with aging are a result of differences in gene expression. We first categorized age-unimpaired and age-impaired rats based on their performance in the Morris water maze, when compared to young rats. Then we isolated messenger RNA from the dentate gyrus of the hippocampus of each animal to interrogate Affymetrix RAE 230A rat genome microarrays. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

79 Samples

Download data

(Submitter supplied) We report a bulk transcriptomic dataset of mouse dorsal hippocampus to identify gene expression changes of spatial object recognition training. We report a spatial transcriptomics dataset of mouse brain tissue generated with the 10x Genomics Visium platform to identify gene expression profiles of spatial object recognition training. We report a single nuclei ATAC-seq and a Single nuclei RNA-sequencing using SPLiT-pool barcoding datasets of mouse dorsal hippocampus to identify chromatin and gene expression changes of spatial object recognition training.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL24247

34 Samples

Download data: TAR, TXT

(Submitter supplied) We report a spatial transcriptomics dataset of mouse brain tissue generated with the 10x Genomics Visium platform to identify gene expression profiles of spatial object recognition training.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

6 Samples

Download data: TAR

(Submitter supplied) Recent microarray studies in the hippocampus of rodents or Alzheimer’s disease (AD) subjects have identified a substantial number of cellular pathways/processes correlated with aging and cognitive decline. However, the temporal relationships among these expression changes or with cognitive impairment have not been studied in depth. Here, using Affymetrix microarrays, immunohistochemistry and Morris water maze cognitive testing across 5 age groups of male F344 rats (n=9-15/group, one microarray per animal), we systematically analyzed the temporal sequence and cellular localization of aging changes in expression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3915

Platform:

GPL341

49 Samples

Download data: CEL

Analysis of hippocampi from F344 males, at 5 age points across the adult lifespan, tested on the Morris water maze (MWM) task. MWM is a dorsal hippocampal-dependent, spatial memory task. MWM performance showed an age effect. Results provide insight into the molecular basis of cognitive aging.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 age sets

Platform:

GPL341

Series:

GSE9990

49 Samples

Download data: CEL

(Submitter supplied) Aging is associated with a decline in hippocampal mediated learning and memory, a process wich can be ameliorated by dietary (caloric) restriction. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction. Old rats were determined to be good performers (GP) or poor performers (PP) in behavioral tests to assess thier hippocampal function.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

45 Samples

Download data: CEL, CHP, TXT, XLS

(Submitter supplied) Although immediate early genes (IEGs) such as Bdnf, Arc and Egr1, have been implicated in plasticity, the larger pathways related to memory and memory disorders are not well understood. Here, we combined statistical Affymetrix microarray and behavioral analyses to identify key genes and pathways associated with aging-related cognitive impairment. Aged rats were separated into cognitively unimpaired (AU) or impaired (AI) groups, based on their Morris water maze performance relative to young-adult (Y) animals. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2639

Platform:

GPL341

78 Samples

Download data: CEL, EXP, XLS

Analysis of hippocampi from aged learning-impaired animals on the last day of training in the Morris water maze (MWZ) or 21 days post-training. The MWZ task is a dorsal hippocampal-dependent task. Results provide insight into the molecular basis of aging-related cognitive impairment.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 age, 3 disease state, 3 protocol sets

Platform:

GPL341

Series:

GSE5666

78 Samples

Download data: CEL, EXP

(Submitter supplied) The aim of this study was to investigate whether the differences in memory decline associated with aging are a result of differences in gene expression. We first categorized age-unimpaired and age-impaired rats based on their performance in the Morris Water Maze and then isolated messenger RNA from the CA1 hippocampal region of each animal to interrogate Affymetrix microarrays. Microarray analysis (p<0.005) identified a set of 50 genes that were transcribed differently in age-unimpaired animals that had successfully learned a spatial task compared to aged learning-impaired animals and a variety of groups designed to control for all non-learning aspects of exposure to the water maze paradigm. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

79 Samples

Download data

(Submitter supplied) Vitamin D is an important calcium-regulating hormone with diverse functions in numerous tissues including the brain. Increasing evidence suggests that vitamin D may play a role in maintaining cognitive function and that vitamin D deficiency may accelerate age-related cognitive decline. Using aging rodents, we attempted to model the range of human serum vitamin D levels, from deficient to sufficient, to test whether vitamin D could preserve or improve cognitive function with aging. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS5345

Platform:

GPL6247

26 Samples

Download data: CEL

Analysis of hippocampus from F344 rats fed dietary supplement of cholecalciferol (vitamin D3) at doses of 10,000, 1000 and 100 IU/kg diet for 18 weeks. Results provide insight into molecular mechanisms underlying vitamin D-mediated synaptic function enhancement.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 dose sets

Platform:

GPL6247

Series:

GSE61326

26 Samples

Download data: CEL